| 1 | Mon Nov 6 | vs E Texas A&M | W78-46 | 1-0 | 1.000 | #15 | | Reed Arena · College Station, TX |
| 2 | Fri Nov 10 | at Ohio State | W73-66 | 2-0 | 1.000 | #15 | | Value City Arena · Columbus, OH |
| 3 | Tue Nov 14 | at SMU | W79-66 | 3-0 | 1.000 | #13 | | Moody Coliseum · Dallas, TX |
| 4 | Fri Nov 17 | vs Oral Roberts | W74-66 | 4-0 | 1.000 | #13 | | Reed Arena · College Station, TX |
| 5 | Thu Nov 23 | vs Penn State | W89-77 | 5-0 | 1.000 | #12 | ESPN | Reed Arena · College Station, TX |
| 6 | Fri Nov 24 | at #19FAU | L89-96 | 5-1 | .833 | #12 | ESPN2 | FAU Arena · Boca Raton, FL |
| 7 | Sun Nov 26 | at Iowa State | W73-69 | 6-1 | .857 | #12 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 8 | Wed Nov 29 | at Virginia | L47-59 | 6-2 | .750 | #14 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 9 | Wed Dec 6 | vs DePaul | W89-64 | 7-2 | .778 | #21 | SEC Network | Reed Arena · College Station, TX |
| 10 | Sun Dec 10 | vs Memphis | L75-81 | 7-3 | .700 | #21 | ESPN2 | Reed Arena · College Station, TX |
| 11 | Sat Dec 16 | at #4Houston | L66-70 | 7-4 | .636 | - | ESPN2 | Fertitta Center · Houston, TX |
| 12 | Fri Dec 22 | vs Hou Christian | W79-52 | 8-4 | .667 | - | SEC Network | Reed Arena · College Station, TX |
| 13 | Sat Dec 30 | vs Prairie View | W79-54 | 9-4 | .692 | - | SEC Network | Reed Arena · College Station, TX |
| 14 | Sat Jan 6 | vs LSU | L53-68 | 9-5 | .643 | - | SEC Network | Reed Arena · College Station, TX |
| 15 | Tue Jan 9 | at #16Auburn | L55-66 | 9-6 | .600 | - | ESPN2 | Neville Arena · Auburn, AL |
| 16 | Sat Jan 13 | vs #6Kentucky | W97-92 (OT) | 10-6 | .625 | - | ESPN | Reed Arena · College Station, TX |
| 17 | Tue Jan 16 | at Arkansas | L77-78 | 10-7 | .588 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 18 | Sat Jan 20 | atLSU | W73-69 | 11-7 | .611 | - | ESPNU | Pete Maravich Assembly Center · Baton Rouge, LA |
| 19 | Tue Jan 23 | vs Missouri | W63-57 | 12-7 | .632 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 27 | vs Ole Miss | L68-71 | 12-8 | .600 | - | SEC Network | Reed Arena · College Station, TX |
| 21 | Sat Feb 3 | vs Florida | W67-66 | 13-8 | .619 | - | ESPN2 | Reed Arena · College Station, TX |
| 22 | Wed Feb 7 | atMissouri | W79-60 | 14-8 | .636 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 10 | vs #6Tennessee | W85-69 | 15-8 | .652 | - | ESPN | Reed Arena · College Station, TX |
| 24 | Tue Feb 13 | at Vanderbilt | L73-74 | 15-9 | .625 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 17 | at #15Alabama | L75-100 | 15-10 | .600 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 26 | Tue Feb 20 | vsArkansas | L71-78 | 15-11 | .577 | - | ESPN | Reed Arena · College Station, TX |
| 27 | Sat Feb 24 | at#5Tennessee | L51-86 | 15-12 | .556 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 28 | Wed Feb 28 | vs #18South Carolina | L68-70 | 15-13 | .536 | - | SEC Network | Reed Arena · College Station, TX |
| 29 | Sat Mar 2 | at Georgia | W70-56 | 16-13 | .552 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 30 | Wed Mar 6 | vs Mississippi St | W75-69 | 17-13 | .567 | - | ESPNU | Reed Arena · College Station, TX |
| 31 | Sat Mar 9 | atOle Miss | W86-60 | 18-13 | .581 | - | CBS | SJB Pavilion · Oxford, MS |
| 32 | Thu Mar 14 | vsOle Miss | W80-71 | 19-13 | .594 | - | SEC Network | Reed Arena · College Station, TX |
| 33 | Fri Mar 15 | at#9Kentucky | W97-87 | 20-13 | .606 | - | SEC Network | Rupp Arena · Lexington, KY |
| 34 | Sat Mar 16 | atFlorida | L90-95 | 20-14 | .588 | - | ESPN | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 35 | Fri Mar 22 | at #8Nebraska | W98-83 | 21-14 | .600 | #9 | TNT | Pinnacle Bank Arena · Lincoln, NE |
| 36 | Sun Mar 24 | at#1Houston | L95-100 (OT) | 21-15 | .583 | #9 | TNT | Fertitta Center · Houston, TX |
