| 1 | Sat Nov 28 | at TCU | L65-70 | 0-1 | .000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Sun Nov 29 | vs South Carolina | L58-69 | 0-2 | .000 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 3 | Fri Dec 4 | vs UT Arlington | W79-64 | 1-2 | .333 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 5 | Sat Dec 12 | at Oral Roberts | PPD | 11-12 | .478 | - | | Mabee Center · Tulsa, OK |
| 6 | Tue Dec 15 | vs Wichita St | L65-69 | 1-3 | .250 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 7 | Fri Dec 18 | vs N'Western St | W82-55 | 2-3 | .400 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 8 | Mon Dec 21 | at Memphis | W56-49 | 3-3 | .500 | - | ESPN2 | FedExForum · Memphis, TN |
| 9 | Wed Dec 23 | vs TBD | W102-45 | 4-3 | .571 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 10 | Tue Dec 29 | vs #5Houston | W65-64 | 5-3 | .625 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 11 | Sat Jan 2 | at Cincinnati | W70-66 | 6-3 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Wed Jan 6 | at South Florida | W61-51 | 7-3 | .700 | - | | Yuengling Center · Tampa, FL |
| 13 | Sat Jan 9 | vs UCF | PPD | 11-12 | .478 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 14 | Wed Jan 13 | atWichita St | L53-72 | 7-4 | .636 | - | | Charles Koch Arena · Wichita, KS |
| 15 | Sun Jan 17 | vsMemphis | W58-57 | 8-4 | .667 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 16 | Wed Jan 20 | at#8Houston | L59-86 | 8-5 | .615 | - | | Fertitta Center · Houston, TX |
| 17 | Sat Jan 23 | vs Tulane | PPD | 11-12 | .478 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 18 | Tue Jan 26 | at Temple | L67-76 | 8-6 | .571 | - | | Liacouras Center · Philadelphia, PA |
| 19 | Sat Jan 30 | at E Carolina | W77-68 | 9-6 | .600 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 20 | Wed Feb 3 | vs SMU | L63-65 | 9-7 | .563 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Sat Feb 6 | vsUCF | L58-65 | 9-8 | .529 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Wed Feb 10 | vsTulane | L48-58 | 9-9 | .500 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Tue Feb 16 | vsTemple | W72-66 | 10-9 | .526 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 24 | Wed Feb 24 | vsCincinnati | L69-70 | 10-10 | .500 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Tue Mar 2 | atUCF | L69-73 | 10-11 | .476 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 27 | Thu Mar 4 | vsTBD | W107-74 | 11-11 | .500 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 29 | Thu Mar 11 | vsTulane | L70-77 | 11-12 | .478 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
