| 1 | Mon Nov 3 | vs TBD | W100-57 | 1-0 | 1.000 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 2 | Fri Nov 7 | atRhode Island | W82-65 | 2-0 | 1.000 | - | CBSSN | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Wed Nov 12 | atOral Roberts | W88-87 | 3-0 | 1.000 | - | | Mabee Center · Tulsa, OK |
| 4 | Mon Nov 17 | atKansas St | L83-84 | 3-1 | .750 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 5 | Fri Nov 21 | vsAustin Peay | W84-75 | 4-1 | .800 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 6 | Tue Nov 25 | atSan Jose St | W81-51 | 5-1 | .833 | - | CBSSN | Provident Credit Union Event Center · San Jose, CA |
| 7 | Wed Nov 26 | vsNorthern Iowa | W63-60 | 6-1 | .857 | - | CBSSN | Donald W. Reynolds Center · Tulsa, OK |
| 8 | Tue Dec 2 | vsTBD | W111-60 | 7-1 | .875 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 9 | Sat Dec 6 | vsMissouri St | W98-74 | 8-1 | .889 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 10 | Wed Dec 10 | vsAR-Pine Bluff | W117-84 | 9-1 | .900 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 11 | Sat Dec 13 | atNew Mexico St | W83-70 | 10-1 | .909 | - | | Pan American Center · Las Cruces, NM |
| 12 | Fri Dec 19 | atWestern KY | W82-81 | 11-1 | .917 | - | ESPN+ | E. A. Diddle Arena · Bowling Green, KY |
| 13 | Mon Dec 22 | vsDenver | W90-85 | 12-1 | .923 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 14 | Wed Dec 31 | vsRice | W97-48 | 13-1 | .929 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sun Jan 4 | atNorth Texas | L67-72 | 13-2 | .867 | - | ESPN+ | The Super Pit · Denton, TX |
| 16 | Sat Jan 10 | vsSouth Florida | L78-93 | 13-3 | .813 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 17 | Wed Jan 14 | atCharlotte | W86-74 | 14-3 | .824 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 18 | Sun Jan 18 | atUAB | W99-77 | 15-3 | .833 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 19 | Wed Jan 21 | vsMemphis | W83-66 | 16-3 | .842 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 20 | Sat Jan 24 | atRice | W87-81 | 17-3 | .850 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 21 | Wed Jan 28 | vsNorth Texas | W82-66 | 18-3 | .857 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Sun Feb 1 | vsWichita St | W93-83 | 19-3 | .864 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Wed Feb 4 | atFAU | W78-76 | 20-3 | .870 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 24 | Sun Feb 8 | atSouth Florida | L74-80 | 20-4 | .833 | - | ESPNU | Yuengling Center · Tampa, FL |
| 25 | Wed Feb 11 | vsUAB | L63-68 | 20-5 | .800 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Sat Feb 14 | atWichita St | L77-81 | 20-6 | .769 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 27 | Wed Feb 18 | vsCharlotte | W79-74 | 21-6 | .778 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 28 | Sun Feb 22 | vsUTSA | W100-74 | 22-6 | .786 | - | ESPNEWS | Donald W. Reynolds Center · Tulsa, OK |
| 29 | Wed Feb 25 | atTulane | W90-56 | 23-6 | .793 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
