| 1 | Tue Nov 5 | vs Hou Christian | W80-72 | 1-0 | 1.000 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 2 | Sat Nov 9 | atUT Arlington | L59-73 | 1-1 | .500 | - | | College Park Center · Arlington, TX |
| 3 | Tue Nov 12 | vsOral Roberts | W74-67 | 2-1 | .667 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 4 | Sat Nov 16 | vsAustin Peay | W72-65 | 3-1 | .750 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 5 | Wed Nov 20 | vsSE Louisiana | W73-66 | 4-1 | .800 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 6 | Wed Nov 27 | vsSC State | W78-47 | 5-1 | .833 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 7 | Sat Nov 30 | atVanderbilt | W67-58 | 6-1 | .857 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Wed Dec 4 | vsAR-Pine Bluff | W72-39 | 7-1 | .875 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 9 | Sat Dec 7 | vsArkansas St | L63-66 | 7-2 | .778 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 10 | Wed Dec 11 | vsBoise St | W69-56 | 8-2 | .800 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 11 | Sat Dec 14 | atArkansas | L79-98 | 8-3 | .727 | - | ESPNU | Bud Walton Arena · Fayetteville, AR |
| 12 | Sat Dec 21 | vsColorado St | L104-111 (3OT) | 8-4 | .667 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 13 | Sun Dec 29 | atKansas St | L67-69 | 8-5 | .615 | - | | Bramlage Coliseum · Manhattan, KS |
| 14 | Fri Jan 3 | vsTemple | W70-44 | 9-5 | .643 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Wed Jan 8 | atCincinnati | L44-75 | 9-6 | .600 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 16 | Sat Jan 11 | vsHouston | W63-61 | 10-6 | .625 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 17 | Wed Jan 15 | atE Carolina | W65-49 | 11-6 | .647 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 18 | Sat Jan 18 | atTulane | W67-54 | 12-6 | .667 | - | | Devlin Fieldhouse · New Orleans, LA |
| 19 | Wed Jan 22 | vs20Memphis | W80-40 | 13-6 | .684 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 20 | Sun Jan 26 | atUConn | W79-75 (OT) | 14-6 | .700 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 21 | Sat Feb 1 | vs23Wichita St | W54-51 | 15-6 | .714 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Thu Feb 6 | vsUConn | L56-72 | 15-7 | .682 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Sun Feb 9 | atUCF | L75-83 | 15-8 | .652 | - | | Addition Financial Arena · Orlando, FL |
| 24 | Wed Feb 12 | vsE Carolina | W70-56 | 16-8 | .667 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 25 | Sat Feb 15 | atSouth Florida | W56-48 | 17-8 | .680 | - | ESPNU | Yuengling Center · Tampa, FL |
| 26 | Wed Feb 19 | at22Houston | L43-76 | 17-9 | .654 | - | ESPNU | Fertitta Center · Houston, TX |
| 27 | Sat Feb 22 | vsSMU | W79-57 | 18-9 | .667 | - | ESPNEWS | Donald W. Reynolds Center · Tulsa, OK |
| 28 | Tue Feb 25 | vsTulane | W62-57 | 19-9 | .679 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 29 | Sat Feb 29 | vsUCF | W65-54 | 20-9 | .690 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 30 | Wed Mar 4 | atTemple | W61-51 | 21-9 | .700 | - | | Liacouras Center · Philadelphia, PA |
| 31 | Sun Mar 8 | atWichita St | L57-79 | 21-10 | .677 | - | CBSSN | Charles Koch Arena · Wichita, KS |
