| 1 | Mon Nov 7 | at Oregon St | L70-73 | 0-1 | .000 | - | | Gill Coliseum · Corvallis, OR |
| 2 | Sat Nov 12 | vsJackson St | W85-79 | 1-1 | .500 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 3 | Thu Nov 17 | vsLoyola Chicago | W85-66 | 2-1 | .667 | - | ESPNU | The HTC Center · Conway, SC |
| 4 | Fri Nov 18 | vsCharlotte | L65-68 | 2-2 | .500 | - | ESPNU | The HTC Center · Conway, SC |
| 5 | Sun Nov 20 | vsMurray St | L60-77 | 2-3 | .400 | - | ESPNU | The HTC Center · Conway, SC |
| 6 | Fri Nov 25 | atOklahoma St | L56-82 | 2-4 | .333 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Sat Dec 3 | vsOral Roberts | L66-77 | 2-5 | .286 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 8 | Wed Dec 7 | vsDetroit Mercy | L72-76 | 2-6 | .250 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 9 | Sat Dec 10 | vsC Michigan | W70-63 | 3-6 | .333 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 10 | Fri Dec 16 | vsMiss Valley St | W66-51 | 4-6 | .400 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 11 | Wed Dec 21 | atLMU | L64-76 | 4-7 | .364 | - | | Gersten Pavilion · Los Angeles, CA |
| 12 | Wed Dec 28 | vs3Houston | L50-89 | 4-8 | .333 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 13 | Sun Jan 1 | atSMU | L67-92 | 4-9 | .308 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 14 | Wed Jan 4 | atTulane | L77-93 | 4-10 | .286 | - | | Devlin Fieldhouse · New Orleans, LA |
| 15 | Tue Jan 10 | vsTemple | L72-76 | 4-11 | .267 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 16 | Sat Jan 14 | atWichita St | L69-73 | 4-12 | .250 | - | | Charles Koch Arena · Wichita, KS |
| 17 | Wed Jan 18 | vsSMU | L76-79 (OT) | 4-13 | .235 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 18 | Sat Jan 21 | vsTulane | W81-79 (OT) | 5-13 | .278 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 19 | Tue Jan 24 | atE Carolina | L66-76 | 5-14 | .263 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 20 | Sun Jan 29 | vsMemphis | L68-80 | 5-15 | .250 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Wed Feb 1 | atCincinnati | L55-81 | 5-16 | .238 | - | | Fifth Third Arena · Cincinnati, OH |
| 22 | Sun Feb 5 | vsWichita St | L75-86 | 5-17 | .227 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Wed Feb 8 | at2Houston | L42-80 | 5-18 | .217 | - | | Fertitta Center · Houston, TX |
| 24 | Sat Feb 11 | atUCF | L52-96 | 5-19 | .208 | - | | Addition Financial Arena · Orlando, FL |
| 25 | Wed Feb 15 | vsSouth Florida | L69-96 | 5-20 | .200 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Sun Feb 19 | atTemple | L53-76 | 5-21 | .192 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 27 | Tue Feb 21 | vsE Carolina | L60-62 | 5-22 | .185 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 28 | Sun Feb 26 | vsUCF | L49-68 | 5-23 | .179 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 29 | Wed Mar 1 | atSouth Florida | L56-72 | 5-24 | .172 | - | | Yuengling Center · Tampa, FL |
| 30 | Thu Mar 9 | atWichita St | L63-81 | 5-25 | .167 | - | ESPNU | Charles Koch Arena · Wichita, KS |
