| 1 | Wed Nov 6 | vs Long Beach St | W69-65 | 1-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 2 | Sun Nov 10 | vsUCSB | W77-61 | 2-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 3 | Fri Nov 15 | vsUNLV | W71-54 | 3-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 4 | Mon Nov 18 | vsSouthern Utah | W76-61 | 4-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 5 | Thu Nov 21 | vsHofstra | L78-88 | 4-1 | .800 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 6 | Mon Nov 25 | vsBYU | L63-78 | 4-2 | .667 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 7 | Tue Nov 26 | atTBD | W74-48 | 5-2 | .714 | - | ESPNU | Lahaina Civic Center |
| 8 | Wed Nov 27 | vsMichigan St | L62-75 | 5-3 | .625 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 9 | Sun Dec 1 | vsSan Jose St | W93-64 | 6-3 | .667 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 10 | Sun Dec 8 | vsDenver | W81-62 | 7-3 | .700 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 11 | Sat Dec 14 | atNotre Dame | L61-75 | 7-4 | .636 | - | ABC | Purcell Pavilion · South Bend, IN |
| 12 | Sat Dec 21 | atUNC | L64-74 | 7-5 | .583 | - | CBS | T-Mobile Arena · Las Vegas, NV |
| 13 | Sat Dec 28 | vsFullerton | L74-77 | 7-6 | .538 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 14 | Thu Jan 2 | atWashington | W66-64 | 8-6 | .571 | - | | Alaska Airlines Arena · Seattle, WA |
| 15 | Sat Jan 4 | atWashington St | L71-79 (OT) | 8-7 | .533 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 16 | Sat Jan 11 | vsUSC | L63-74 | 8-8 | .500 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 17 | Wed Jan 15 | vsStanford | L59-74 | 8-9 | .471 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 18 | Sun Jan 19 | vsCalifornia | W50-40 | 9-9 | .500 | - | ESPNU | Pauley Pavilion · Los Angeles, CA |
| 19 | Thu Jan 23 | atOregon St | W62-58 | 10-9 | .526 | - | FS1 | Gill Coliseum · Corvallis, OR |
| 20 | Sun Jan 26 | at12Oregon | L75-96 | 10-10 | .500 | - | | Matthew Knight Arena · Eugene, OR |
| 21 | Thu Jan 30 | vs20Colorado | W72-68 | 11-10 | .524 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 22 | Sun Feb 2 | vsUtah | W73-57 | 12-10 | .545 | - | | Pauley Pavilion · Los Angeles, CA |
| 23 | Thu Feb 6 | atArizona St | L66-84 | 12-11 | .522 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 24 | Sat Feb 8 | at23Arizona | W65-52 | 13-11 | .542 | - | ESPN2 | McKale Center · Tucson, AZ |
| 25 | Thu Feb 13 | vsWashington St | W86-83 (OT) | 14-11 | .560 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 26 | Sat Feb 15 | vsWashington | W67-57 | 15-11 | .577 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 27 | Thu Feb 20 | atUtah | W69-58 | 16-11 | .593 | - | | Jon M. Huntsman Center · Salt Lake City, UT |
| 28 | Sat Feb 22 | at18Colorado | W70-63 | 17-11 | .607 | - | CBS | CU Events Center · Boulder, CO |
| 29 | Thu Feb 27 | vsArizona St | W75-72 | 18-11 | .621 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 30 | Sat Feb 29 | vsArizona | W69-64 | 19-11 | .633 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 31 | Sat Mar 7 | atUSC | L52-54 | 19-12 | .613 | - | CBS | Galen Center · Los Angeles, CA |
