| 1 | Mon Nov 3 | vs E Washington | W80-74 | 1-0 | 1.000 | #12 | BTN | Pauley Pavilion · Los Angeles, CA |
| 2 | Fri Nov 7 | vsPepperdine | W74-63 | 2-0 | 1.000 | #12 | BTN | Pauley Pavilion · Los Angeles, CA |
| 3 | Mon Nov 10 | vsW Georgia | W83-62 | 3-0 | 1.000 | #15 | B1G+ | Pauley Pavilion · Los Angeles, CA |
| 4 | Fri Nov 14 | vs5Arizona | L65-69 | 3-1 | .750 | #15 | Peacock | Intuit Dome · Inglewood, CA |
| 5 | Tue Nov 18 | vsSacramento St | W79-48 | 4-1 | .800 | #19 | BTN | Pauley Pavilion · Los Angeles, CA |
| 6 | Fri Nov 21 | vsPresbyterian | W86-46 | 5-1 | .833 | #19 | BTN | Pauley Pavilion · Los Angeles, CA |
| 7 | Tue Nov 25 | atCalifornia | L72-80 | 5-2 | .714 | #18 | ESPN | Chase Center · San Francisco, CA |
| 8 | Wed Dec 3 | atWashington | W82-80 | 6-2 | .750 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 9 | Sat Dec 6 | vsOregon | W74-63 | 7-2 | .778 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 10 | Sat Dec 13 | at8Gonzaga | L72-82 | 7-3 | .700 | #25 | ESPN | McCarthey Athletic Center · Spokane, WA |
| 11 | Wed Dec 17 | vsArizona St | W90-77 | 8-3 | .727 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 12 | Fri Dec 19 | vsCal Poly | W108-87 | 9-3 | .750 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 13 | Tue Dec 23 | vsUC Riverside | W97-65 | 10-3 | .769 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 14 | Sat Jan 3 | at25Iowa | L61-74 | 10-4 | .714 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 15 | Tue Jan 6 | atWisconsin | L72-80 | 10-5 | .667 | - | Peacock | Kohl Center · Madison, WI |
| 16 | Sat Jan 10 | vsMaryland | W67-55 | 11-5 | .688 | - | FOX | Pauley Pavilion · Los Angeles, CA |
| 17 | Wed Jan 14 | atPenn State | W71-60 | 12-5 | .706 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 18 | Sat Jan 17 | atOhio State | L74-86 | 12-6 | .667 | - | CBS | Value City Arena · Columbus, OH |
| 19 | Tue Jan 20 | vs4Purdue | W69-67 | 13-6 | .684 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 20 | Sat Jan 24 | vsNorthwestern | W71-64 | 14-6 | .700 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 21 | Wed Jan 28 | atOregon | W73-57 | 15-6 | .714 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 22 | Sat Jan 31 | vsIndiana | L97-98 (2OT) | 15-7 | .682 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 23 | Tue Feb 3 | vsRutgers | W98-66 | 16-7 | .696 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 24 | Sat Feb 7 | vsWashington | W77-73 | 17-7 | .708 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 25 | Sat Feb 14 | at2Michigan | L56-86 | 17-8 | .680 | - | CBS | Crisler Center · Ann Arbor, MI |
| 26 | Tue Feb 17 | at15Michigan St | L59-82 | 17-9 | .654 | - | Peacock | Breslin Center · East Lansing, MI |
| 27 | Sat Feb 21 | vs10Illinois | W95-94 (OT) | 18-9 | .667 | - | FOX | Pauley Pavilion · Los Angeles, CA |
| 28 | Tue Feb 24 | vsUSC | W81-62 | 19-9 | .679 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 29 | Sat Feb 28 | atMinnesota | L73-78 | 19-10 | .655 | - | FS1 | Williams Arena · Minneapolis, MN |
