| 1 | Mon Nov 7 | vs Sacramento St | W76-50 | 1-0 | 1.000 | #8 | PACN | Pauley Pavilion · Los Angeles, CA |
| 2 | Fri Nov 11 | vs Long Beach St | W93-69 | 2-0 | 1.000 | #8 | PACN | Pauley Pavilion · Los Angeles, CA |
| 3 | Mon Nov 14 | vs Norfolk St | W86-56 | 3-0 | 1.000 | #8 | PACN | Pauley Pavilion · Los Angeles, CA |
| 4 | Fri Nov 18 | vs Illinois | L70-79 | 3-1 | .750 | - | ESPNU | Pauley Pavilion · Los Angeles, CA |
| 5 | Sun Nov 20 | at Baylor | L75-80 | 3-2 | .600 | - | ESPN | Ferrell Center · Waco, TX |
| 6 | Wed Nov 23 | vs Pepperdine | W100-53 | 4-2 | .667 | #19 | PACN | Pauley Pavilion · Los Angeles, CA |
| 7 | Sun Nov 27 | vs Bellarmine | W81-60 | 5-2 | .714 | #19 | PACN | Pauley Pavilion · Los Angeles, CA |
| 8 | Thu Dec 1 | at Stanford | W80-66 | 6-2 | .750 | #21 | ESPN2 | Maples Pavilion · Stanford, CA |
| 9 | Sun Dec 4 | vs Oregon | W65-56 | 7-2 | .778 | #21 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 10 | Sat Dec 10 | vs Denver | W87-64 | 8-2 | .800 | #19 | PACN | Pauley Pavilion · Los Angeles, CA |
| 11 | Wed Dec 14 | at #20Maryland | W87-60 | 9-2 | .818 | #16 | FS1 | XFINITY Center · College Park, MD |
| 12 | Sat Dec 17 | at Kentucky | W63-53 | 10-2 | .833 | - | CBS | Rupp Arena · Lexington, KY |
| 13 | Wed Dec 21 | vs UC Davis | W81-54 | 11-2 | .846 | #13 | PACN | Pauley Pavilion · Los Angeles, CA |
| 14 | Fri Dec 30 | at Washington St | W67-66 | 12-2 | .857 | #11 | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 15 | Sun Jan 1 | at Washington | W74-49 | 13-2 | .867 | #11 | PACN | Alaska Airlines Arena · Seattle, WA |
| 16 | Thu Jan 5 | vs USC | W60-58 | 14-2 | .875 | #10 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 17 | Thu Jan 12 | vs Utah | W68-49 | 15-2 | .882 | #7 | PACN | Pauley Pavilion · Los Angeles, CA |
| 18 | Sat Jan 14 | vs Colorado | W68-54 | 16-2 | .889 | #7 | FOX | Pauley Pavilion · Los Angeles, CA |
| 19 | Thu Jan 19 | at Arizona St | W74-62 | 17-2 | .895 | #5 | FS1 | Desert Financial Arena · Tempe, AZ |
| 20 | Sat Jan 21 | at #11Arizona | L52-58 | 17-3 | .850 | #5 | ABC | McKale Center · Tucson, AZ |
| 21 | Thu Jan 26 | atUSC | L64-77 | 17-4 | .810 | #8 | ESPN2 | Galen Center · Los Angeles, CA |
| 22 | Thu Feb 2 | vsWashington | W70-61 | 18-4 | .818 | #9 | FS1 | Pauley Pavilion · Los Angeles, CA |
| 23 | Sat Feb 4 | vsWashington St | W76-52 | 19-4 | .826 | #9 | PACN | Pauley Pavilion · Los Angeles, CA |
| 24 | Thu Feb 9 | at Oregon St | W62-47 | 20-4 | .833 | #7 | PACN | Gill Coliseum · Corvallis, OR |
| 25 | Sat Feb 11 | atOregon | W70-63 | 21-4 | .840 | #7 | ESPN | Matthew Knight Arena · Eugene, OR |
| 26 | Thu Feb 16 | vsStanford | W73-64 | 22-4 | .846 | #4 | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 27 | Sat Feb 18 | vs California | W78-43 | 23-4 | .852 | #4 | PACN | Pauley Pavilion · Los Angeles, CA |
| 28 | Thu Feb 23 | atUtah | W78-71 | 24-4 | .857 | #4 | FS1 | Jon M. Huntsman Center · Salt Lake City, UT |
| 29 | Sun Feb 26 | atColorado | W60-56 | 25-4 | .862 | #4 | CBS | CU Events Center · Boulder, CO |
| 30 | Thu Mar 2 | vsArizona St | W79-61 | 26-4 | .867 | #4 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 31 | Sat Mar 4 | vs#8Arizona | W82-73 | 27-4 | .871 | #4 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 32 | Thu Mar 9 | vsColorado | W80-69 | 28-4 | .875 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 33 | Fri Mar 10 | vsOregon | W75-56 | 29-4 | .879 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 34 | Sat Mar 11 | vsArizona | L59-61 | 29-5 | .853 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 35 | Thu Mar 16 | vs #15UNC Asheville | W86-53 | 30-5 | .857 | #2 | truTV | Pauley Pavilion · Los Angeles, CA |
| 36 | Sat Mar 18 | vs #7Northwestern | W68-63 | 31-5 | .861 | #2 | TNT | Pauley Pavilion · Los Angeles, CA |
| 37 | Thu Mar 23 | vs #3Gonzaga | L76-79 | 31-6 | .838 | #2 | CBS | Pauley Pavilion · Los Angeles, CA |
