| 1 | Mon Nov 4 | vs Rider | W85-50 | 1-0 | 1.000 | #22 | FS1 | Pauley Pavilion · Los Angeles, CA |
| 2 | Fri Nov 8 | vsNew Mexico | L64-72 | 1-1 | .500 | #22 | CBS | Pauley Pavilion · Los Angeles, CA |
| 3 | Mon Nov 11 | vsBoston Univ | W71-40 | 2-1 | .667 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 4 | Fri Nov 15 | vsLehigh | W85-45 | 3-1 | .750 | - | B1G+ | Pauley Pavilion · Los Angeles, CA |
| 5 | Wed Nov 20 | vsIdaho St | W84-70 | 4-1 | .800 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 6 | Fri Nov 22 | vsFullerton | W80-47 | 5-1 | .833 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 7 | Tue Nov 26 | vsSouthern Utah | W88-43 | 6-1 | .857 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 8 | Tue Dec 3 | vsWashington | W69-58 | 7-1 | .875 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 9 | Sun Dec 8 | at#12Oregon | W73-71 | 8-1 | .889 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 10 | Sat Dec 14 | atArizona | W57-54 | 9-1 | .900 | #24 | ESPN2 | McKale Center · Tucson, AZ |
| 11 | Tue Dec 17 | vsPrairie View | W111-75 | 10-1 | .909 | #18 | BTN | Pauley Pavilion · Los Angeles, CA |
| 12 | Sat Dec 21 | vsUNC | L74-76 | 10-2 | .833 | #18 | CBS | Pauley Pavilion · Los Angeles, CA |
| 13 | Sat Dec 28 | vs#14Gonzaga | W65-62 | 11-2 | .846 | #22 | FOX | Pauley Pavilion · Los Angeles, CA |
| 14 | Sat Jan 4 | atNebraska | L58-66 | 11-3 | .786 | #15 | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Tue Jan 7 | vs#24Michigan | L75-94 | 11-4 | .733 | #22 | Peacock | Pauley Pavilion · Los Angeles, CA |
| 16 | Fri Jan 10 | atMaryland | L61-79 | 11-5 | .688 | #22 | FOX | XFINITY Center · College Park, MD |
| 17 | Mon Jan 13 | atRutgers | L68-75 | 11-6 | .647 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 18 | Fri Jan 17 | vsIowa | W94-70 | 12-6 | .667 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 19 | Tue Jan 21 | vs#18Wisconsin | W85-83 | 13-6 | .684 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 20 | Fri Jan 24 | atWashington | W65-60 | 14-6 | .700 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 21 | Mon Jan 27 | atUSC | W82-76 | 15-6 | .714 | - | FS1 | Galen Center · Los Angeles, CA |
| 22 | Thu Jan 30 | vs#16Oregon | W78-52 | 16-6 | .727 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 23 | Tue Feb 4 | vs#9Michigan St | W63-61 | 17-6 | .739 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 24 | Sat Feb 8 | vsPenn State | W78-54 | 18-6 | .750 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 25 | Tue Feb 11 | atIllinois | L78-83 | 18-7 | .720 | - | Peacock | State Farm Center · Champaign, IL |
| 26 | Fri Feb 14 | atIndiana | W72-68 | 19-7 | .731 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Tue Feb 18 | vsMinnesota | L61-64 | 19-8 | .704 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 28 | Sun Feb 23 | vsOhio State | W69-61 | 20-8 | .714 | - | CBS | Pauley Pavilion · Los Angeles, CA |
| 29 | Fri Feb 28 | at#20Purdue | L66-76 | 20-9 | .690 | - | FOX | Mackey Arena · West Lafayette, IN |
| 30 | Mon Mar 3 | atNorthwestern | W73-69 | 21-9 | .700 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sat Mar 8 | vsUSC | W90-63 | 22-9 | .710 | - | FOX | Pauley Pavilion · Los Angeles, CA |
| 32 | Fri Mar 14 | vs#18Wisconsin | L70-86 | 22-10 | .688 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 33 | Thu Mar 20 | vs#10Utah State | W72-47 | 23-10 | .697 | #7 | TNT | Rupp Arena · Lexington, KY |
| 34 | Sat Mar 22 | at#2Tennessee | L58-67 | 23-11 | .676 | #7 | TBS | Rupp Arena · Lexington, KY |
