| 1 | Mon Nov 6 | vs St Francis PA | W75-44 | 1-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 2 | Fri Nov 10 | vs Lafayette | W68-50 | 2-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 3 | Wed Nov 15 | vs Long Island | W78-58 | 3-0 | 1.000 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 4 | Mon Nov 20 | at #4Marquette | L69-71 | 3-1 | .750 | - | ESPN2 | Fiserv Forum · Milwaukee, WI |
| 5 | Tue Nov 21 | at TBD | W76-48 | 4-1 | .800 | - | ESPN2 | Stan Sheriff Center |
| 6 | Wed Nov 22 | vs #11Gonzaga | L65-69 | 4-2 | .667 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 7 | Thu Nov 30 | vs UC Riverside | W66-65 | 5-2 | .714 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 8 | Sat Dec 9 | at Villanova | L56-65 | 5-3 | .625 | - | FOX | Finneran Pavilion · Villanova, PA |
| 9 | Sat Dec 16 | at Ohio State | L60-67 | 5-4 | .556 | - | CBS | Value City Arena · Columbus, OH |
| 10 | Tue Dec 19 | vs CSU Northridge | L72-76 | 5-5 | .500 | - | | Pauley Pavilion · Los Angeles, CA |
| 11 | Fri Dec 22 | vs Maryland | L60-69 | 5-6 | .455 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 12 | Thu Dec 28 | at Oregon St | W69-62 | 6-6 | .500 | - | PACN | Gill Coliseum · Corvallis, OR |
| 13 | Sat Dec 30 | at Oregon | L59-64 | 6-7 | .462 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 14 | Wed Jan 3 | vs Stanford | L53-59 | 6-8 | .429 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 15 | Sat Jan 6 | vs California | L57-66 | 6-9 | .400 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 16 | Thu Jan 11 | at Utah | L44-90 | 6-10 | .375 | - | ESPN2 | Jon M. Huntsman Center · Salt Lake City, UT |
| 17 | Sun Jan 14 | vs Washington | W73-61 | 7-10 | .412 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 18 | Wed Jan 17 | at Arizona St | W68-66 | 8-10 | .444 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 19 | Sat Jan 20 | at #12Arizona | L71-77 | 8-11 | .421 | - | ESPN2 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 27 | at USC | W65-50 | 9-11 | .450 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 21 | Thu Feb 1 | vsOregon St | W71-63 | 10-11 | .476 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 22 | Sat Feb 3 | vsOregon | W71-63 | 11-11 | .500 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 23 | Wed Feb 7 | atStanford | W82-74 | 12-11 | .522 | - | PACN | Maples Pavilion · Stanford, CA |
| 24 | Sat Feb 10 | atCalifornia | W61-60 | 13-11 | .542 | - | FOX | Haas Pavilion · Berkeley, CA |
| 25 | Thu Feb 15 | vs Colorado | W64-60 | 14-11 | .560 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 26 | Sun Feb 18 | vsUtah | L69-70 | 14-12 | .538 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 27 | Sat Feb 24 | vsUSC | L56-62 | 14-13 | .519 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 28 | Thu Feb 29 | atWashington | L77-94 | 14-14 | .500 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 29 | Sat Mar 2 | at #19Washington St | L65-77 | 14-15 | .483 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 30 | Thu Mar 7 | vs#5Arizona | L65-88 | 14-16 | .467 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 31 | Sat Mar 9 | vsArizona St | W59-47 | 15-16 | .484 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 32 | Wed Mar 13 | vsOregon St | W67-57 | 16-16 | .500 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 33 | Thu Mar 14 | atOregon | L66-68 | 16-17 | .485 | - | PACN | Matthew Knight Arena · Eugene, OR |
