| 1 | Tue Nov 5 | vs FAMU | W77-48 | 1-0 | 1.000 | - | PACN | Galen Center · Los Angeles, CA |
| 2 | Fri Nov 8 | vsPortland | W76-65 | 2-0 | 1.000 | - | PACN | Galen Center · Los Angeles, CA |
| 3 | Tue Nov 12 | vsS Dakota St | W84-66 | 3-0 | 1.000 | - | | Galen Center · Los Angeles, CA |
| 4 | Sat Nov 16 | atNevada | W76-66 | 4-0 | 1.000 | - | CBSSN | Barclays Center · Brooklyn, NY |
| 5 | Tue Nov 19 | vsPepperdine | W91-84 | 5-0 | 1.000 | - | PACN | Galen Center · Los Angeles, CA |
| 6 | Fri Nov 22 | vsTemple | L61-70 | 5-1 | .833 | - | | Galen Center · Los Angeles, CA |
| 7 | Thu Nov 28 | atFairfield | W54-47 | 6-1 | .857 | - | ESPNU | Leo D. Mahoney Arena · Fairfield, CT |
| 8 | Fri Nov 29 | atMarquette | L79-101 | 6-2 | .750 | - | ESPN2 | Fiserv Forum · Milwaukee, WI |
| 9 | Sun Dec 1 | vsHarvard | W77-62 | 7-2 | .778 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 10 | Fri Dec 6 | atTCU | W80-78 | 8-2 | .800 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 11 | Sun Dec 15 | vsLong Beach St | W87-76 | 9-2 | .818 | - | PACN | Galen Center · Los Angeles, CA |
| 12 | Sat Dec 21 | vsLSU | W70-68 | 10-2 | .833 | - | FS1 | Galen Center · Los Angeles, CA |
| 13 | Sun Dec 29 | vsFGCU | W71-58 | 11-2 | .846 | - | PACN | Galen Center · Los Angeles, CA |
| 14 | Thu Jan 2 | atWashington St | W65-56 | 12-2 | .857 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 15 | Sun Jan 5 | atWashington | L40-72 | 12-3 | .800 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 16 | Sat Jan 11 | atUCLA | W74-63 | 13-3 | .813 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 17 | Thu Jan 16 | vsCalifornia | W88-56 | 14-3 | .824 | - | PACN | Galen Center · Los Angeles, CA |
| 18 | Sat Jan 18 | vsStanford | W82-78 (OT) | 15-3 | .833 | - | PACN | Galen Center · Los Angeles, CA |
| 19 | Thu Jan 23 | at12Oregon | L70-79 (2OT) | 15-4 | .789 | - | ESPNU | Matthew Knight Arena · Eugene, OR |
| 20 | Sat Jan 25 | atOregon St | W75-55 | 16-4 | .800 | - | PACN | Gill Coliseum · Corvallis, OR |
| 21 | Thu Jan 30 | vsUtah | W56-52 | 17-4 | .810 | - | | Galen Center · Los Angeles, CA |
| 22 | Sat Feb 1 | vs20Colorado | L57-78 | 17-5 | .773 | - | FS1 | Galen Center · Los Angeles, CA |
| 23 | Thu Feb 6 | at23Arizona | L80-85 | 17-6 | .739 | - | ESPN2 | McKale Center · Tucson, AZ |
| 24 | Sat Feb 8 | atArizona St | L64-66 | 17-7 | .708 | - | | Desert Financial Arena · Tempe, AZ |
| 25 | Thu Feb 13 | vsWashington | W62-56 | 18-7 | .720 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 26 | Sat Feb 15 | vsWashington St | W70-51 | 19-7 | .731 | - | PACN | Galen Center · Los Angeles, CA |
| 27 | Thu Feb 20 | at18Colorado | L66-70 | 19-8 | .704 | - | ESPN2 | CU Events Center · Boulder, CO |
| 28 | Sun Feb 23 | atUtah | L65-79 | 19-9 | .679 | - | ESPNU | Jon M. Huntsman Center · Salt Lake City, UT |
| 29 | Thu Feb 27 | vsArizona | W57-48 | 20-9 | .690 | - | ESPN | Galen Center · Los Angeles, CA |
| 30 | Sat Feb 29 | vsArizona St | W71-61 | 21-9 | .700 | - | ESPNU | Galen Center · Los Angeles, CA |
| 31 | Sat Mar 7 | vsUCLA | W54-52 | 22-9 | .710 | - | CBS | Galen Center · Los Angeles, CA |
