| 1 | Mon Nov 3 | vs Cal Poly | W94-64 | 1-0 | 1.000 | - | B1G+ | Galen Center · Los Angeles, CA |
| 2 | Sun Nov 9 | vsManhattan | W114-83 | 2-0 | 1.000 | - | B1G+ | Galen Center · Los Angeles, CA |
| 3 | Fri Nov 14 | vsIllinois St | W87-67 | 3-0 | 1.000 | - | Peacock | Intuit Dome · Inglewood, CA |
| 4 | Thu Nov 20 | vsTroy | W107-106 (3OT) | 4-0 | 1.000 | - | BTN | Galen Center · Los Angeles, CA |
| 5 | Mon Nov 24 | atBoise St | W70-67 | 5-0 | 1.000 | - | ESPN2 | ExtraMile Arena · Boise, ID |
| 6 | Tue Nov 25 | vsSeton Hall | W83-81 | 6-0 | 1.000 | - | ESPN | Galen Center · Los Angeles, CA |
| 7 | Wed Nov 26 | atArizona St | W88-75 | 7-0 | 1.000 | - | ESPN | Desert Financial Arena · Tempe, AZ |
| 8 | Tue Dec 2 | atOregon | W82-77 | 8-0 | 1.000 | #24 | FS1 | Matthew Knight Arena · Eugene, OR |
| 9 | Sat Dec 6 | vsWashington | L76-84 | 8-1 | .889 | #24 | BTN | Galen Center · Los Angeles, CA |
| 10 | Tue Dec 9 | atSan Diego | W94-81 | 9-1 | .900 | - | ESPN2 | Jenny Craig Pavilion · San Diego, CA |
| 11 | Sun Dec 14 | vsWashington St | W68-61 | 10-1 | .909 | - | FS1 | Galen Center · Los Angeles, CA |
| 12 | Wed Dec 17 | vsUTSA | W97-70 | 11-1 | .917 | - | BTN | Galen Center · Los Angeles, CA |
| 13 | Sun Dec 21 | vsTBD | W102-63 | 12-1 | .923 | - | | Galen Center · Los Angeles, CA |
| 14 | Fri Jan 2 | at2Michigan | L66-96 | 12-2 | .857 | #24 | Peacock | Crisler Center · Ann Arbor, MI |
| 15 | Mon Jan 5 | at12Michigan St | L51-80 | 12-3 | .800 | - | FS1 | Breslin Center · East Lansing, MI |
| 16 | Fri Jan 9 | atMinnesota | W70-69 (OT) | 13-3 | .813 | - | BTN | Williams Arena · Minneapolis, MN |
| 17 | Tue Jan 13 | vsMaryland | W88-71 | 14-3 | .824 | - | FS1 | Galen Center · Los Angeles, CA |
| 18 | Sat Jan 17 | vs5Purdue | L64-69 | 14-4 | .778 | - | Peacock | Galen Center · Los Angeles, CA |
| 19 | Wed Jan 21 | vsNorthwestern | L68-74 | 14-5 | .737 | - | BTN | Galen Center · Los Angeles, CA |
| 20 | Sun Jan 25 | atWisconsin | W73-71 | 15-5 | .750 | - | Peacock | Kohl Center · Madison, WI |
| 21 | Wed Jan 28 | atIowa | L72-73 | 15-6 | .714 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 22 | Sat Jan 31 | vsRutgers | W78-75 | 16-6 | .727 | - | Peacock | Galen Center · Los Angeles, CA |
| 23 | Tue Feb 3 | vsIndiana | W81-75 | 17-6 | .739 | - | Peacock | Galen Center · Los Angeles, CA |
| 24 | Sun Feb 8 | atPenn State | W77-75 | 18-6 | .750 | - | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Wed Feb 11 | atOhio State | L82-89 | 18-7 | .720 | - | BTN | Value City Arena · Columbus, OH |
| 26 | Wed Feb 18 | vs10Illinois | L65-101 | 18-8 | .692 | - | BTN | Galen Center · Los Angeles, CA |
| 27 | Sat Feb 21 | vsOregon | L70-71 | 18-9 | .667 | - | FS1 | Galen Center · Los Angeles, CA |
| 28 | Tue Feb 24 | atUCLA | L62-81 | 18-10 | .643 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 29 | Sat Feb 28 | vs12Nebraska | L67-82 | 18-11 | .621 | - | BTN | Galen Center · Los Angeles, CA |
