| 1 | Tue Nov 9 | vs CSU Northridge | W89-49 | 1-0 | 1.000 | - | PACN | Galen Center · Los Angeles, CA |
| 2 | Sat Nov 13 | atTemple | W76-71 | 2-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 3 | Tue Nov 16 | atFGCU | W78-61 | 3-0 | 1.000 | - | ESPNU | Alico Arena · Fort Myers, FL |
| 4 | Mon Nov 22 | vsUtah Tech | W98-71 | 4-0 | 1.000 | #24 | PACN | Galen Center · Los Angeles, CA |
| 5 | Thu Nov 25 | atSaint Joseph's | W70-55 | 5-0 | 1.000 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 6 | Fri Nov 26 | atSDSU | W58-43 | 6-0 | 1.000 | - | ESPN2 | Viejas Arena · San Diego, CA |
| 7 | Wed Dec 1 | vsUtah | W93-73 | 7-0 | 1.000 | #20 | PACN | Galen Center · Los Angeles, CA |
| 8 | Sat Dec 4 | atWashington St | W63-61 | 8-0 | 1.000 | #20 | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 9 | Tue Dec 7 | vsE Kentucky | W80-68 | 9-0 | 1.000 | #16 | PACN | Galen Center · Los Angeles, CA |
| 10 | Sun Dec 12 | vsLong Beach St | W73-62 | 10-0 | 1.000 | #16 | PACN | Galen Center · Los Angeles, CA |
| 11 | Wed Dec 15 | vsUC Irvine | W66-61 | 11-0 | 1.000 | #10 | | Galen Center · Los Angeles, CA |
| 12 | Sat Dec 18 | vsGeorgia Tech | W67-53 | 12-0 | 1.000 | - | PACN | Mortgage Matchup Center · Phoenix, AZ |
| 14 | Thu Dec 30 | vsArizona St | PPD | 26-8 | .765 | #7 | | Galen Center · Los Angeles, CA |
| 15 | Sun Jan 2 | vs9Arizona | PPD | 26-8 | .765 | #7 | | Galen Center · Los Angeles, CA |
| 16 | Thu Jan 6 | atCalifornia | W77-63 | 13-0 | 1.000 | #7 | FS1 | Haas Pavilion · Berkeley, CA |
| 17 | Sat Jan 8 | atStanford | PPD | 26-8 | .765 | #7 | | Maples Pavilion · Stanford, CA |
| 18 | Tue Jan 11 | atStanford | L69-75 | 13-1 | .929 | #5 | ESPN2 | Maples Pavilion · Stanford, CA |
| 19 | Thu Jan 13 | vsOregon St | W81-71 | 14-1 | .933 | #5 | ESPNU | Galen Center · Los Angeles, CA |
| 20 | Sat Jan 15 | vsOregon | L69-79 | 14-2 | .875 | #5 | FS1 | Galen Center · Los Angeles, CA |
| 21 | Thu Jan 20 | atColorado | W61-58 | 15-2 | .882 | #16 | PACN | CU Events Center · Boulder, CO |
| 22 | Sat Jan 22 | atUtah | W79-67 | 16-2 | .889 | #16 | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 23 | Mon Jan 24 | vsArizona St | W78-56 | 17-2 | .895 | #15 | ESPN | Galen Center · Los Angeles, CA |
| 24 | Thu Jan 27 | vsStanford | L61-64 | 17-3 | .850 | #15 | FS1 | Galen Center · Los Angeles, CA |
| 25 | Sat Jan 29 | vsCalifornia | W79-72 | 18-3 | .857 | #15 | PACN | Galen Center · Los Angeles, CA |
| 26 | Thu Feb 3 | atArizona St | W58-53 | 19-3 | .864 | #19 | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 27 | Sat Feb 5 | at7Arizona | L63-72 | 19-4 | .826 | #19 | FOX | McKale Center · Tucson, AZ |
| 28 | Tue Feb 8 | vsPacific | W74-68 | 20-4 | .833 | #21 | PACN | Galen Center · Los Angeles, CA |
| 29 | Sat Feb 12 | vs12UCLA | W67-64 | 21-4 | .840 | #21 | ESPN | Galen Center · Los Angeles, CA |
| 30 | Thu Feb 17 | vsWashington | W79-69 | 22-4 | .846 | #17 | PACN | Galen Center · Los Angeles, CA |
| 31 | Sun Feb 20 | vsWashington St | W62-60 | 23-4 | .852 | #17 | FS1 | Galen Center · Los Angeles, CA |
| 32 | Thu Feb 24 | atOregon St | W94-91 (2OT) | 24-4 | .857 | #16 | ESPN2 | Gill Coliseum · Corvallis, OR |
| 33 | Sat Feb 26 | atOregon | W70-69 | 25-4 | .862 | #16 | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 34 | Tue Mar 1 | vs2Arizona | L71-91 | 25-5 | .833 | #16 | ESPN | Galen Center · Los Angeles, CA |
| 35 | Sat Mar 5 | at17UCLA | L68-75 | 25-6 | .806 | #16 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 36 | Thu Mar 10 | vsWashington | W65-61 | 26-6 | .813 | - | FS1 | T-Mobile Arena · Las Vegas, NV |
| 37 | Fri Mar 11 | atUCLA | L59-69 | 26-7 | .788 | - | FS1 | T-Mobile Arena · Las Vegas, NV |
| 37 | Fri Mar 18 | vs10Miami | L66-68 | 26-8 | .765 | #7 | truTV | Bon Secours Wellness Arena · Greenville, SC |
