| 1 | Sun Sep 12 | vs Packers | W38-3 | 1-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 19 | at Panthers | L7-26 | 1-1 | .500 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 26 | at Patriots | W28-13 | 2-1 | .667 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Oct 3 | vs Giants | L21-27 (OT) | 2-2 | .500 | Caesars Superdome · New Orleans, LA |
| 5 | Sun Oct 10 | at Commanders | W33-22 | 3-2 | .600 | FedEx Field · North Englewood, MD |
| 6 | -- BYE WEEK -- |
| 7 | Mon Oct 25 | at Seahawks | W13-10 | 4-2 | .667 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 31 | vs Buccaneers | W36-27 | 5-2 | .714 | Caesars Superdome · New Orleans, LA |
| 9 | Sun Nov 7 | vs Falcons | L25-27 | 5-3 | .625 | Caesars Superdome · New Orleans, LA |
| 10 | Sun Nov 14 | at Titans | L21-23 | 5-4 | .556 | Nissan Stadium · Nashville, TN |
| 11 | Sun Nov 21 | at Eagles | L29-40 | 5-5 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Thu Nov 25 | vs Bills | L6-31 | 5-6 | .455 | Caesars Superdome · New Orleans, LA |
| 13 | Thu Dec 2 | vs Cowboys | L17-27 | 5-7 | .417 | Caesars Superdome · New Orleans, LA |
| 14 | Sun Dec 12 | at Jets | W30-9 | 6-7 | .462 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 19 | atBuccaneers | W9-0 | 7-7 | .500 | Raymond James Stadium · Tampa, FL |
| 16 | Mon Dec 27 | vs Dolphins | L3-20 | 7-8 | .467 | Caesars Superdome · New Orleans, LA |
| 17 | Sun Jan 2 | vsPanthers | W18-10 | 8-8 | .500 | Caesars Superdome · New Orleans, LA |
| 18 | Sun Jan 9 | atFalcons | W30-20 | 9-8 | .529 | Mercedes-Benz Stadium · Atlanta, GA |
