| 1 | Mon Nov 7 | vs Miss Valley St | W117-53 | 1-0 | 1.000 | #5 | | Ferrell Center · Waco, TX |
| 2 | Fri Nov 11 | vsNorfolk St | W87-70 | 2-0 | 1.000 | #5 | | Ferrell Center · Waco, TX |
| 3 | Mon Nov 14 | vsN Colorado | W95-62 | 3-0 | 1.000 | #5 | | Ferrell Center · Waco, TX |
| 4 | Fri Nov 18 | vsVirginia | L79-86 | 3-1 | .750 | - | ESPN2 | T-Mobile Arena · Las Vegas, NV |
| 5 | Sun Nov 20 | vsUCLA | W80-75 | 4-1 | .800 | - | ESPN | T-Mobile Arena · Las Vegas, NV |
| 6 | Wed Nov 23 | vsMcNeese | W89-60 | 5-1 | .833 | #7 | | Ferrell Center · Waco, TX |
| 7 | Tue Nov 29 | atMarquette | L70-96 | 5-2 | .714 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 8 | Fri Dec 2 | at14Gonzaga | W64-63 | 6-2 | .750 | #6 | | McCarthey Athletic Center · Spokane, WA |
| 9 | Tue Dec 6 | vsTarleton | W80-57 | 7-2 | .778 | #12 | | Ferrell Center · Waco, TX |
| 10 | Sun Dec 18 | vsWashington St | W65-59 | 8-2 | .800 | - | ESPN2 | Ferrell Center · Waco, TX |
| 11 | Tue Dec 20 | vsN'Western St | W58-48 | 9-2 | .818 | #12 | | Ferrell Center · Waco, TX |
| 12 | Wed Dec 28 | vsNicholls | W85-56 | 10-2 | .833 | #12 | | Ferrell Center · Waco, TX |
| 13 | Sat Dec 31 | atIowa State | L62-77 | 10-3 | .769 | #12 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 14 | Wed Jan 4 | vs17TCU | L87-88 | 10-4 | .714 | #19 | ESPN2 | Ferrell Center · Waco, TX |
| 15 | Sat Jan 7 | vsKansas St | L95-97 (OT) | 10-5 | .667 | #19 | | Ferrell Center · Waco, TX |
| 16 | Wed Jan 11 | atWest Virginia | W83-78 | 11-5 | .688 | - | | WVU Coliseum · Morgantown, WV |
| 17 | Sat Jan 14 | vsOklahoma St | W74-58 | 12-5 | .706 | - | ESPNEWS | Ferrell Center · Waco, TX |
| 18 | Tue Jan 17 | atTexas Tech | W81-74 | 13-5 | .722 | #21 | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 19 | Sat Jan 21 | atOklahoma | W62-60 | 14-5 | .737 | #21 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 20 | Mon Jan 23 | vs9Kansas | W75-69 | 15-5 | .750 | #17 | ESPN | Ferrell Center · Waco, TX |
| 21 | Sat Jan 28 | vsArkansas | W67-64 | 16-5 | .762 | - | ESPN | Ferrell Center · Waco, TX |
| 22 | Mon Jan 30 | at10Texas | L71-76 | 16-6 | .727 | #11 | ESPN | Moody Center · Austin, TX |
| 23 | Sat Feb 4 | vsTexas Tech | W89-62 | 17-6 | .739 | #11 | CBS | Ferrell Center · Waco, TX |
| 24 | Wed Feb 8 | vsOklahoma | W82-72 | 18-6 | .750 | #14 | ESPNU | Ferrell Center · Waco, TX |
| 25 | Sat Feb 11 | at17TCU | W72-68 | 19-6 | .760 | #14 | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 26 | Mon Feb 13 | vsWest Virginia | W79-67 | 20-6 | .769 | #9 | ESPN2 | Ferrell Center · Waco, TX |
| 27 | Sat Feb 18 | at5Kansas | L71-87 | 20-7 | .741 | #9 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 21 | at14Kansas St | L65-75 | 20-8 | .714 | #9 | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 29 | Sat Feb 25 | vs8Texas | W81-72 | 21-8 | .724 | #9 | ESPN | Ferrell Center · Waco, TX |
| 30 | Mon Feb 27 | atOklahoma St | W74-68 | 22-8 | .733 | #7 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 4 | vsIowa State | L58-73 | 22-9 | .710 | #7 | ESPN2 | Ferrell Center · Waco, TX |
| 32 | Thu Mar 9 | vsIowa State | L72-78 | 22-10 | .688 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 33 | Fri Mar 17 | vs14UCSB | W74-56 | 23-10 | .697 | #3 | TNT | Ferrell Center · Waco, TX |
| 34 | Sun Mar 19 | vs6Creighton | L76-85 | 23-11 | .676 | #3 | TBS | Ferrell Center · Waco, TX |
