| 1 | Tue Nov 7 | vs Auburn | W88-82 | 1-0 | 1.000 | #20 | ESPN | Ferrell Center · Waco, TX |
| 2 | Thu Nov 9 | vsTBD | W96-70 | 2-0 | 1.000 | #20 | | Ferrell Center · Waco, TX |
| 3 | Sun Nov 12 | vsGardner-Webb | W77-62 | 3-0 | 1.000 | #20 | | Ferrell Center · Waco, TX |
| 4 | Tue Nov 14 | vsKansas City | W99-61 | 4-0 | 1.000 | #15 | | Ferrell Center · Waco, TX |
| 5 | Wed Nov 22 | atOregon St | W88-72 | 5-0 | 1.000 | #13 | ESPN2 | Gill Coliseum · Corvallis, OR |
| 6 | Fri Nov 24 | atFlorida | W95-91 | 6-0 | 1.000 | #13 | ESPN | O'Connell Center · Gainesville, FL |
| 7 | Tue Nov 28 | vsNicholls | W108-70 | 7-0 | 1.000 | #9 | | Ferrell Center · Waco, TX |
| 8 | Sat Dec 2 | vsN'Western St | W91-40 | 8-0 | 1.000 | #9 | | Ferrell Center · Waco, TX |
| 9 | Tue Dec 5 | vsSeton Hall | W78-60 | 9-0 | 1.000 | #6 | ESPN2 | Ferrell Center · Waco, TX |
| 10 | Sat Dec 16 | atMichigan St | L64-88 | 9-1 | .900 | #6 | FOX | Breslin Center · East Lansing, MI |
| 11 | Wed Dec 20 | at#21Duke | L70-78 | 9-2 | .818 | #10 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 12 | Fri Dec 22 | vsMiss Valley St | W107-48 | 10-2 | .833 | #10 | | Ferrell Center · Waco, TX |
| 13 | Tue Jan 2 | vsCornell | W98-79 | 11-2 | .846 | #18 | | Ferrell Center · Waco, TX |
| 14 | Sat Jan 6 | atOklahoma St | W75-70 (OT) | 12-2 | .857 | #18 | | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Tue Jan 9 | vs#18BYU | W81-72 | 13-2 | .867 | #14 | | Ferrell Center · Waco, TX |
| 16 | Sat Jan 13 | vsCincinnati | W62-59 | 14-2 | .875 | #14 | ESPN | Ferrell Center · Waco, TX |
| 17 | Tue Jan 16 | atKansas St | L64-68 (OT) | 14-3 | .824 | #9 | | Bramlage Coliseum · Manhattan, KS |
| 18 | Sat Jan 20 | atTexas | L73-75 | 14-4 | .778 | #9 | ESPN | Moody Center · Austin, TX |
| 19 | Sat Jan 27 | vsTCU | L102-105 (3OT) | 14-5 | .737 | #15 | ESPN2 | Ferrell Center · Waco, TX |
| 20 | Wed Jan 31 | atUCF | W77-69 | 15-5 | .750 | #18 | | Addition Financial Arena · Orlando, FL |
| 21 | Sat Feb 3 | vs#12Iowa State | W70-68 | 16-5 | .762 | #18 | ESPN2 | Ferrell Center · Waco, TX |
| 22 | Tue Feb 6 | vs#23Texas Tech | W79-73 | 17-5 | .773 | #13 | ESPN | Ferrell Center · Waco, TX |
| 23 | Sat Feb 10 | at#4Kansas | L61-64 | 17-6 | .739 | #13 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Tue Feb 13 | vs#25Oklahoma | W79-62 | 18-6 | .750 | #12 | ESPN2 | Ferrell Center · Waco, TX |
| 25 | Sat Feb 17 | atWest Virginia | W94-81 | 19-6 | .760 | #12 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 26 | Tue Feb 20 | at#25BYU | L71-78 | 19-7 | .731 | #11 | ESPN | Marriott Center · Provo, UT |
| 27 | Sat Feb 24 | vs#2Houston | L76-82 (OT) | 19-8 | .704 | #11 | CBS | Ferrell Center · Waco, TX |
| 28 | Mon Feb 26 | atTCU | W62-54 | 20-8 | .714 | #15 | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 29 | Sat Mar 2 | vs#7Kansas | W82-74 | 21-8 | .724 | #15 | ABC | Ferrell Center · Waco, TX |
| 30 | Mon Mar 4 | vsTexas | W93-85 | 22-8 | .733 | #11 | ESPN | Ferrell Center · Waco, TX |
| 31 | Sat Mar 9 | atTexas Tech | L68-78 | 22-9 | .710 | #11 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 32 | Thu Mar 14 | vsCincinnati | W68-56 | 23-9 | .719 | #14 | ESPN2 | Ferrell Center · Waco, TX |
| 33 | Fri Mar 15 | at#7Iowa State | L62-76 | 23-10 | .697 | #14 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 34 | Fri Mar 22 | vs#14Colgate | W92-67 | 24-10 | .706 | #3 | truTV | FedExForum · Memphis, TN |
| 35 | Sun Mar 24 | vs#6Clemson | L64-72 | 24-11 | .686 | #3 | TNT | FedExForum · Memphis, TN |
