| 1 | Mon Nov 4 | at 6Gonzaga | L63-101 | 0-1 | .000 | #8 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 2 | Sat Nov 9 | at16Arkansas | W72-67 | 1-1 | .500 | #8 | ESPNU | Bud Walton Arena · Fayetteville, AR |
| 3 | Tue Nov 12 | vsSam Houston | W104-67 | 2-1 | .667 | #12 | ESPN+ | Ferrell Center · Waco, TX |
| 4 | Sun Nov 17 | vsTarleton | W104-41 | 3-1 | .750 | #12 | ESPN+ | Ferrell Center · Waco, TX |
| 5 | Thu Nov 21 | at22St John's | W99-98 (2OT) | 4-1 | .800 | #13 | CBSSN | Carnesecca Arena · Queens, NY |
| 6 | Fri Nov 22 | vs11Tennessee | L62-77 | 4-2 | .667 | #13 | CBSSN | Ferrell Center · Waco, TX |
| 7 | Wed Nov 27 | vsNew Orleans | W91-60 | 5-2 | .714 | #17 | ESPN+ | Ferrell Center · Waco, TX |
| 8 | Wed Dec 4 | at25UConn | L72-76 | 5-3 | .625 | #15 | FS1 | Gampel Pavilion · Storrs, CT |
| 9 | Mon Dec 9 | vsAbilene Chrstn | W88-57 | 6-3 | .667 | - | CBSSN | Ferrell Center · Waco, TX |
| 10 | Wed Dec 11 | vsNorfolk St | W94-69 | 7-3 | .700 | - | ESPN+ | Ferrell Center · Waco, TX |
| 11 | Fri Dec 27 | vsTBD | W107-53 | 8-3 | .727 | #25 | ESPN+ | Ferrell Center · Waco, TX |
| 12 | Tue Dec 31 | vsUtah | W81-56 | 9-3 | .750 | #25 | ESPN+ | Ferrell Center · Waco, TX |
| 13 | Sat Jan 4 | at3Iowa State | L55-74 | 9-4 | .692 | #25 | CBS | James H. Hilton Coliseum · Ames, IA |
| 14 | Tue Jan 7 | vsCincinnati | W68-48 | 10-4 | .714 | - | ESPN+ | Ferrell Center · Waco, TX |
| 15 | Sat Jan 11 | atArizona St | W72-66 (OT) | 11-4 | .733 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 16 | Tue Jan 14 | atArizona | L70-81 | 11-5 | .688 | #25 | ESPN | McKale Center · Tucson, AZ |
| 17 | Sun Jan 19 | vsTCU | L71-74 | 11-6 | .647 | #25 | ESPN | Ferrell Center · Waco, TX |
| 18 | Wed Jan 22 | vsKansas St | W70-62 | 12-6 | .667 | - | ESPNU | Ferrell Center · Waco, TX |
| 19 | Sat Jan 25 | atUtah | W76-61 | 13-6 | .684 | - | ESPN2 | Jon M. Huntsman Center · Salt Lake City, UT |
| 20 | Tue Jan 28 | atBYU | L89-93 (OT) | 13-7 | .650 | - | ESPN2 | Marriott Center · Provo, UT |
| 21 | Sat Feb 1 | vs11Kansas | W81-70 | 14-7 | .667 | - | ESPN | Ferrell Center · Waco, TX |
| 22 | Tue Feb 4 | at13Texas Tech | L59-73 | 14-8 | .636 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 8 | vsUCF | W91-76 | 15-8 | .652 | - | ESPN+ | Ferrell Center · Waco, TX |
| 24 | Mon Feb 10 | at6Houston | L65-76 | 15-9 | .625 | - | ESPNU | Fertitta Center · Houston, TX |
| 25 | Sat Feb 15 | vsWest Virginia | W74-71 (OT) | 16-9 | .640 | - | ESPN2 | Ferrell Center · Waco, TX |
| 26 | Mon Feb 17 | vs19Arizona | L67-74 | 16-10 | .615 | - | ESPN | Ferrell Center · Waco, TX |
| 27 | Sat Feb 22 | atColorado | L74-76 | 16-11 | .593 | - | ESPN+ | CU Events Center · Boulder, CO |
| 28 | Tue Feb 25 | atCincinnati | L67-69 | 16-12 | .571 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 29 | Sat Mar 1 | vsOklahoma St | W71-61 | 17-12 | .586 | - | ESPN+ | Ferrell Center · Waco, TX |
| 30 | Tue Mar 4 | atTCU | W61-58 | 18-12 | .600 | - | ESPN+ | Schollmaier Arena · Fort Worth, TX |
| 31 | Sat Mar 8 | vs3Houston | L61-65 | 18-13 | .581 | - | ESPN | Ferrell Center · Waco, TX |
| 32 | Wed Mar 12 | vsKansas St | W70-56 | 19-13 | .594 | - | ESPN+ | T-Mobile Center · Kansas City, MOS |
| 33 | Thu Mar 13 | at9Texas Tech | L74-76 | 19-14 | .576 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 34 | Fri Mar 21 | at8Mississippi St | W75-72 | 20-14 | .588 | #9 | CBS | PNC Arena · Raleigh, NC |
| 35 | Sun Mar 23 | at1Duke | L66-89 | 20-15 | .571 | #9 | CBS | PNC Arena · Raleigh, NC |
