| 1 | Fri Nov 12 | vs Incarnate Word | W87-60 | 1-0 | 1.000 | #8 | | Ferrell Center · Waco, TX |
| 2 | Mon Nov 15 | vs Nicholls | W89-60 | 2-0 | 1.000 | #9 | | Ferrell Center · Waco, TX |
| 3 | Wed Nov 17 | vs C Arkansas | W92-47 | 3-0 | 1.000 | #9 | | Ferrell Center · Waco, TX |
| 4 | Sat Nov 20 | vs Stanford | W86-48 | 4-0 | 1.000 | #9 | | Ferrell Center · Waco, TX |
| 5 | Wed Nov 24 | vs Arizona St | W75-63 | 5-0 | 1.000 | - | ESPN2 | Ferrell Center · Waco, TX |
| 6 | Thu Nov 25 | at VCU | W69-61 | 6-0 | 1.000 | - | ESPN | Stuart C. Siegel Center · Richmond, VA |
| 7 | Fri Nov 26 | at Michigan St | W75-58 | 7-0 | 1.000 | - | ESPN | Breslin Center · East Lansing, MI |
| 8 | Sat Dec 4 | vs AR-Pine Bluff | W99-54 | 8-0 | 1.000 | #4 | | Ferrell Center · Waco, TX |
| 9 | Sun Dec 12 | vs Villanova | W57-36 | 9-0 | 1.000 | - | ABC | Ferrell Center · Waco, TX |
| 10 | Sat Dec 18 | at Oregon | W78-70 | 10-0 | 1.000 | #1 | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 11 | Mon Dec 20 | vs Alcorn St | W94-57 | 11-0 | 1.000 | #1 | | Ferrell Center · Waco, TX |
| 12 | Tue Dec 28 | vs N'Western St | W104-68 | 12-0 | 1.000 | #1 | | Ferrell Center · Waco, TX |
| 13 | Sat Jan 1 | at #8Iowa State | W77-72 | 13-0 | 1.000 | #1 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 14 | Tue Jan 4 | vs Oklahoma | W84-74 | 14-0 | 1.000 | #1 | ESPN2 | Ferrell Center · Waco, TX |
| 15 | Sat Jan 8 | at TCU | W76-64 | 15-0 | 1.000 | #1 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Tue Jan 11 | vs #19Texas Tech | L62-65 | 15-1 | .938 | #1 | ESPN2 | Ferrell Center · Waco, TX |
| 17 | Sat Jan 15 | vs Oklahoma St | L54-61 | 15-2 | .882 | #1 | ESPN | Ferrell Center · Waco, TX |
| 18 | Tue Jan 18 | at West Virginia | W77-68 | 16-2 | .889 | #5 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 22 | atOklahoma | W65-51 | 17-2 | .895 | #5 | | Lloyd Noble Center · Norman, OK |
| 20 | Tue Jan 25 | vs Kansas St | W74-49 | 18-2 | .900 | #4 | | Ferrell Center · Waco, TX |
| 21 | Sat Jan 29 | at Alabama | L78-87 | 18-3 | .857 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 22 | Mon Jan 31 | vsWest Virginia | W81-77 | 19-3 | .864 | #8 | ESPN | Ferrell Center · Waco, TX |
| 23 | Sat Feb 5 | at #10Kansas | L59-83 | 19-4 | .826 | #8 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Wed Feb 9 | atKansas St | W75-60 | 20-4 | .833 | #10 | | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 12 | vs #20Texas | W80-63 | 21-4 | .840 | #10 | ESPN2 | Ferrell Center · Waco, TX |
| 26 | Wed Feb 16 | at#11Texas Tech | L73-83 | 21-5 | .808 | #7 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 19 | vsTCU | W72-62 | 22-5 | .815 | #7 | ESPN2 | Ferrell Center · Waco, TX |
| 28 | Mon Feb 21 | atOklahoma St | W66-64 (OT) | 23-5 | .821 | #10 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Feb 26 | vs#5Kansas | W80-70 | 24-5 | .828 | #10 | ESPN | Ferrell Center · Waco, TX |
| 30 | Mon Feb 28 | at#21Texas | W68-61 | 25-5 | .833 | #3 | ESPN | Moody Center · Austin, TX |
| 31 | Sat Mar 5 | vsIowa State | W75-68 | 26-5 | .839 | #3 | ESPN2 | Ferrell Center · Waco, TX |
| 32 | Thu Mar 10 | vsOklahoma | L67-72 | 26-6 | .813 | - | ESPN | Ferrell Center · Waco, TX |
| 33 | Thu Mar 17 | vs #16Norfolk St | W85-49 | 27-6 | .818 | #1 | TBS | Ferrell Center · Waco, TX |
| 34 | Sat Mar 19 | vs #8UNC | L86-93 (OT) | 27-7 | .794 | #1 | CBS | Ferrell Center · Waco, TX |
