| 1 | Sat Nov 28 | vs Louisiana | W112-82 | 1-0 | 1.000 | - | | T-Mobile Arena · Las Vegas, NV |
| 2 | Sun Nov 29 | vsWashington | W86-52 | 2-0 | 1.000 | #2 | | T-Mobile Arena · Las Vegas, NV |
| 3 | Wed Dec 2 | vsIllinois | W82-69 | 3-0 | 1.000 | - | ESPN | Ferrell Center · Waco, TX |
| 6 | Wed Dec 9 | vsSF Austin | W83-52 | 4-0 | 1.000 | - | | Ferrell Center · Waco, TX |
| 9 | Sat Dec 19 | atKansas St | W100-69 | 5-0 | 1.000 | #2 | | Bramlage Coliseum · Manhattan, KS |
| 10 | Mon Dec 21 | vsAR-Pine Bluff | W99-42 | 6-0 | 1.000 | #2 | | Ferrell Center · Waco, TX |
| 11 | Tue Dec 29 | vsC Arkansas | W93-56 | 7-0 | 1.000 | #2 | | Ferrell Center · Waco, TX |
| 12 | Wed Dec 30 | vsAlcorn St | W105-76 | 8-0 | 1.000 | #2 | | Ferrell Center · Waco, TX |
| 13 | Sat Jan 2 | atIowa State | W76-65 | 9-0 | 1.000 | #2 | | James H. Hilton Coliseum · Ames, IA |
| 14 | Wed Jan 6 | vsOklahoma | W76-61 | 10-0 | 1.000 | #2 | ESPN2 | Ferrell Center · Waco, TX |
| 15 | Sat Jan 9 | atTCU | W67-49 | 11-0 | 1.000 | #2 | ESPN | Schollmaier Arena · Fort Worth, TX |
| 17 | Sat Jan 16 | at15Texas Tech | W68-60 | 12-0 | 1.000 | #2 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 18 | Mon Jan 18 | vs9Kansas | W77-69 | 13-0 | 1.000 | #2 | ESPN | Ferrell Center · Waco, TX |
| 19 | Sat Jan 23 | atOklahoma St | W81-66 | 14-0 | 1.000 | #2 | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Wed Jan 27 | vsKansas St | W107-59 | 15-0 | 1.000 | #2 | ESPN2 | Ferrell Center · Waco, TX |
| 21 | Sat Jan 30 | vsAuburn | W84-72 | 16-0 | 1.000 | - | ESPN | Ferrell Center · Waco, TX |
| 22 | Tue Feb 2 | at6Texas | W83-69 | 17-0 | 1.000 | #2 | ESPN | Moody Center · Austin, TX |
| 25 | Sat Feb 13 | vs7Texas Tech | PPD | 28-2 | .933 | #2 | ESPN | Ferrell Center · Waco, TX |
| 26 | Mon Feb 15 | at13West Virginia | PPD | 28-2 | .933 | #2 | ESPN | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 20 | vsOklahoma St | PPD | 28-2 | .933 | #2 | | Ferrell Center · Waco, TX |
| 28 | Tue Feb 23 | vsIowa State | W77-72 | 18-0 | 1.000 | #2 | | Ferrell Center · Waco, TX |
| 30 | Sat Feb 27 | at17Kansas | L58-71 | 18-1 | .947 | #2 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 31 | Tue Mar 2 | at6West Virginia | W94-89 (OT) | 19-1 | .950 | #3 | ESPN | WVU Coliseum · Morgantown, WV |
| 32 | Thu Mar 4 | vs17Oklahoma St | W81-70 | 20-1 | .952 | #3 | ESPN2 | Ferrell Center · Waco, TX |
| 33 | Sun Mar 7 | vsTexas Tech | W88-73 | 21-1 | .955 | - | ESPN | Ferrell Center · Waco, TX |
| 34 | Thu Mar 11 | vsKansas St | W74-68 | 22-1 | .957 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 35 | Fri Mar 12 | vsOklahoma St | L74-83 | 22-2 | .917 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 28 | Fri Mar 19 | vs16TBD | W79-55 | 23-2 | .920 | #1 | truTV | Lucas Oil Stadium · Indianapolis, IN |
| 29 | Sun Mar 21 | vs9Wisconsin | W76-63 | 24-2 | .923 | #1 | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 30 | Sat Mar 27 | vs5Villanova | W62-51 | 25-2 | .926 | #1 | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Mon Mar 29 | vs3Arkansas | W81-72 | 26-2 | .929 | #1 | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 32 | Sat Apr 3 | vs2Houston | W78-59 | 27-2 | .931 | #1 | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 33 | Mon Apr 5 | at1Gonzaga | W86-70 | 28-2 | .933 | #1 | CBS | Lucas Oil Stadium · Indianapolis, IN |
