| 1 | Tue Nov 5 | vs C Arkansas | W105-61 | 1-0 | 1.000 | #16 | | Ferrell Center · Waco, TX |
| 2 | Fri Nov 8 | vsWashington | L64-67 | 1-1 | .500 | - | ESPN | Ferrell Center · Waco, TX |
| 3 | Fri Nov 15 | vsTexas St | W72-63 | 2-1 | .667 | #24 | | Ferrell Center · Waco, TX |
| 4 | Thu Nov 21 | vsOhio | W76-53 | 3-1 | .750 | - | ESPN2 | The HTC Center · Conway, SC |
| 5 | Fri Nov 22 | atCoast Car | W77-65 | 4-1 | .800 | - | ESPNU | The HTC Center · Conway, SC |
| 6 | Sun Nov 24 | vsVillanova | W87-78 | 5-1 | .833 | - | ESPN | The HTC Center · Conway, SC |
| 7 | Tue Dec 3 | vsMD-Eastern | W78-46 | 6-1 | .857 | #18 | | Ferrell Center · Waco, TX |
| 8 | Sat Dec 7 | vs12Arizona | W63-58 | 7-1 | .875 | #18 | ESPNU | Ferrell Center · Waco, TX |
| 9 | Tue Dec 10 | vs18Butler | W53-52 | 8-1 | .889 | #11 | ESPN2 | Ferrell Center · Waco, TX |
| 10 | Wed Dec 18 | vsUT Martin | W91-63 | 9-1 | .900 | - | ESPNU | Toyota Center · Houston, TX |
| 11 | Mon Dec 30 | vsJackson St | W83-57 | 10-1 | .909 | #6 | | Ferrell Center · Waco, TX |
| 12 | Sat Jan 4 | vsTexas | W59-44 | 11-1 | .917 | #6 | ESPN2 | Ferrell Center · Waco, TX |
| 13 | Tue Jan 7 | at22Texas Tech | W57-52 | 12-1 | .923 | #4 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 14 | Sat Jan 11 | at3Kansas | W67-55 | 13-1 | .929 | #4 | CBS | Allen Fieldhouse · Lawrence, KS |
| 15 | Wed Jan 15 | vsIowa State | W68-55 | 14-1 | .933 | #2 | | Ferrell Center · Waco, TX |
| 16 | Sat Jan 18 | atOklahoma St | W75-68 | 15-1 | .938 | #2 | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 17 | Mon Jan 20 | vsOklahoma | W61-57 | 16-1 | .941 | #1 | ESPN | Ferrell Center · Waco, TX |
| 18 | Sat Jan 25 | atFlorida | W72-61 | 17-1 | .944 | - | ESPN | O'Connell Center · Gainesville, FL |
| 19 | Wed Jan 29 | atIowa State | W67-53 | 18-1 | .947 | #1 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 20 | Sat Feb 1 | vsTCU | W68-52 | 19-1 | .950 | #1 | ESPN2 | Ferrell Center · Waco, TX |
| 21 | Mon Feb 3 | atKansas St | W73-67 | 20-1 | .952 | #1 | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 22 | Sat Feb 8 | vsOklahoma St | W78-70 | 21-1 | .955 | #1 | ESPN2 | Ferrell Center · Waco, TX |
| 23 | Mon Feb 10 | atTexas | W52-45 | 22-1 | .957 | #1 | ESPN | Moody Center · Austin, TX |
| 24 | Sat Feb 15 | vs14West Virginia | W70-59 | 23-1 | .958 | #1 | | Ferrell Center · Waco, TX |
| 25 | Tue Feb 18 | atOklahoma | W65-54 | 24-1 | .960 | #1 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 26 | Sat Feb 22 | vs3Kansas | L61-64 | 24-2 | .923 | #1 | ESPN | Ferrell Center · Waco, TX |
| 27 | Tue Feb 25 | vsKansas St | W85-66 | 25-2 | .926 | #2 | | Ferrell Center · Waco, TX |
| 28 | Sat Feb 29 | atTCU | L72-75 | 25-3 | .893 | #2 | ESPN | Schollmaier Arena · Fort Worth, TX |
| 29 | Mon Mar 2 | vsTexas Tech | W71-68 (OT) | 26-3 | .897 | #4 | ESPN | Ferrell Center · Waco, TX |
| 30 | Sat Mar 7 | atWest Virginia | L64-76 | 26-4 | .867 | #4 | | WVU Coliseum · Morgantown, WV |
