| 1 | Mon Nov 7 | vs Stetson | L74-83 | 0-1 | .000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Fri Nov 11 | atUCF | L54-68 | 0-2 | .000 | - | | Addition Financial Arena · Orlando, FL |
| 3 | Mon Nov 14 | vsTroy | L72-79 | 0-3 | .000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 4 | Fri Nov 18 | vsFlorida | L67-76 | 0-4 | .000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Mon Nov 21 | vsMercer | W81-72 | 1-4 | .200 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Thu Nov 24 | atSiena | L63-80 | 1-5 | .167 | - | ESPN2 | MVP Arena · Albany, NY |
| 7 | Fri Nov 25 | atStanford | L60-70 | 1-6 | .143 | - | ESPNEWS | Maples Pavilion · Stanford, CA |
| 8 | Sun Nov 27 | atNebraska | L58-75 | 1-7 | .125 | - | ESPNEWS | Pinnacle Bank Arena · Lincoln, NE |
| 9 | Wed Nov 30 | vsPurdue | L69-79 | 1-8 | .111 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 10 | Sat Dec 3 | at#3Virginia | L57-62 | 1-9 | .100 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 11 | Sat Dec 10 | vsLouisville | W75-53 | 2-9 | .182 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Tue Dec 13 | vsSC Upstate | W80-63 | 3-9 | .250 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Sat Dec 17 | vsSt John's | L79-93 | 3-10 | .231 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Wed Dec 21 | vsNotre Dame | W73-72 | 4-10 | .286 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Sat Dec 31 | at#17Duke | L67-86 | 4-11 | .267 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 16 | Sat Jan 7 | vsGeorgia Tech | W75-64 | 5-11 | .313 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 17 | Wed Jan 11 | atWake Forest | L75-90 | 5-12 | .294 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Sat Jan 14 | vs#13Virginia | L58-67 | 5-13 | .278 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 19 | Tue Jan 17 | atNotre Dame | W84-71 | 6-13 | .316 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 20 | Sat Jan 21 | atPitt | W71-64 | 7-13 | .350 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 24 | vs#20Miami | L63-86 | 7-14 | .333 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 22 | Sat Jan 28 | vs#24Clemson | L81-82 | 7-15 | .318 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Wed Feb 1 | atNC State | L66-94 | 7-16 | .304 | - | ACC Network | PNC Arena · Raleigh, NC |
| 24 | Sat Feb 4 | atLouisville | W81-78 | 8-16 | .333 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 25 | Wed Feb 8 | vsSyracuse | L67-76 | 8-17 | .320 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Sat Feb 11 | vsPitt | L75-83 | 8-18 | .308 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Wed Feb 15 | atClemson | L54-94 | 8-19 | .296 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Sat Feb 18 | vsBoston College | L69-75 | 8-20 | .286 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Feb 25 | at#13Miami | W85-84 | 9-20 | .310 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 30 | Mon Feb 27 | vsUNC | L66-77 | 9-21 | .300 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 31 | Sat Mar 4 | atVirginia Tech | L60-82 | 9-22 | .290 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 32 | Tue Mar 7 | vsGeorgia Tech | L60-61 | 9-23 | .281 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
