| 1 | Fri Nov 10 | vs Kennesaw St | W94-67 | 1-0 | 1.000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Mon Nov 13 | vs C Michigan | W94-67 | 2-0 | 1.000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 3 | Fri Nov 17 | at Florida | L68-89 | 2-1 | .667 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 4 | Mon Nov 20 | at UNLV | W83-75 | 3-1 | .750 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 5 | Tue Nov 21 | at #18Colorado | W77-71 (OT) | 4-1 | .800 | - | CBS | CU Events Center · Boulder, CO |
| 6 | Wed Nov 29 | vs Georgia | L66-68 | 4-2 | .667 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Sat Dec 2 | at #17UNC | L70-78 | 4-3 | .571 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Sat Dec 9 | vs South Florida | L72-88 | 4-4 | .500 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 9 | Sat Dec 16 | vs SMU | L57-68 | 4-5 | .444 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 10 | Tue Dec 19 | vs North Florida | W91-75 | 5-5 | .500 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 11 | Fri Dec 22 | vs Winthrop | W67-61 | 6-5 | .545 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Sat Dec 30 | vs Lipscomb | L75-78 | 6-6 | .500 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Wed Jan 3 | vs Georgia Tech | W82-71 | 7-6 | .538 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Sat Jan 6 | vs Virginia Tech | W77-74 | 8-6 | .571 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Tue Jan 9 | vs Wake Forest | W87-82 | 9-6 | .600 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 13 | at Notre Dame | W67-58 | 10-6 | .625 | - | The CW Network | Purcell Pavilion · South Bend, IN |
| 17 | Wed Jan 17 | at Miami | W84-75 | 11-6 | .647 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 18 | Sat Jan 20 | vs Clemson | L67-78 | 11-7 | .611 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 19 | Tue Jan 23 | at Syracuse | W85-69 | 12-7 | .632 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 20 | Sat Jan 27 | vs#3UNC | L68-75 | 12-8 | .600 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 21 | Sat Feb 3 | at Louisville | L92-101 | 12-9 | .571 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 22 | Tue Feb 6 | at Boston College | W63-62 | 13-9 | .591 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Sat Feb 10 | vs Virginia | L76-80 | 13-10 | .565 | - | The CW Network | Donald L. Tucker Center · Tallahassee, FL |
| 24 | Tue Feb 13 | atVirginia Tech | L75-83 | 13-11 | .542 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 25 | Sat Feb 17 | vs #9Duke | L67-76 | 13-12 | .520 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Tue Feb 20 | vsBoston College | W84-76 | 14-12 | .538 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 24 | atClemson | L63-74 | 14-13 | .519 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Tue Feb 27 | vs NC State | W90-83 | 15-13 | .536 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Mar 2 | atGeorgia Tech | L76-85 | 15-14 | .517 | - | ESPN2 | McCamish Pavilion · Atlanta, GA |
| 30 | Tue Mar 5 | at Pitt | L73-88 | 15-15 | .500 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 9 | vsMiami | W83-75 | 16-15 | .516 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 32 | Wed Mar 13 | atVirginia Tech | W86-76 | 17-15 | .531 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 33 | Thu Mar 14 | at#4UNC | L67-92 | 17-16 | .515 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
