| 3 | Tue Nov 11 | at #3Florida | 7:00 PM | 1-1 | .500 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 4 | Tue Nov 18 | vsUT Martin | 7:00 PM | 1-0 | 1.000 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Fri Nov 21 | vsGeorgia So | 6:00 PM | 0-1 | .000 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Tue Nov 25 | vsBakersfield | 7:00 PM | 1-1 | .500 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Fri Nov 28 | vsTexas A&M | 5:00 PM | 2-0 | 1.000 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 8 | Tue Dec 2 | vsGeorgia | 9:00 PM | 2-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 9 | Sat Dec 6 | at#2Houston | 8:00 PM | 1-0 | 1.000 | - | Peacock | Fertitta Center · Houston, TX |
| 10 | Sat Dec 13 | vsUMass | 12:00 PM | 0-1 | .000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 11 | Tue Dec 16 | atDayton | 7:00 PM | 1-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 12 | Fri Dec 19 | vsMiss Valley St | 7:00 PM | 1-2 | .333 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Mon Dec 22 | vsJacksonville | 7:00 PM | 1-1 | .500 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Tue Dec 30 | at#25UNC | 7:00 PM | 2-0 | 1.000 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sat Jan 3 | vs#6Duke | 3:45 PM | 1-0 | 1.000 | - | CBS | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 10 | vsNC State | 12:00 PM | 2-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 17 | Tue Jan 13 | atSyracuse | 9:00 PM | 1-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 17 | vsWake Forest | 6:00 PM | 2-0 | 1.000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 19 | Tue Jan 20 | atMiami | 7:00 PM | 2-0 | 1.000 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 20 | Sat Jan 24 | atSMU | 4:00 PM | 2-0 | 1.000 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 21 | Wed Jan 28 | vsCalifornia | 7:00 PM | 2-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 22 | Sat Jan 31 | vsStanford | 6:00 PM | 1-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Sat Feb 7 | atNotre Dame | 4:00 PM | 2-0 | 1.000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 24 | Tue Feb 10 | vsVirginia | 7:00 PM | 2-0 | 1.000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 25 | Sat Feb 14 | atVirginia Tech | 2:00 PM | 1-0 | 1.000 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Tue Feb 17 | vsBoston College | 6:00 PM | 1-1 | .500 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 21 | atClemson | 12:00 PM | 2-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Tue Feb 24 | vsMiami | 9:00 PM | 2-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Feb 28 | atGeorgia Tech | 12:00 PM | 2-0 | 1.000 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 30 | Wed Mar 4 | atPitt | 9:00 PM | 2-0 | 1.000 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 7 | vsSMU | 2:00 PM | 2-0 | 1.000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
