| 1 | Tue Nov 4 | vs Alcorn St | TBD | 11-21 | .344 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Fri Nov 7 | vsAlabama St | TBD | 20-16 | .556 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 3 | Tue Nov 11 | at#3Florida | 7:00 PM | 36-4 | .900 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 4 | Tue Nov 18 | vsUT Martin | 7:00 PM | 14-19 | .424 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Fri Nov 21 | vsGeorgia So | 7:00 PM | 17-16 | .515 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Tue Nov 25 | vsBakersfield | TBD | 14-19 | .424 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Fri Nov 28 | vsTexas A&M | 5:00 PM | 23-11 | .676 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 8 | Tue Dec 2 | vsGeorgia | 9:00 PM | 20-13 | .606 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 9 | Sat Dec 6 | at#2Houston | 8:00 PM | 35-5 | .875 | - | Peacock | Fertitta Center · Houston, TX |
| 10 | Sat Dec 13 | vsUMass | 12:00 PM | 12-20 | .375 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 11 | Tue Dec 16 | atDayton | TBD | 23-11 | .676 | - | | UD Arena · Dayton, OH |
| 12 | Fri Dec 19 | vsMiss Valley St | TBD | 3-28 | .097 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Mon Dec 22 | vsJacksonville | TBD | 19-14 | .576 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Tue Dec 30 | at#25UNC | 7:00 PM | 23-14 | .622 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sat Jan 3 | vs#6Duke | TBD | 35-4 | .897 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 10 | vsNC State | 12:00 PM | 12-19 | .387 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 17 | Tue Jan 13 | atSyracuse | 9:00 PM | 14-19 | .424 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 17 | vsWake Forest | TBD | 21-11 | .656 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 19 | Tue Jan 20 | atMiami | 7:00 PM | 7-24 | .226 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 20 | Sat Jan 24 | atSMU | 4:00 PM | 24-11 | .686 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 21 | Wed Jan 28 | vsCalifornia | 7:00 PM | 14-19 | .424 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 22 | Sat Jan 31 | vsStanford | 6:00 PM | 21-14 | .600 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Sat Feb 7 | atNotre Dame | 4:00 PM | 15-18 | .455 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 24 | Tue Feb 10 | vsVirginia | TBD | 15-17 | .469 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 25 | Sat Feb 14 | atVirginia Tech | 2:00 PM | 13-19 | .406 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Tue Feb 17 | vsBoston College | 6:00 PM | 12-19 | .387 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 21 | atClemson | TBD | 27-7 | .794 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Tue Feb 24 | vsMiami | 9:00 PM | 7-24 | .226 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Feb 28 | atGeorgia Tech | 12:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 30 | Wed Mar 4 | atPitt | 9:00 PM | 17-15 | .531 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 7 | vsSMU | 2:00 PM | 24-11 | .686 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
