| 1 | Wed Nov 6 | at Pitt | L61-63 | 0-1 | .000 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 2 | Sun Nov 10 | at6Florida | W63-51 | 1-1 | .500 | - | ESPN | O'Connell Center · Gainesville, FL |
| 3 | Fri Nov 15 | vsW Carolina | W79-74 | 2-1 | .667 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 4 | Wed Nov 20 | vsChattanooga | W89-53 | 3-1 | .750 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Sat Nov 23 | vsSt Francis PA | W80-65 | 4-1 | .800 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Mon Nov 25 | vsChicago St | W113-56 | 5-1 | .833 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Fri Nov 29 | atTennessee | W60-57 | 6-1 | .857 | - | CBSSN | Thompson-Boling Arena · Knoxville, TN |
| 8 | Sat Nov 30 | atPurdue | W63-60 (OT) | 7-1 | .875 | - | | Mackey Arena · West Lafayette, IN |
| 9 | Tue Dec 3 | atIndiana | L64-80 | 7-2 | .778 | - | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Sun Dec 8 | vsClemson | W72-53 | 8-2 | .800 | #17 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 11 | Tue Dec 17 | vsNorth Florida | W98-81 | 9-2 | .818 | #19 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Sat Dec 21 | vsSouth Florida | W66-60 | 10-2 | .833 | - | FS2 | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Sat Dec 28 | vsNorth Alabama | W88-71 | 11-2 | .846 | #17 | | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Tue Dec 31 | vsGeorgia Tech | W70-58 | 12-2 | .857 | #18 | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Sat Jan 4 | at7Louisville | W78-65 | 13-2 | .867 | #18 | ESPN2 | KFC Yum! Center · Louisville, KY |
| 16 | Wed Jan 8 | atWake Forest | W78-68 | 14-2 | .875 | #10 | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 17 | Wed Jan 15 | vsVirginia | W54-50 | 15-2 | .882 | #9 | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Sat Jan 18 | atMiami | W83-79 (OT) | 16-2 | .889 | #9 | ACC Network | Watsco Center · Coral Gables, FL |
| 19 | Sat Jan 25 | vsNotre Dame | W85-84 | 17-2 | .895 | #5 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 20 | Tue Jan 28 | atVirginia | L56-61 | 17-3 | .850 | #5 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 21 | Sat Feb 1 | atVirginia Tech | W74-63 | 18-3 | .857 | #5 | | Cassell Coliseum · Blacksburg, VA |
| 22 | Mon Feb 3 | vsUNC | W65-59 | 19-3 | .864 | #8 | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Sat Feb 8 | vsMiami | W99-81 | 20-3 | .870 | #8 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 24 | Mon Feb 10 | at7Duke | L65-70 | 20-4 | .833 | #8 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 15 | vsSyracuse | W80-77 | 21-4 | .840 | #8 | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Tue Feb 18 | vsPitt | W82-67 | 22-4 | .846 | #8 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 22 | atNC State | W67-61 | 23-4 | .852 | #8 | ACC Network | PNC Arena · Raleigh, NC |
| 28 | Mon Feb 24 | vs11Louisville | W82-67 | 24-4 | .857 | #6 | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Feb 29 | atClemson | L69-70 | 24-5 | .828 | #6 | | Littlejohn Coliseum · Clemson, SC |
| 30 | Wed Mar 4 | atNotre Dame | W73-71 | 25-5 | .833 | #7 | ESPN2 | Purcell Pavilion · South Bend, IN |
| 31 | Sat Mar 7 | vsBoston College | W80-62 | 26-5 | .839 | #7 | | Donald L. Tucker Center · Tallahassee, FL |
