| 1 | Fri Nov 27 | vs Gardner-Webb | PPD | 18-7 | .720 | #21 | | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Wed Dec 2 | vsNorth Florida | W86-58 | 1-0 | 1.000 | #22 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 3 | Wed Dec 9 | vsIndiana | W69-67 (OT) | 2-0 | 1.000 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 4 | Sat Dec 12 | vsFlorida | W83-71 | 3-0 | 1.000 | #20 | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Tue Dec 15 | vsGeorgia Tech | W74-61 | 4-0 | 1.000 | #15 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Sat Dec 19 | vsUCF | L74-86 | 4-1 | .800 | #15 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 7 | Mon Dec 21 | vsGardner-Webb | W72-59 | 5-1 | .833 | #21 | | Donald L. Tucker Center · Tallahassee, FL |
| 8 | Tue Dec 29 | atClemson | L67-77 | 5-2 | .714 | #18 | | Littlejohn Coliseum · Clemson, SC |
| 10 | Sat Jan 9 | atPitt | PPD | 18-7 | .720 | #25 | | Petersen Events Center · Pittsburgh, PA |
| 11 | Wed Jan 13 | vsNC State | W105-73 | 6-2 | .750 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Sat Jan 16 | vsUNC | W82-75 | 7-2 | .778 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Mon Jan 18 | atLouisville | W78-65 | 8-2 | .800 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 14 | Sat Jan 23 | vs20Clemson | W80-61 | 9-2 | .818 | - | ABC | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Wed Jan 27 | vsMiami | W81-59 | 10-2 | .833 | #16 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 30 | atGeorgia Tech | L65-76 | 10-3 | .769 | #16 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 19 | Sat Feb 13 | vsWake Forest | W92-85 (OT) | 11-3 | .786 | #17 | | Donald L. Tucker Center · Tallahassee, FL |
| 20 | Mon Feb 15 | vs7Virginia | W81-60 | 12-3 | .800 | #16 | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 21 | Sat Feb 20 | atPitt | W79-72 | 13-3 | .813 | #16 | | Petersen Events Center · Pittsburgh, PA |
| 22 | Wed Feb 24 | atMiami | W88-71 | 14-3 | .824 | #11 | ACC Network | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 27 | atUNC | L70-78 | 14-4 | .778 | #11 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Wed Mar 3 | vsBoston College | W93-64 | 15-4 | .789 | #11 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 25 | Sat Mar 6 | atNotre Dame | L73-83 | 15-5 | .750 | #11 | ESPN2 | Purcell Pavilion · South Bend, IN |
| 27 | Fri Mar 12 | vsUNC | W69-66 | 16-5 | .762 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 28 | Sat Mar 13 | vsGeorgia Tech | L75-80 | 16-6 | .727 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 25 | Sat Mar 20 | vs13UNC Greensboro | W64-54 | 17-6 | .739 | #4 | truTV | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Mon Mar 22 | vs5Colorado | W71-53 | 18-6 | .750 | #4 | TBS | Indiana Farmers Coliseum · Indianapolis, IN |
| 27 | Sun Mar 28 | at1Michigan | L58-76 | 18-7 | .720 | #4 | CBS | Crisler Center · Ann Arbor, MI |
