| 1 | Thu Nov 26 | at Gonzaga | L90-102 | 0-1 | .000 | - | FOX | McCarthey Athletic Center · Spokane, WA |
| 2 | Fri Nov 27 | vsSaint Joseph's | W94-72 | 1-1 | .500 | - | FS1 | Allen Fieldhouse · Lawrence, KS |
| 3 | Tue Dec 1 | atKentucky | W65-62 | 2-1 | .667 | - | ESPN | Rupp Arena · Lexington, KY |
| 4 | Thu Dec 3 | vsTBD | W89-54 | 3-1 | .750 | #7 | | Allen Fieldhouse · Lawrence, KS |
| 5 | Sat Dec 5 | vsN Dakota St | W65-61 | 4-1 | .800 | #7 | | Allen Fieldhouse · Lawrence, KS |
| 6 | Tue Dec 8 | vsCreighton | W73-72 | 5-1 | .833 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Fri Dec 11 | vsOmaha | W95-50 | 6-1 | .857 | #5 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Thu Dec 17 | at14Texas Tech | W58-57 | 7-1 | .875 | #5 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 10 | Tue Dec 22 | vs7West Virginia | W79-65 | 8-1 | .889 | #3 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Jan 2 | vs8Texas | L59-84 | 8-2 | .800 | #3 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 12 | Tue Jan 5 | atTCU | W93-64 | 9-2 | .818 | #6 | ESPN | Schollmaier Arena · Fort Worth, TX |
| 13 | Sat Jan 9 | vsOklahoma | W63-59 | 10-2 | .833 | #6 | CBS | Allen Fieldhouse · Lawrence, KS |
| 14 | Tue Jan 12 | atOklahoma St | L70-75 | 10-3 | .769 | #6 | | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 16 | vsIowa State | PPD | 21-9 | .700 | #6 | | Allen Fieldhouse · Lawrence, KS |
| 16 | Mon Jan 18 | at2Baylor | L69-77 | 10-4 | .714 | #9 | ESPN | Ferrell Center · Waco, TX |
| 17 | Sat Jan 23 | atOklahoma | L68-75 | 10-5 | .667 | #9 | ESPN | Lloyd Noble Center · Norman, OK |
| 18 | Thu Jan 28 | vsTCU | W59-51 | 11-5 | .688 | #15 | | Allen Fieldhouse · Lawrence, KS |
| 19 | Sat Jan 30 | atTennessee | L61-80 | 11-6 | .647 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 20 | Tue Feb 2 | vsKansas St | W74-51 | 12-6 | .667 | - | | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Feb 6 | atWest Virginia | L79-91 | 12-7 | .632 | - | CBS | WVU Coliseum · Morgantown, WV |
| 22 | Mon Feb 8 | vs23Oklahoma St | W78-66 | 13-7 | .650 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Thu Feb 11 | vsIowa State | W97-64 | 14-7 | .667 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Sat Feb 13 | atIowa State | W64-50 | 15-7 | .682 | - | | James H. Hilton Coliseum · Ames, IA |
| 25 | Wed Feb 17 | atKansas St | W59-41 | 16-7 | .696 | - | | Bramlage Coliseum · Manhattan, KS |
| 26 | Sat Feb 20 | vs15Texas Tech | W67-61 | 17-7 | .708 | #23 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 27 | Tue Feb 23 | at14Texas | L72-75 (OT) | 17-8 | .680 | #17 | ESPN | Moody Center · Austin, TX |
| 28 | Sat Feb 27 | vs2Baylor | W71-58 | 18-8 | .692 | #17 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Thu Mar 4 | vsUTEP | W67-62 | 19-8 | .704 | #13 | | Allen Fieldhouse · Lawrence, KS |
| 30 | Thu Mar 11 | vsOklahoma | W69-62 | 20-8 | .714 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 30 | Sat Mar 20 | vs14E Washington | W93-84 | 21-8 | .724 | #3 | TBS | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Mon Mar 22 | vs6USC | L51-85 | 21-9 | .700 | #3 | CBS | Hinkle Fieldhouse · Indianapolis, IN |
