| 1 | Tue Nov 5 | at Duke | L66-68 | 0-1 | .000 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 8 | vs UNC Greensboro | W74-62 | 1-1 | .500 | #3 | ESPNU | Allen Fieldhouse · Lawrence, KS |
| 3 | Fri Nov 15 | vs Monmouth | W112-57 | 2-1 | .667 | #5 | | Allen Fieldhouse · Lawrence, KS |
| 4 | Tue Nov 19 | vs ETSU | W75-63 | 3-1 | .750 | - | | Allen Fieldhouse · Lawrence, KS |
| 5 | Mon Nov 25 | at TBD | W93-63 | 4-1 | .800 | - | ESPNU | Lahaina Civic Center |
| 6 | Tue Nov 26 | at BYU | W71-56 | 5-1 | .833 | - | ESPN | Marriott Center · Provo, UT |
| 7 | Wed Nov 27 | vs Dayton | W90-84 (OT) | 6-1 | .857 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 8 | Sat Dec 7 | vs #20Colorado | W72-58 | 7-1 | .875 | #2 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Tue Dec 10 | vs Milwaukee | W95-68 | 8-1 | .889 | #2 | | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 14 | vs Kansas City | W98-57 | 9-1 | .900 | #2 | | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Dec 21 | at #18Villanova | L55-56 | 9-2 | .818 | #1 | FOX | Finneran Pavilion · Villanova, PA |
| 12 | Sun Dec 29 | at Stanford | W72-56 | 10-2 | .833 | #5 | ABC | Maples Pavilion · Stanford, CA |
| 13 | Sat Jan 4 | vs #16West Virginia | W60-53 | 11-2 | .846 | #3 | | Allen Fieldhouse · Lawrence, KS |
| 14 | Wed Jan 8 | at Iowa State | W79-53 | 12-2 | .857 | #3 | | James H. Hilton Coliseum · Ames, IA |
| 15 | Sat Jan 11 | vs #4Baylor | L55-67 | 12-3 | .800 | #3 | CBS | Allen Fieldhouse · Lawrence, KS |
| 16 | Tue Jan 14 | at Oklahoma | W66-52 | 13-3 | .813 | #6 | ESPN | Lloyd Noble Center · Norman, OK |
| 17 | Sat Jan 18 | at Texas | W66-57 | 14-3 | .824 | #6 | ESPN | Moody Center · Austin, TX |
| 18 | Tue Jan 21 | vs Kansas St | W81-60 | 15-3 | .833 | #3 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 19 | Sat Jan 25 | vs Tennessee | W74-68 | 16-3 | .842 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 20 | Mon Jan 27 | at Oklahoma St | W65-50 | 17-3 | .850 | #3 | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 21 | Sat Feb 1 | vs Texas Tech | W78-75 | 18-3 | .857 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Mon Feb 3 | vsTexas | W69-58 | 19-3 | .864 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Sat Feb 8 | at TCU | W60-46 | 20-3 | .870 | #3 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 24 | Wed Feb 12 | at#14West Virginia | W58-49 | 21-3 | .875 | #3 | | WVU Coliseum · Morgantown, WV |
| 25 | Sat Feb 15 | vsOklahoma | W87-70 | 22-3 | .880 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 26 | Mon Feb 17 | vsIowa State | W91-71 | 23-3 | .885 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 27 | Sat Feb 22 | at#1Baylor | W64-61 | 24-3 | .889 | #3 | ESPN | Ferrell Center · Waco, TX |
| 28 | Mon Feb 24 | vsOklahoma St | W83-58 | 25-3 | .893 | #1 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Feb 29 | atKansas St | W62-58 | 26-3 | .897 | #1 | CBS | Bramlage Coliseum · Manhattan, KS |
| 30 | Wed Mar 4 | vsTCU | W75-66 | 27-3 | .900 | #1 | | Allen Fieldhouse · Lawrence, KS |
| 31 | Sat Mar 7 | atTexas Tech | W66-62 | 28-3 | .903 | #1 | ESPN | United Supermarkets Arena · Lubbock, TX |
