| 1 | Mon Nov 7 | vs Omaha | W89-64 | 1-0 | 1.000 | #5 | | Allen Fieldhouse · Lawrence, KS |
| 2 | Thu Nov 10 | vs N Dakota St | W82-59 | 2-0 | 1.000 | #5 | | Allen Fieldhouse · Lawrence, KS |
| 3 | Tue Nov 15 | vs Duke | W69-64 | 3-0 | 1.000 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 4 | Fri Nov 18 | vs Southern Utah | W82-76 | 4-0 | 1.000 | #6 | | Allen Fieldhouse · Lawrence, KS |
| 5 | Wed Nov 23 | vs NC State | W80-74 | 5-0 | 1.000 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 6 | Thu Nov 24 | vs Wisconsin | W69-68 (OT) | 6-0 | 1.000 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Fri Nov 25 | vs Tennessee | L50-64 | 6-1 | .857 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 8 | Mon Nov 28 | vs Texas So | W87-55 | 7-1 | .875 | #9 | | Allen Fieldhouse · Lawrence, KS |
| 9 | Thu Dec 1 | vs Seton Hall | W91-65 | 8-1 | .889 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 10 | at Missouri | W95-67 | 9-1 | .900 | #6 | ESPN | Mizzou Arena · Columbia, MO |
| 11 | Sat Dec 17 | vs #14Indiana | W84-62 | 10-1 | .909 | #8 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 12 | Thu Dec 22 | vs Harvard | W68-54 | 11-1 | .917 | #4 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Dec 31 | vs Oklahoma St | W69-67 | 12-1 | .923 | #4 | CBS | Allen Fieldhouse · Lawrence, KS |
| 14 | Tue Jan 3 | at Texas Tech | W75-72 | 13-1 | .929 | #3 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 15 | Sat Jan 7 | at West Virginia | W76-62 | 14-1 | .933 | #3 | | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 10 | vs Oklahoma | W79-75 | 15-1 | .938 | #2 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 17 | Sat Jan 14 | vs #14Iowa State | W62-60 | 16-1 | .941 | #2 | | Allen Fieldhouse · Lawrence, KS |
| 18 | Tue Jan 17 | at #13Kansas St | L82-83 (OT) | 16-2 | .889 | #2 | ESPN | Bramlage Coliseum · Manhattan, KS |
| 19 | Sat Jan 21 | vs #14TCU | L60-83 | 16-3 | .842 | #2 | CBS | Allen Fieldhouse · Lawrence, KS |
| 20 | Mon Jan 23 | at #17Baylor | L69-75 | 16-4 | .800 | #9 | ESPN | Ferrell Center · Waco, TX |
| 21 | Sat Jan 28 | at Kentucky | W77-68 | 17-4 | .810 | - | ESPN | Rupp Arena · Lexington, KY |
| 22 | Tue Jan 31 | vs#7Kansas St | W90-78 | 18-4 | .818 | #8 | | Allen Fieldhouse · Lawrence, KS |
| 23 | Sat Feb 4 | at#13Iowa State | L53-68 | 18-5 | .783 | #8 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 24 | Mon Feb 6 | vs #5Texas | W88-80 | 19-5 | .792 | #9 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 11 | atOklahoma | W78-55 | 20-5 | .800 | #9 | CBS | Lloyd Noble Center · Norman, OK |
| 26 | Tue Feb 14 | atOklahoma St | W87-76 | 21-5 | .808 | #5 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sat Feb 18 | vs#9Baylor | W87-71 | 22-5 | .815 | #5 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Mon Feb 20 | at#24TCU | W63-58 | 23-5 | .821 | #3 | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 29 | Sat Feb 25 | vsWest Virginia | W76-74 | 24-5 | .828 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 30 | Tue Feb 28 | vsTexas Tech | W67-63 | 25-5 | .833 | #3 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 31 | Sat Mar 4 | at#9Texas | L59-75 | 25-6 | .806 | #3 | ESPN | Moody Center · Austin, TX |
| 32 | Thu Mar 9 | vsWest Virginia | W78-61 | 26-6 | .813 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 33 | Fri Mar 10 | vsIowa State | W71-58 | 27-6 | .818 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 34 | Sat Mar 11 | vsTexas | L56-76 | 27-7 | .794 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 35 | Thu Mar 16 | vs #16Howard | W96-68 | 28-7 | .800 | #1 | TBS | Allen Fieldhouse · Lawrence, KS |
| 36 | Sat Mar 18 | vs #8Arkansas | L71-72 | 28-8 | .778 | #1 | CBS | Allen Fieldhouse · Lawrence, KS |
