| 1 | Tue Nov 9 | at Michigan St | W87-74 | 1-0 | 1.000 | - | ESPN | Breslin Center · East Lansing, MI |
| 2 | Fri Nov 12 | vsTarleton | W88-62 | 2-0 | 1.000 | #3 | | Allen Fieldhouse · Lawrence, KS |
| 3 | Thu Nov 18 | vsStony Brook | W88-59 | 3-0 | 1.000 | #3 | | Allen Fieldhouse · Lawrence, KS |
| 4 | Thu Nov 25 | vsNorth Texas | W71-59 | 4-0 | 1.000 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 5 | Fri Nov 26 | vsDayton | L73-74 | 4-1 | .800 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 6 | Sun Nov 28 | atIona | W96-83 | 5-1 | .833 | - | ESPN | Hynes Athletics Center · New Rochelle, NY |
| 7 | Fri Dec 3 | atSt John's | W95-75 | 6-1 | .857 | - | FS1 | Carnesecca Arena · Queens, NY |
| 8 | Tue Dec 7 | vsUTEP | W78-52 | 7-1 | .875 | #8 | | T-Mobile Center · Kansas City, MOS |
| 9 | Sat Dec 11 | vsMissouri | W102-65 | 8-1 | .889 | #8 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 18 | vsSF Austin | W80-72 | 9-1 | .900 | #7 | | Allen Fieldhouse · Lawrence, KS |
| 12 | Wed Dec 29 | vsNevada | W88-61 | 10-1 | .909 | #6 | | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Jan 1 | vsGeorge Mason | W76-67 | 11-1 | .917 | #6 | | Allen Fieldhouse · Lawrence, KS |
| 14 | Tue Jan 4 | atOklahoma St | W74-63 | 12-1 | .923 | #6 | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 8 | atTexas Tech | L67-75 | 12-2 | .857 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 16 | Tue Jan 11 | vs15Iowa State | W62-61 | 13-2 | .867 | #9 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Sat Jan 15 | vsWest Virginia | W85-59 | 14-2 | .875 | #9 | CBS | Allen Fieldhouse · Lawrence, KS |
| 18 | Tue Jan 18 | atOklahoma | W67-64 | 15-2 | .882 | #7 | ESPN | Lloyd Noble Center · Norman, OK |
| 19 | Sat Jan 22 | atKansas St | W78-75 | 16-2 | .889 | #7 | | Bramlage Coliseum · Manhattan, KS |
| 20 | Mon Jan 24 | vs13Texas Tech | W94-91 (2OT) | 17-2 | .895 | #5 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Jan 29 | vsKentucky | L62-80 | 17-3 | .850 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Tue Feb 1 | at20Iowa State | W70-61 | 18-3 | .857 | #10 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 23 | Sat Feb 5 | vs8Baylor | W83-59 | 19-3 | .864 | #10 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Mon Feb 7 | at20Texas | L76-79 | 19-4 | .826 | #8 | ESPN | Moody Center · Austin, TX |
| 25 | Sat Feb 12 | vsOklahoma | W71-69 | 20-4 | .833 | #8 | CBS | Allen Fieldhouse · Lawrence, KS |
| 26 | Mon Feb 14 | vsOklahoma St | W76-62 | 21-4 | .840 | #6 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 27 | Sat Feb 19 | atWest Virginia | W71-58 | 22-4 | .846 | #6 | ESPN | WVU Coliseum · Morgantown, WV |
| 28 | Tue Feb 22 | vsKansas St | W102-83 | 23-4 | .852 | #5 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Feb 26 | at10Baylor | L70-80 | 23-5 | .821 | #5 | ESPN | Ferrell Center · Waco, TX |
| 30 | Tue Mar 1 | atTCU | L64-74 | 23-6 | .793 | #6 | | Schollmaier Arena · Fort Worth, TX |
| 31 | Thu Mar 3 | vsTCU | W72-68 | 24-6 | .800 | #6 | | Allen Fieldhouse · Lawrence, KS |
| 32 | Sat Mar 5 | vs21Texas | W70-63 (OT) | 25-6 | .806 | #6 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 33 | Thu Mar 10 | vsWest Virginia | W87-63 | 26-6 | .813 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 34 | Fri Mar 11 | vsTCU | W75-62 | 27-6 | .818 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 35 | Sat Mar 12 | vsTexas Tech | W74-65 | 28-6 | .824 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 35 | Thu Mar 17 | vs16Texas So | W83-56 | 29-6 | .829 | #1 | truTV | Allen Fieldhouse · Lawrence, KS |
| 36 | Sat Mar 19 | vs9Creighton | W79-72 | 30-6 | .833 | #1 | CBS | Allen Fieldhouse · Lawrence, KS |
| 37 | Fri Mar 25 | vs4Providence | W66-61 | 31-6 | .838 | #1 | TBS | Allen Fieldhouse · Lawrence, KS |
| 38 | Sun Mar 27 | vs10Miami | W76-50 | 32-6 | .842 | #1 | CBS | Allen Fieldhouse · Lawrence, KS |
| 39 | Sat Apr 2 | vs2Villanova | W81-65 | 33-6 | .846 | #1 | TBS | Caesars Superdome · New Orleans, LA |
| 40 | Mon Apr 4 | vs8UNC | W72-69 | 34-6 | .850 | #1 | TBS | Caesars Superdome · New Orleans, LA |
