| 1 | Mon Nov 6 | vs NC Central | W99-56 | 1-0 | 1.000 | #1 | | Allen Fieldhouse · Lawrence, KS |
| 2 | Fri Nov 10 | vs Manhattan | W99-61 | 2-0 | 1.000 | #1 | | Allen Fieldhouse · Lawrence, KS |
| 3 | Tue Nov 14 | vs #17Kentucky | W89-84 | 3-0 | 1.000 | #1 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 4 | Mon Nov 20 | at TBD | W83-56 | 4-0 | 1.000 | #1 | ESPNU | Stan Sheriff Center |
| 5 | Tue Nov 21 | at #4Marquette | L59-73 | 4-1 | .800 | #1 | ESPN | Fiserv Forum · Milwaukee, WI |
| 6 | Wed Nov 22 | vs #7Tennessee | W69-60 | 5-1 | .833 | #1 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 28 | vs E Illinois | W71-63 | 6-1 | .857 | #5 | | Allen Fieldhouse · Lawrence, KS |
| 8 | Fri Dec 1 | vs #4UConn | W69-65 | 7-1 | .875 | #5 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Tue Dec 5 | vs Kansas City | W88-69 | 8-1 | .889 | #2 | | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 9 | vs Missouri | W73-64 | 9-1 | .900 | #2 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Dec 16 | at Indiana | W75-71 | 10-1 | .909 | #2 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 12 | Fri Dec 22 | vs Yale | W75-60 | 11-1 | .917 | #2 | | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Dec 30 | vs Wichita St | W86-67 | 12-1 | .923 | #2 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 14 | Sat Jan 6 | vs TCU | W83-81 | 13-1 | .929 | #2 | CBS | Allen Fieldhouse · Lawrence, KS |
| 15 | Wed Jan 10 | at UCF | L60-65 | 13-2 | .867 | #3 | | Addition Financial Arena · Orlando, FL |
| 16 | Sat Jan 13 | vs #9Oklahoma | W78-66 | 14-2 | .875 | #3 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Tue Jan 16 | at Oklahoma St | W90-66 | 15-2 | .882 | #3 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Sat Jan 20 | at West Virginia | L85-91 | 15-3 | .833 | #3 | | WVU Coliseum · Morgantown, WV |
| 19 | Mon Jan 22 | vs Cincinnati | W74-69 | 16-3 | .842 | #7 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 20 | Sat Jan 27 | at #23Iowa State | L75-79 | 16-4 | .800 | #7 | CBS | James H. Hilton Coliseum · Ames, IA |
| 21 | Tue Jan 30 | vsOklahoma St | W83-54 | 17-4 | .810 | #8 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Sat Feb 3 | vs #4Houston | W78-65 | 18-4 | .818 | #8 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Mon Feb 5 | at Kansas St | L70-75 (OT) | 18-5 | .783 | #4 | ESPN | Bramlage Coliseum · Manhattan, KS |
| 24 | Sat Feb 10 | vs #13Baylor | W64-61 | 19-5 | .792 | #4 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 25 | Mon Feb 12 | at Texas Tech | L50-79 | 19-6 | .760 | #6 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 26 | Sat Feb 17 | at#25Oklahoma | W67-57 | 20-6 | .769 | #6 | ESPN | Lloyd Noble Center · Norman, OK |
| 27 | Sat Feb 24 | vs Texas | W86-67 | 21-6 | .778 | #9 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 27 | vs BYU | L68-76 | 21-7 | .750 | #7 | | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Mar 2 | at#15Baylor | L74-82 | 21-8 | .724 | #7 | ABC | Ferrell Center · Waco, TX |
| 30 | Tue Mar 5 | vsKansas St | W90-68 | 22-8 | .733 | #14 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 31 | Sat Mar 9 | at#1Houston | L46-76 | 22-9 | .710 | #14 | ESPN | Fertitta Center · Houston, TX |
| 32 | Wed Mar 13 | vsCincinnati | L52-72 | 22-10 | .688 | #16 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 33 | Thu Mar 21 | vs #13Samford | W93-89 | 23-10 | .697 | #4 | TBS | Allen Fieldhouse · Lawrence, KS |
| 34 | Sat Mar 23 | vs #5Gonzaga | L68-89 | 23-11 | .676 | #4 | CBS | Allen Fieldhouse · Lawrence, KS |
