| 1 | Mon Nov 3 | vs Green Bay | 8:00 PM | 4-28 | .125 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 2 | Fri Nov 7 | at#25UNC | 7:00 PM | 23-14 | .622 | #19 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 3 | Tue Nov 11 | vsTexas A&M-CC | 8:00 PM | 20-14 | .588 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 4 | Sat Nov 15 | vsPrinceton | 2:00 PM | 19-11 | .633 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Tue Nov 18 | at#6Duke | 9:00 PM | 35-4 | .897 | #19 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Mon Nov 24 | vsNotre Dame | 3:30 PM | 15-18 | .455 | #19 | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 25 | vsSyracuse | 3:30 PM | 14-19 | .424 | #19 | TNT | Allen Fieldhouse · Lawrence, KS |
| 8 | Tue Dec 2 | vs#4UConn | 9:00 PM | 24-11 | .686 | #19 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Sun Dec 7 | vsMissouri | 1:00 PM | 22-12 | .647 | #19 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 13 | atNC State | 5:30 PM | 12-19 | .387 | #19 | ESPN | PNC Arena · Raleigh, NC |
| 11 | Tue Dec 16 | vsTowson | 9:00 PM | 22-11 | .667 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 12 | Mon Dec 22 | vsDavidson | 8:00 PM | 17-16 | .515 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Jan 3 | atUCF | 2:00 PM | 20-17 | .541 | #19 | Peacock | Addition Financial Arena · Orlando, FL |
| 14 | Tue Jan 6 | vsTCU | 9:00 PM | 16-16 | .500 | #19 | | Allen Fieldhouse · Lawrence, KS |
| 15 | Sat Jan 10 | atWest Virginia | 12:00 PM | 19-13 | .594 | #19 | | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 13 | vs#16Iowa State | 9:00 PM | 25-10 | .714 | #19 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Fri Jan 16 | vsBaylor | 8:00 PM | 20-15 | .571 | #19 | FOX | Allen Fieldhouse · Lawrence, KS |
| 18 | Sun Jan 18 | atColorado | 11:00 PM | 14-21 | .400 | #19 | ESPN | CU Events Center · Boulder, CO |
| 19 | Sat Jan 24 | atKansas St | 8:00 PM | 16-17 | .485 | #19 | FOX | Bramlage Coliseum · Manhattan, KS |
| 20 | Sat Jan 31 | vs#8BYU | TBD | 26-10 | .722 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 21 | Mon Feb 2 | at#10Texas Tech | 9:00 PM | 28-9 | .757 | #19 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 22 | Sat Feb 7 | vsUtah | 2:30 PM | 16-17 | .485 | #19 | FOX | Allen Fieldhouse · Lawrence, KS |
| 23 | Mon Feb 9 | vs#13Arizona | 9:00 PM | 24-13 | .649 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Sat Feb 14 | at#16Iowa State | 1:00 PM | 25-10 | .714 | #19 | ABC | James H. Hilton Coliseum · Ames, IA |
| 25 | Wed Feb 18 | atOklahoma St | 9:00 PM | 17-18 | .486 | #19 | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Sat Feb 21 | vsCincinnati | 1:00 PM | 19-16 | .543 | #19 | CBS | Allen Fieldhouse · Lawrence, KS |
| 27 | Mon Feb 23 | vs#2Houston | 9:00 PM | 35-5 | .875 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Sat Feb 28 | at#13Arizona | TBD | 24-13 | .649 | #19 | ESPN | McKale Center · Tucson, AZ |
| 29 | Tue Mar 3 | atArizona St | 9:00 PM | 13-20 | .394 | #19 | FS1 | Desert Financial Arena · Tempe, AZ |
| 30 | Sat Mar 7 | vsKansas St | 2:00 PM | 16-17 | .485 | #19 | CBS | Allen Fieldhouse · Lawrence, KS |
