| 1 | Mon Nov 3 | vs Green Bay | W94-51 | 1-0 | 1.000 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 2 | Fri Nov 7 | at25UNC | L74-87 | 1-1 | .500 | #19 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 3 | Tue Nov 11 | vsTexas A&M-CC | W77-46 | 2-1 | .667 | #25 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 4 | Sat Nov 15 | vsPrinceton | W76-57 | 3-1 | .750 | #25 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Tue Nov 18 | at5Duke | L66-78 | 3-2 | .600 | #24 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Mon Nov 24 | vsNotre Dame | W71-61 | 4-2 | .667 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 25 | vsSyracuse | W71-60 | 5-2 | .714 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 8 | Wed Nov 26 | at17Tennessee | W81-76 | 6-2 | .750 | - | TNT | Thompson-Boling Arena · Knoxville, TN |
| 9 | Tue Dec 2 | vs5UConn | L56-61 | 6-3 | .667 | #21 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 10 | Sun Dec 7 | vsMissouri | W80-60 | 7-3 | .700 | #21 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Dec 13 | atNC State | W77-76 (OT) | 8-3 | .727 | #19 | ESPN | PNC Arena · Raleigh, NC |
| 12 | Tue Dec 16 | vsTowson | W73-49 | 9-3 | .750 | #17 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 13 | Mon Dec 22 | vsDavidson | W90-61 | 10-3 | .769 | #17 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 14 | Sat Jan 3 | atUCF | L75-81 | 10-4 | .714 | #17 | Peacock | Addition Financial Arena · Orlando, FL |
| 15 | Tue Jan 6 | vsTCU | W104-100 (OT) | 11-4 | .733 | #22 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 16 | Sat Jan 10 | atWest Virginia | L75-86 | 11-5 | .688 | #22 | FOX | WVU Coliseum · Morgantown, WV |
| 17 | Tue Jan 13 | vs2Iowa State | W84-63 | 12-5 | .706 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 18 | Fri Jan 16 | vsBaylor | W80-62 | 13-5 | .722 | - | FOX | Allen Fieldhouse · Lawrence, KS |
| 19 | Tue Jan 20 | atColorado | W75-69 | 14-5 | .737 | #19 | ESPN | CU Events Center · Boulder, CO |
| 20 | Sat Jan 24 | atKansas St | W86-62 | 15-5 | .750 | #19 | FOX | Bramlage Coliseum · Manhattan, KS |
| 21 | Sat Jan 31 | vs13BYU | W90-82 | 16-5 | .762 | #14 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Mon Feb 2 | at13Texas Tech | W64-61 | 17-5 | .773 | #11 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 7 | vsUtah | W71-59 | 18-5 | .783 | #11 | FOX | Allen Fieldhouse · Lawrence, KS |
| 24 | Mon Feb 9 | vs1Arizona | W82-78 | 19-5 | .792 | #9 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 14 | at5Iowa State | L56-74 | 19-6 | .760 | #9 | ABC | James H. Hilton Coliseum · Ames, IA |
| 26 | Wed Feb 18 | atOklahoma St | W81-69 | 20-6 | .769 | #8 | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sat Feb 21 | vsCincinnati | L68-84 | 20-7 | .741 | #8 | CBS | Allen Fieldhouse · Lawrence, KS |
| 28 | Mon Feb 23 | vs5Houston | W69-56 | 21-7 | .750 | #14 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Feb 28 | at2Arizona | L61-84 | 21-8 | .724 | #14 | ESPN | McKale Center · Tucson, AZ |
