| 3 | Tue Nov 11 | vs Texas A&M-CC | 8:00 PM | 1-2 | .333 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 4 | Sat Nov 15 | vsPrinceton | 2:00 PM | 0-1 | .000 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Tue Nov 18 | at#6Duke | 9:00 PM | 2-0 | 1.000 | #19 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Mon Nov 24 | vsNotre Dame | 3:30 PM | 2-0 | 1.000 | #19 | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 25 | vsSyracuse | 3:30 PM | 2-0 | 1.000 | #19 | TNT | Allen Fieldhouse · Lawrence, KS |
| 8 | Tue Dec 2 | vs#4UConn | 9:00 PM | 2-0 | 1.000 | #19 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Sun Dec 7 | vsMissouri | 1:00 PM | 2-0 | 1.000 | #19 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 10 | Sat Dec 13 | atNC State | 5:30 PM | 2-0 | 1.000 | #19 | ESPN | PNC Arena · Raleigh, NC |
| 11 | Tue Dec 16 | vsTowson | 9:00 PM | 1-1 | .500 | #19 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 12 | Mon Dec 22 | vsDavidson | 8:00 PM | 2-0 | 1.000 | #19 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Jan 3 | atUCF | 2:00 PM | 1-1 | .500 | #19 | Peacock | Addition Financial Arena · Orlando, FL |
| 14 | Tue Jan 6 | vsTCU | 9:00 PM | 1-1 | .500 | #19 | | Allen Fieldhouse · Lawrence, KS |
| 15 | Sat Jan 10 | atWest Virginia | 12:00 PM | 2-0 | 1.000 | #19 | | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 13 | vs#16Iowa State | 9:00 PM | 2-0 | 1.000 | #19 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Fri Jan 16 | vsBaylor | 8:00 PM | 1-0 | 1.000 | #19 | FOX | Allen Fieldhouse · Lawrence, KS |
| 18 | Tue Jan 20 | atColorado | 11:00 PM | 2-0 | 1.000 | #19 | ESPN | CU Events Center · Boulder, CO |
| 19 | Sat Jan 24 | atKansas St | 8:00 PM | 2-0 | 1.000 | #19 | FOX | Bramlage Coliseum · Manhattan, KS |
| 20 | Sat Jan 31 | vs#8BYU | 4:00 PM | 2-0 | 1.000 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 21 | Mon Feb 2 | at#10Texas Tech | 9:00 PM | 2-0 | 1.000 | #19 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 22 | Sat Feb 7 | vsUtah | 2:30 PM | 2-0 | 1.000 | #19 | FOX | Allen Fieldhouse · Lawrence, KS |
| 23 | Mon Feb 9 | vs#13Arizona | 9:00 PM | 2-0 | 1.000 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 24 | Sat Feb 14 | at#16Iowa State | 1:00 PM | 2-0 | 1.000 | #19 | ABC | James H. Hilton Coliseum · Ames, IA |
| 25 | Wed Feb 18 | atOklahoma St | 9:00 PM | 1-0 | 1.000 | #19 | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Sat Feb 21 | vsCincinnati | 1:00 PM | 2-0 | 1.000 | #19 | CBS | Allen Fieldhouse · Lawrence, KS |
| 27 | Mon Feb 23 | vs#2Houston | 9:00 PM | 2-0 | 1.000 | #19 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Sat Feb 28 | at#13Arizona | 4:00 PM | 2-0 | 1.000 | #19 | ESPN | McKale Center · Tucson, AZ |
| 29 | Tue Mar 3 | atArizona St | 9:00 PM | 1-0 | 1.000 | #19 | FS1 | Desert Financial Arena · Tempe, AZ |
| 30 | Sat Mar 7 | vsKansas St | 2:00 PM | 2-0 | 1.000 | #19 | CBS | Allen Fieldhouse · Lawrence, KS |
