| 1 | Mon Nov 4 | vs Howard | W87-57 | 1-0 | 1.000 | #1 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 2 | Fri Nov 8 | vs9UNC | W92-89 | 2-0 | 1.000 | #1 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 3 | Tue Nov 12 | vsMichigan St | W77-69 | 3-0 | 1.000 | #1 | ESPN | State Farm Arena · Atlanta, GA |
| 4 | Sat Nov 16 | vsOakland | W78-57 | 4-0 | 1.000 | #1 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Tue Nov 19 | vsUNC Wilmington | W84-66 | 5-0 | 1.000 | #1 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 6 | Tue Nov 26 | at11Duke | W75-72 | 6-0 | 1.000 | #1 | ESPN | T-Mobile Arena · Las Vegas, NV |
| 7 | Sat Nov 30 | vsFurman | W86-51 | 7-0 | 1.000 | #1 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 8 | Wed Dec 4 | atCreighton | L63-76 | 7-1 | .875 | #1 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 9 | Sun Dec 8 | atMissouri | L67-76 | 7-2 | .778 | #1 | ESPN2 | Mizzou Arena · Columbia, MO |
| 10 | Sat Dec 14 | vsNC State | W75-60 | 8-2 | .800 | #10 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 11 | Sun Dec 22 | vsBrown | W87-53 | 9-2 | .818 | #8 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 12 | Tue Dec 31 | vsWest Virginia | L61-62 | 9-3 | .750 | #7 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 13 | Sun Jan 5 | atUCF | W99-48 | 10-3 | .769 | #7 | ESPN+ | Addition Financial Arena · Orlando, FL |
| 14 | Wed Jan 8 | vsArizona St | W74-55 | 11-3 | .786 | #11 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 15 | Sat Jan 11 | atCincinnati | W54-40 | 12-3 | .800 | #11 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 16 | Wed Jan 15 | at2Iowa State | L57-74 | 12-4 | .750 | #9 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 17 | Sat Jan 18 | vsKansas St | W84-74 | 13-4 | .765 | #9 | CBS | Allen Fieldhouse · Lawrence, KS |
| 18 | Wed Jan 22 | atTCU | W74-61 | 14-4 | .778 | #12 | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 19 | Sat Jan 25 | vs7Houston | L86-92 (2OT) | 14-5 | .737 | #12 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 20 | Tue Jan 28 | vsUCF | W91-87 | 15-5 | .750 | #11 | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Feb 1 | atBaylor | L70-81 | 15-6 | .714 | #11 | ESPN | Ferrell Center · Waco, TX |
| 22 | Mon Feb 3 | vs8Iowa State | W69-52 | 16-6 | .727 | #16 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Sat Feb 8 | atKansas St | L73-81 | 16-7 | .696 | #16 | ESPN | Bramlage Coliseum · Manhattan, KS |
| 24 | Tue Feb 11 | vsColorado | W71-59 | 17-7 | .708 | #17 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 15 | atUtah | L67-74 | 17-8 | .680 | #17 | ESPN | Jon M. Huntsman Center · Salt Lake City, UT |
| 26 | Tue Feb 18 | atBYU | L57-91 | 17-9 | .654 | #23 | ESPN | Marriott Center · Provo, UT |
| 27 | Sat Feb 22 | vsOklahoma St | W96-64 | 18-9 | .667 | #23 | CBS | Allen Fieldhouse · Lawrence, KS |
| 28 | Mon Feb 24 | atColorado | W71-64 | 19-9 | .679 | - | ESPN | CU Events Center · Boulder, CO |
| 29 | Sat Mar 1 | vs10Texas Tech | L73-78 | 19-10 | .655 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 30 | Mon Mar 3 | at3Houston | L59-65 | 19-11 | .633 | - | ESPN | Fertitta Center · Houston, TX |
| 31 | Sat Mar 8 | vs24Arizona | W83-76 | 20-11 | .645 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 32 | Wed Mar 12 | vsUCF | W98-94 (OT) | 21-11 | .656 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 33 | Thu Mar 13 | atArizona | L77-88 | 21-12 | .636 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 34 | Thu Mar 20 | vs10Arkansas | L72-79 | 21-13 | .618 | #7 | CBS | Amica Mutual Pavilion · Providence, RI |
