| 1 | Mon Nov 7 | vs W Michigan | W61-60 | 1-0 | 1.000 | - | | Williams Arena · Minneapolis, MN |
| 2 | Fri Nov 11 | vsSt Francis BK | W72-54 | 2-0 | 1.000 | - | | Williams Arena · Minneapolis, MN |
| 3 | Mon Nov 14 | vsDePaul | L53-69 | 2-1 | .667 | - | BTN | Williams Arena · Minneapolis, MN |
| 4 | Thu Nov 17 | vsC Michigan | W68-60 | 3-1 | .750 | - | BTN | Williams Arena · Minneapolis, MN |
| 5 | Mon Nov 21 | vsCA Baptist | W62-61 (OT) | 4-1 | .800 | - | CBS | Williams Arena · Minneapolis, MN |
| 6 | Wed Nov 23 | atUNLV | L62-71 | 4-2 | .667 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 7 | Mon Nov 28 | atVirginia Tech | L57-67 | 4-3 | .571 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 8 | Sun Dec 4 | at#5Purdue | L70-89 | 4-4 | .500 | - | BTN | Mackey Arena · West Lafayette, IN |
| 9 | Thu Dec 8 | vsMichigan | L75-90 | 4-5 | .444 | - | BTN | Williams Arena · Minneapolis, MN |
| 10 | Sun Dec 11 | vs#23Mississippi St | L51-69 | 4-6 | .400 | - | BTN | Williams Arena · Minneapolis, MN |
| 11 | Wed Dec 14 | vsAR-Pine Bluff | W72-56 | 5-6 | .455 | - | BTN | Williams Arena · Minneapolis, MN |
| 12 | Thu Dec 22 | vsChicago St | W58-55 | 6-6 | .500 | - | | Williams Arena · Minneapolis, MN |
| 14 | Tue Jan 3 | at#14Wisconsin | L60-63 | 6-7 | .462 | - | BTN | Kohl Center · Madison, WI |
| 15 | Sat Jan 7 | vsNebraska | L79-81 (OT) | 6-8 | .429 | - | BTN | Williams Arena · Minneapolis, MN |
| 16 | Thu Jan 12 | atOhio State | W70-67 | 7-8 | .467 | - | FS1 | Value City Arena · Columbus, OH |
| 17 | Mon Jan 16 | vsIllinois | L60-78 | 7-9 | .438 | - | BTN | Williams Arena · Minneapolis, MN |
| 18 | Thu Jan 19 | vs#3Purdue | L39-61 | 7-10 | .412 | - | ESPN2 | Williams Arena · Minneapolis, MN |
| 19 | Sun Jan 22 | atMichigan | L56-60 | 7-11 | .389 | - | BTN | Crisler Center · Ann Arbor, MI |
| 20 | Wed Jan 25 | vsIndiana | L57-61 | 7-12 | .368 | - | BTN | Williams Arena · Minneapolis, MN |
| 21 | Sat Jan 28 | atNorthwestern | L61-81 | 7-13 | .350 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 22 | Wed Feb 1 | atRutgers | L55-90 | 7-14 | .333 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 23 | Sat Feb 4 | vsMaryland | L46-81 | 7-15 | .318 | - | BTN | Williams Arena · Minneapolis, MN |
| 24 | Tue Feb 7 | atIllinois | PPD | 9-22 | .290 | - | | State Farm Center · Champaign, IL |
| 25 | Sun Feb 12 | vsIowa | L56-68 | 7-16 | .304 | - | FS1 | Williams Arena · Minneapolis, MN |
| 27 | Sat Feb 18 | vsPenn State | L69-76 | 7-17 | .292 | - | BTN | Williams Arena · Minneapolis, MN |
| 28 | Mon Feb 20 | atIllinois | L69-78 | 7-18 | .280 | - | BTN | State Farm Center · Champaign, IL |
| 29 | Wed Feb 22 | atMaryland | L70-88 | 7-19 | .269 | - | BTN | XFINITY Center · College Park, MD |
| 30 | Sat Feb 25 | atNebraska | L67-78 | 7-20 | .259 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 31 | Thu Mar 2 | vsRutgers | W75-74 | 8-20 | .286 | - | FS1 | Williams Arena · Minneapolis, MN |
| 32 | Sun Mar 5 | vsWisconsin | L67-71 | 8-21 | .276 | - | FS1 | Williams Arena · Minneapolis, MN |
| 33 | Wed Mar 8 | atNebraska | W78-75 | 9-21 | .300 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 34 | Thu Mar 9 | atMaryland | L54-70 | 9-22 | .290 | - | BTN | XFINITY Center · College Park, MD |
