| 1 | Tue Nov 9 | vs Kansas City | W71-56 | 1-0 | 1.000 | - | | Williams Arena · Minneapolis, MN |
| 2 | Fri Nov 12 | vsWestern KY | W73-69 | 2-0 | 1.000 | - | ESPNEWS | Williams Arena · Minneapolis, MN |
| 3 | Sun Nov 14 | atPrinceton | W87-80 (2OT) | 3-0 | 1.000 | - | ESPN2 | Jadwin Gymnasium · Princeton, NJ |
| 4 | Fri Nov 19 | vsPurdue FW | W78-49 | 4-0 | 1.000 | - | | Williams Arena · Minneapolis, MN |
| 5 | Wed Nov 24 | vsJacksonville | W55-44 | 5-0 | 1.000 | - | BTN | Williams Arena · Minneapolis, MN |
| 6 | Tue Nov 30 | atPitt | W54-53 | 6-0 | 1.000 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 7 | Sun Dec 5 | atMississippi St | W81-76 | 7-0 | 1.000 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 8 | Wed Dec 8 | vs19Michigan St | L67-75 | 7-1 | .875 | - | BTN | Williams Arena · Minneapolis, MN |
| 9 | Sat Dec 11 | atMichigan | W75-65 | 8-1 | .889 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Tue Dec 14 | vsTexas A&M-CC | W79-71 | 9-1 | .900 | - | BTN | Williams Arena · Minneapolis, MN |
| 11 | Wed Dec 22 | vsGreen Bay | W72-56 | 10-1 | .909 | - | BTN | Williams Arena · Minneapolis, MN |
| 13 | Tue Jan 4 | vsIllinois | L53-76 | 10-2 | .833 | - | FS1 | Williams Arena · Minneapolis, MN |
| 14 | Sun Jan 9 | atIndiana | L60-73 | 10-3 | .769 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Wed Jan 12 | at10Michigan St | L69-71 | 10-4 | .714 | - | BTN | Breslin Center · East Lansing, MI |
| 16 | Sun Jan 16 | vsIowa | L71-81 | 10-5 | .667 | - | BTN | Williams Arena · Minneapolis, MN |
| 17 | Wed Jan 19 | atPenn State | PPD | 13-17 | .433 | - | | Bryce Jordan Center · University Park, PA |
| 18 | Sat Jan 22 | vsRutgers | W68-65 | 11-5 | .688 | - | BTN | Williams Arena · Minneapolis, MN |
| 19 | Thu Jan 27 | vs16Ohio State | L64-75 | 11-6 | .647 | - | ESPN | Williams Arena · Minneapolis, MN |
| 20 | Sun Jan 30 | at11Wisconsin | L60-66 | 11-7 | .611 | - | BTN | Kohl Center · Madison, WI |
| 21 | Wed Feb 2 | vs4Purdue | L73-88 | 11-8 | .579 | - | BTN | Williams Arena · Minneapolis, MN |
| 22 | Sun Feb 6 | atIowa | L59-71 | 11-9 | .550 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Wed Feb 9 | atNebraska | L65-78 | 11-10 | .524 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 24 | Sat Feb 12 | vsPenn State | W76-70 | 12-10 | .545 | - | BTN | Williams Arena · Minneapolis, MN |
| 25 | Tue Feb 15 | at18Ohio State | L45-70 | 12-11 | .522 | - | BTN | Value City Arena · Columbus, OH |
| 26 | Thu Feb 17 | atPenn State | L46-67 | 12-12 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 27 | Sat Feb 19 | vsNorthwestern | W77-60 | 13-12 | .520 | - | BTN | Williams Arena · Minneapolis, MN |
| 28 | Wed Feb 23 | vs13Wisconsin | L67-68 | 13-13 | .500 | - | BTN | Williams Arena · Minneapolis, MN |
| 29 | Sun Feb 27 | vsIndiana | L79-84 | 13-14 | .481 | - | ESPN2 | Williams Arena · Minneapolis, MN |
| 30 | Wed Mar 2 | atMaryland | L73-84 | 13-15 | .464 | - | BTN | XFINITY Center · College Park, MD |
| 31 | Sun Mar 6 | atNorthwestern | L62-75 | 13-16 | .448 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 32 | Wed Mar 9 | atPenn State | L51-60 | 13-17 | .433 | - | BTN | Bryce Jordan Center · University Park, PA |
