| 1 | Mon Nov 3 | vs Gardner-Webb | W87-60 | 1-0 | 1.000 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 2 | Sat Nov 8 | vsAlcorn St | W95-50 | 2-0 | 1.000 | - | Peacock | Williams Arena · Minneapolis, MN |
| 3 | Wed Nov 12 | atMissouri | L60-83 | 2-1 | .667 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 4 | Sat Nov 15 | vsGreen Bay | W72-65 (OT) | 3-1 | .750 | - | BTN | Williams Arena · Minneapolis, MN |
| 5 | Tue Nov 18 | vsChicago St | W66-54 | 4-1 | .800 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 6 | Sat Nov 22 | vsSan Francisco | L65-77 | 4-2 | .667 | - | Peacock | Williams Arena · Minneapolis, MN |
| 7 | Thu Nov 27 | vsStanford | L68-72 | 4-3 | .571 | - | CBSSN | Williams Arena · Minneapolis, MN |
| 8 | Fri Nov 28 | atSanta Clara | L75-86 | 4-4 | .500 | - | truTV | Leavey Center · Santa Clara, CA |
| 9 | Wed Dec 3 | vs22Indiana | W73-64 | 5-4 | .556 | - | BTN | Williams Arena · Minneapolis, MN |
| 10 | Wed Dec 10 | at6Purdue | L57-85 | 5-5 | .500 | - | BTN | Mackey Arena · West Lafayette, IN |
| 11 | Sun Dec 14 | vsTexas So | W89-53 | 6-5 | .545 | - | BTN | Williams Arena · Minneapolis, MN |
| 12 | Sun Dec 21 | vsCampbell | W78-50 | 7-5 | .583 | - | BTN | Williams Arena · Minneapolis, MN |
| 13 | Mon Dec 29 | vsFairleigh | W60-43 | 8-5 | .615 | - | BTN | Williams Arena · Minneapolis, MN |
| 14 | Sat Jan 3 | atNorthwestern | W84-78 | 9-5 | .643 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 15 | Tue Jan 6 | vs19Iowa | W70-67 | 10-5 | .667 | - | BTN | Williams Arena · Minneapolis, MN |
| 16 | Fri Jan 9 | vsUSC | L69-70 (OT) | 10-6 | .625 | - | BTN | Williams Arena · Minneapolis, MN |
| 17 | Tue Jan 13 | vsWisconsin | L75-78 | 10-7 | .588 | - | BTN | Williams Arena · Minneapolis, MN |
| 18 | Sat Jan 17 | at13Illinois | L67-77 | 10-8 | .556 | - | BTN | State Farm Center · Champaign, IL |
| 19 | Tue Jan 20 | atOhio State | L74-82 (OT) | 10-9 | .526 | - | BTN | Value City Arena · Columbus, OH |
| 20 | Sat Jan 24 | vs7Nebraska | L57-76 | 10-10 | .500 | - | FS1 | Williams Arena · Minneapolis, MN |
| 21 | Wed Jan 28 | atWisconsin | L63-67 | 10-11 | .476 | - | BTN | Kohl Center · Madison, WI |
| 22 | Sun Feb 1 | atPenn State | L75-77 | 10-12 | .455 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 23 | Wed Feb 4 | vs10Michigan St | W76-73 | 11-12 | .478 | - | BTN | Williams Arena · Minneapolis, MN |
| 24 | Sun Feb 8 | vsMaryland | L62-67 | 11-13 | .458 | - | BTN | Williams Arena · Minneapolis, MN |
| 25 | Sat Feb 14 | atWashington | L57-69 | 11-14 | .440 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 26 | Tue Feb 17 | atOregon | W61-44 | 12-14 | .462 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 27 | Sat Feb 21 | vsRutgers | W80-61 | 13-14 | .481 | - | BTN | Williams Arena · Minneapolis, MN |
| 28 | Tue Feb 24 | at3Michigan | L67-77 | 13-15 | .464 | - | BTN | Crisler Center · Ann Arbor, MI |
| 29 | Sat Feb 28 | vsUCLA | W78-73 | 14-15 | .483 | - | FS1 | Williams Arena · Minneapolis, MN |
