| 1 | Wed Nov 25 | vs TBD | W94-84 | 1-0 | 1.000 | - | | Yuengling Center · Tampa, FL |
| 2 | Sat Nov 28 | vs Rhode Island | L68-84 | 1-1 | .500 | - | | Yuengling Center · Tampa, FL |
| 3 | Sun Nov 29 | at Virginia Tech | L58-76 | 1-2 | .333 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 4 | Wed Dec 2 | vs FGCU | W76-57 | 2-2 | .500 | - | | Yuengling Center · Tampa, FL |
| 6 | Tue Dec 8 | vs Stetson | W73-62 | 3-2 | .600 | - | | Yuengling Center · Tampa, FL |
| 7 | Sat Dec 12 | vs Wofford | W58-56 | 4-2 | .667 | - | ESPNEWS | Yuengling Center · Tampa, FL |
| 9 | Wed Dec 16 | at Cincinnati | W74-71 | 5-2 | .714 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 10 | Tue Dec 22 | vs Wichita St | L77-82 (OT) | 5-3 | .625 | - | | Yuengling Center · Tampa, FL |
| 11 | Tue Dec 29 | at Memphis | L57-58 | 5-4 | .556 | - | ESPN2 | FedExForum · Memphis, TN |
| 12 | Sat Jan 2 | vs UCF | W68-61 | 6-4 | .600 | - | | Yuengling Center · Tampa, FL |
| 13 | Wed Jan 6 | vs Tulsa | L51-61 | 6-5 | .545 | - | | Yuengling Center · Tampa, FL |
| 14 | Sat Jan 9 | at E Carolina | W69-63 | 7-5 | .583 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 15 | Thu Jan 14 | vs #11Houston | PPD | 9-13 | .409 | - | | Yuengling Center · Tampa, FL |
| 17 | Sun Jan 24 | atWichita St | PPD | 9-13 | .409 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 18 | Wed Jan 27 | vs Temple | PPD | 9-13 | .409 | - | | Yuengling Center · Tampa, FL |
| 21 | Wed Feb 10 | vs#8Houston | L65-82 | 7-6 | .538 | - | ESPNU | Yuengling Center · Tampa, FL |
| 22 | Sun Feb 14 | vs Tulane | L59-62 | 7-7 | .500 | - | ESPNU | Yuengling Center · Tampa, FL |
| 23 | Wed Feb 17 | atUCF | L65-81 | 7-8 | .467 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 25 | Sun Feb 21 | atTemple | W83-76 | 8-8 | .500 | - | | Liacouras Center · Philadelphia, PA |
| 26 | Wed Feb 24 | vsTemple | L47-65 | 8-9 | .471 | - | ESPNU | Yuengling Center · Tampa, FL |
| 27 | Sun Feb 28 | at#12Houston | L52-98 | 8-10 | .444 | - | ESPNU | Fertitta Center · Houston, TX |
| 28 | Tue Mar 2 | vsMemphis | L52-73 | 8-11 | .421 | - | ESPNU | Yuengling Center · Tampa, FL |
| 29 | Sat Mar 6 | atWichita St | L63-80 | 8-12 | .400 | - | | Charles Koch Arena · Wichita, KS |
| 30 | Thu Mar 11 | vsTemple | W73-71 | 9-12 | .429 | - | ESPNU | Yuengling Center · Tampa, FL |
| 31 | Fri Mar 12 | atWichita St | L67-68 | 9-13 | .409 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
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