| 1 | Tue Nov 5 | vs AR-Pine Bluff | W70-41 | 1-0 | 1.000 | - | | Yuengling Center · Tampa, FL |
| 2 | Sun Nov 10 | vs Boston College | L60-74 | 1-1 | .500 | - | CBS | Yuengling Center · Tampa, FL |
| 3 | Wed Nov 13 | vs IU Indy | L53-70 | 1-2 | .333 | - | | Yuengling Center · Tampa, FL |
| 4 | Thu Nov 21 | vs Wofford | W69-55 | 2-2 | .500 | - | | Yuengling Center · Tampa, FL |
| 5 | Mon Nov 25 | vs Loyola Chicago | W66-55 | 3-2 | .600 | - | | Yuengling Center · Tampa, FL |
| 6 | Tue Nov 26 | vs New Mexico St | L45-65 | 3-3 | .500 | - | | Yuengling Center · Tampa, FL |
| 7 | Wed Nov 27 | at Nebraska | L67-74 | 3-4 | .429 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Mon Dec 2 | vs Furman | W65-55 | 4-4 | .500 | - | | Yuengling Center · Tampa, FL |
| 9 | Fri Dec 6 | vs Dartmouth | W63-44 | 5-4 | .556 | - | | Yuengling Center · Tampa, FL |
| 10 | Sun Dec 15 | vs Drexel | W81-61 | 6-4 | .600 | - | | Yuengling Center · Tampa, FL |
| 11 | Wed Dec 18 | at Utah State | L74-76 (OT) | 6-5 | .545 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 12 | Sat Dec 21 | at Florida St | L60-66 | 6-6 | .500 | - | FS2 | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Sun Dec 29 | vs FAU | W60-58 | 7-6 | .538 | - | | Yuengling Center · Tampa, FL |
| 14 | Wed Jan 1 | at SMU | L64-82 | 7-7 | .500 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 15 | Sat Jan 4 | vs UConn | W75-60 | 8-7 | .533 | - | ESPNU | Yuengling Center · Tampa, FL |
| 16 | Tue Jan 7 | at E Carolina | L59-62 | 8-8 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Sun Jan 12 | vs #21Memphis | L64-68 | 8-9 | .471 | - | ESPN2 | Yuengling Center · Tampa, FL |
| 18 | Sat Jan 18 | at UCF | L54-55 | 8-10 | .444 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 19 | Tue Jan 21 | vs Wichita St | L43-56 | 8-11 | .421 | - | ESPNEWS | Yuengling Center · Tampa, FL |
| 20 | Sun Jan 26 | at #25Houston | L49-68 | 8-12 | .400 | - | CBS | Fertitta Center · Houston, TX |
| 21 | Wed Jan 29 | at Tulane | W66-52 | 9-12 | .429 | - | | Devlin Fieldhouse · New Orleans, LA |
| 22 | Sat Feb 1 | vsUCF | W64-48 | 10-12 | .455 | - | ESPNU | Yuengling Center · Tampa, FL |
| 23 | Sat Feb 8 | atMemphis | W75-73 | 11-12 | .478 | - | CBS | FedExForum · Memphis, TN |
| 24 | Wed Feb 12 | vs#20Houston | L58-62 | 11-13 | .458 | - | ESPNU | Yuengling Center · Tampa, FL |
| 25 | Sat Feb 15 | vs Tulsa | L48-56 | 11-14 | .440 | - | ESPNU | Yuengling Center · Tampa, FL |
| 26 | Thu Feb 20 | atWichita St | L55-65 | 11-15 | .423 | - | CBS | Charles Koch Arena · Wichita, KS |
| 27 | Sun Feb 23 | atUConn | L71-78 | 11-16 | .407 | - | CBS | Gampel Pavilion · Storrs, CT |
| 28 | Wed Feb 26 | vsE Carolina | W73-68 (OT) | 12-16 | .429 | - | | Yuengling Center · Tampa, FL |
| 29 | Sun Mar 1 | at Temple | W64-58 | 13-16 | .448 | - | CBS | Liacouras Center · Philadelphia, PA |
| 30 | Tue Mar 3 | vs Cincinnati | L67-79 | 13-17 | .433 | - | ESPNU | Yuengling Center · Tampa, FL |
| 31 | Sat Mar 7 | vsSMU | W61-60 | 14-17 | .452 | - | | Yuengling Center · Tampa, FL |
