| 1 | Tue Nov 9 | vs C Connecticut | W99-48 | 1-0 | 1.000 | #24 | | Gampel Pavilion · Storrs, CT |
| 2 | Sat Nov 13 | vs Coppin St | W89-54 | 2-0 | 1.000 | #24 | FS2 | Gampel Pavilion · Storrs, CT |
| 3 | Wed Nov 17 | vs Long Island | W93-40 | 3-0 | 1.000 | #23 | FS2 | Gampel Pavilion · Storrs, CT |
| 4 | Sat Nov 20 | vs Binghamton | W87-63 | 4-0 | 1.000 | #23 | FS1 | Gampel Pavilion · Storrs, CT |
| 5 | Wed Nov 24 | at Auburn | W115-109 (2OT) | 5-0 | 1.000 | - | ESPN | Neville Arena · Auburn, AL |
| 6 | Thu Nov 25 | at Michigan St | L60-64 | 5-1 | .833 | - | ESPN | Breslin Center · East Lansing, MI |
| 7 | Fri Nov 26 | vs VCU | W70-63 (OT) | 6-1 | .857 | - | ESPN2 | Gampel Pavilion · Storrs, CT |
| 8 | Tue Nov 30 | vs MD-Eastern | W72-63 | 7-1 | .875 | #17 | CBS | Gampel Pavilion · Storrs, CT |
| 9 | Sat Dec 4 | vs Grambling | W88-59 | 8-1 | .889 | #17 | FS2 | Gampel Pavilion · Storrs, CT |
| 10 | Wed Dec 8 | at West Virginia | L53-56 | 8-2 | .800 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 11 | Sat Dec 11 | vs St Bonaventure | W74-64 | 9-2 | .818 | - | ESPN2 | Gampel Pavilion · Storrs, CT |
| 12 | Sat Dec 18 | vs Providence | L53-57 | 9-3 | .750 | #20 | FOX | Gampel Pavilion · Storrs, CT |
| 13 | Tue Dec 21 | at Marquette | W78-70 | 10-3 | .769 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 14 | Tue Dec 28 | at #23Xavier | PPD | 23-10 | .697 | - | | Cintas Center · Cincinnati, OH |
| 15 | Sat Jan 1 | vs Butler | PPD | 23-10 | .697 | - | | Gampel Pavilion · Storrs, CT |
| 16 | Sat Jan 8 | at #24Seton Hall | L87-90 (OT) | 10-4 | .714 | - | FOX | Prudential Center · Newark, NJ |
| 17 | Wed Jan 12 | vs St John's | W86-78 (OT) | 11-4 | .733 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 19 | Tue Jan 18 | vsButler | W76-59 | 12-4 | .750 | #25 | FS1 | Gampel Pavilion · Storrs, CT |
| 20 | Thu Jan 20 | atButler | W75-56 | 13-4 | .765 | #25 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Tue Jan 25 | vs Georgetown | W96-73 | 14-4 | .778 | #20 | CBS | Gampel Pavilion · Storrs, CT |
| 22 | Sat Jan 29 | at DePaul | W57-50 | 15-4 | .789 | #20 | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Tue Feb 1 | vs Creighton | L55-59 | 15-5 | .750 | #17 | FS1 | Gampel Pavilion · Storrs, CT |
| 24 | Sat Feb 5 | at #12Villanova | L74-85 | 15-6 | .714 | #17 | FOX | Finneran Pavilion · Villanova, PA |
| 25 | Tue Feb 8 | vs#18Marquette | W80-72 | 16-6 | .727 | #24 | FS1 | Gampel Pavilion · Storrs, CT |
| 26 | Fri Feb 11 | at#25Xavier | L68-74 | 16-7 | .696 | #24 | FS1 | Cintas Center · Cincinnati, OH |
| 27 | Sun Feb 13 | atSt John's | W63-60 | 17-7 | .708 | #24 | FOX | Carnesecca Arena · Queens, NY |
| 28 | Wed Feb 16 | vsSeton Hall | W70-65 | 18-7 | .720 | #24 | CBS | Gampel Pavilion · Storrs, CT |
| 29 | Sat Feb 19 | vsXavier | W72-61 | 19-7 | .731 | #24 | FOX | Gampel Pavilion · Storrs, CT |
| 30 | Tue Feb 22 | vs#8Villanova | W71-69 | 20-7 | .741 | #21 | FS1 | Gampel Pavilion · Storrs, CT |
| 31 | Sun Feb 27 | atGeorgetown | W86-77 | 21-7 | .750 | #21 | CBS | Capital One Arena · Washington, D.C. |
| 32 | Wed Mar 2 | atCreighton | L62-64 | 21-8 | .724 | #18 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 33 | Sat Mar 5 | vsDePaul | W75-68 | 22-8 | .733 | #18 | FOX | Gampel Pavilion · Storrs, CT |
| 34 | Thu Mar 10 | vsSeton Hall | W62-52 | 23-8 | .742 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 35 | Fri Mar 11 | atVillanova | L60-63 | 23-9 | .719 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 36 | Thu Mar 17 | vs #12New Mexico St | L63-70 | 23-10 | .697 | #5 | TNT | Gampel Pavilion · Storrs, CT |
