| 1 | Wed Nov 6 | vs Sacred Heart | W92-56 | 1-0 | 1.000 | #3 | FS1 | Gampel Pavilion · Storrs, CT |
| 2 | Sat Nov 9 | vs New Hampshire | W92-53 | 2-0 | 1.000 | #3 | FS2 | Gampel Pavilion · Storrs, CT |
| 3 | Wed Nov 13 | vs Le Moyne | W90-49 | 3-0 | 1.000 | #3 | FS1 | Gampel Pavilion · Storrs, CT |
| 4 | Tue Nov 19 | vs E Texas A&M | W81-46 | 4-0 | 1.000 | #2 | FS1 | Gampel Pavilion · Storrs, CT |
| 5 | Mon Nov 25 | vs Memphis | L97-99 (OT) | 4-1 | .800 | #2 | ESPN2 | Gampel Pavilion · Storrs, CT |
| 6 | Tue Nov 26 | at Colorado | L72-73 | 4-2 | .667 | #2 | ESPN2 | CU Events Center · Boulder, CO |
| 7 | Wed Nov 27 | at Dayton | L67-85 | 4-3 | .571 | #2 | ESPN2 | UD Arena · Dayton, OH |
| 8 | Sat Nov 30 | vs MD-Eastern | W99-45 | 5-3 | .625 | #2 | Peacock | Gampel Pavilion · Storrs, CT |
| 9 | Wed Dec 4 | vs #15Baylor | W76-72 | 6-3 | .667 | #25 | FS1 | Gampel Pavilion · Storrs, CT |
| 10 | Sun Dec 8 | at Texas | W76-65 | 7-3 | .700 | #25 | ESPN | Moody Center · Austin, TX |
| 11 | Sat Dec 14 | vs #8Gonzaga | W77-71 | 8-3 | .727 | #18 | FOX | Gampel Pavilion · Storrs, CT |
| 12 | Wed Dec 18 | vs Xavier | W94-89 (OT) | 9-3 | .750 | #11 | FS1 | Gampel Pavilion · Storrs, CT |
| 13 | Sat Dec 21 | at Butler | W78-74 | 10-3 | .769 | #11 | Peacock | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Wed Jan 1 | at DePaul | W81-68 | 11-3 | .786 | #11 | CBS | Wintrust Arena · Chicago, IL |
| 15 | Sun Jan 5 | vs Providence | W87-84 | 12-3 | .800 | #11 | NBC | Gampel Pavilion · Storrs, CT |
| 16 | Wed Jan 8 | at Villanova | L66-68 | 12-4 | .750 | #9 | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Sat Jan 11 | at Georgetown | W68-60 | 13-4 | .765 | #9 | FOX | Capital One Arena · Washington, D.C. |
| 18 | Sat Jan 18 | vs Creighton | L63-68 | 13-5 | .722 | #14 | FOX | Gampel Pavilion · Storrs, CT |
| 19 | Tue Jan 21 | vsButler | W80-78 (OT) | 14-5 | .737 | #19 | FS1 | Gampel Pavilion · Storrs, CT |
| 20 | Sat Jan 25 | atXavier | L72-76 | 14-6 | .700 | #19 | FOX | Cintas Center · Cincinnati, OH |
| 21 | Wed Jan 29 | vsDePaul | W72-61 | 15-6 | .714 | #25 | Peacock | Gampel Pavilion · Storrs, CT |
| 22 | Sat Feb 1 | at #9Marquette | W77-69 | 16-6 | .727 | #25 | FOX | Fiserv Forum · Milwaukee, WI |
| 23 | Fri Feb 7 | vs #12St John's | L62-68 | 16-7 | .696 | #19 | FOX | Gampel Pavilion · Storrs, CT |
| 24 | Tue Feb 11 | at#24Creighton | W70-66 | 17-7 | .708 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 25 | Sat Feb 15 | at Seton Hall | L68-69 (OT) | 17-8 | .680 | - | FOX | Prudential Center · Newark, NJ |
| 26 | Tue Feb 18 | vsVillanova | W66-59 | 18-8 | .692 | - | FS1 | Gampel Pavilion · Storrs, CT |
