| 1 | Mon Nov 7 | vs Stonehill | W85-54 | 1-0 | 1.000 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 2 | Fri Nov 11 | vs Boston Univ | W86-57 | 2-0 | 1.000 | - | FS2 | Gampel Pavilion · Storrs, CT |
| 3 | Tue Nov 15 | vs Buffalo | W84-64 | 3-0 | 1.000 | #25 | CBS | Gampel Pavilion · Storrs, CT |
| 4 | Fri Nov 18 | vs UNC Wilmington | W86-50 | 4-0 | 1.000 | #25 | FS2 | Gampel Pavilion · Storrs, CT |
| 5 | Sun Nov 20 | vs Delaware St | W95-60 | 5-0 | 1.000 | #25 | FS1 | Gampel Pavilion · Storrs, CT |
| 6 | Thu Nov 24 | at Oregon | W83-59 | 6-0 | 1.000 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 7 | Fri Nov 25 | at Alabama | W82-67 | 7-0 | 1.000 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 8 | Sun Nov 27 | vs Iowa State | W71-53 | 8-0 | 1.000 | - | ESPN | Gampel Pavilion · Storrs, CT |
| 9 | Thu Dec 1 | vs Oklahoma St | W74-64 | 9-0 | 1.000 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 10 | Wed Dec 7 | at Florida | W75-54 | 10-0 | 1.000 | #5 | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 11 | Sat Dec 10 | vs Long Island | W114-61 | 11-0 | 1.000 | #5 | FS1 | Gampel Pavilion · Storrs, CT |
| 12 | Sat Dec 17 | at Butler | W68-46 | 12-0 | 1.000 | #3 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Tue Dec 20 | vs Georgetown | W84-73 | 13-0 | 1.000 | #2 | FS1 | Gampel Pavilion · Storrs, CT |
| 14 | Wed Dec 28 | vs Villanova | W74-66 | 14-0 | 1.000 | #2 | FS1 | Gampel Pavilion · Storrs, CT |
| 15 | Sat Dec 31 | at #22Xavier | L73-83 | 14-1 | .933 | #2 | FOX | Cintas Center · Cincinnati, OH |
| 16 | Wed Jan 4 | at Providence | L61-73 | 14-2 | .875 | #4 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 17 | Sat Jan 7 | vs Creighton | W69-60 | 15-2 | .882 | #4 | FOX | Gampel Pavilion · Storrs, CT |
| 18 | Wed Jan 11 | at #25Marquette | L76-82 | 15-3 | .833 | #6 | CBS | Fiserv Forum · Milwaukee, WI |
| 19 | Sun Jan 15 | vs St John's | L74-85 | 15-4 | .789 | #6 | FS1 | Gampel Pavilion · Storrs, CT |
| 20 | Wed Jan 18 | at Seton Hall | L66-67 | 15-5 | .750 | #15 | FS1 | Prudential Center · Newark, NJ |
| 21 | Sun Jan 22 | vsButler | W86-56 | 16-5 | .762 | #15 | FOX | Gampel Pavilion · Storrs, CT |
| 22 | Wed Jan 25 | vs#13Xavier | L79-82 | 16-6 | .727 | #19 | FS1 | Gampel Pavilion · Storrs, CT |
| 23 | Tue Jan 31 | at DePaul | W90-76 | 17-6 | .739 | #24 | FS1 | Wintrust Arena · Chicago, IL |
| 24 | Sat Feb 4 | atGeorgetown | W68-62 | 18-6 | .750 | #24 | FS1 | Capital One Arena · Washington, D.C. |
| 25 | Tue Feb 7 | vs#10Marquette | W87-72 | 19-6 | .760 | #21 | FS1 | Gampel Pavilion · Storrs, CT |
| 26 | Sat Feb 11 | at#23Creighton | L53-56 | 19-7 | .731 | #21 | FOX | CHI Health Center Omaha · Omaha, NE |
| 27 | Sat Feb 18 | vsSeton Hall | W64-55 | 20-7 | .741 | #20 | FOX | Gampel Pavilion · Storrs, CT |
| 28 | Wed Feb 22 | vs#20Providence | W87-69 | 21-7 | .750 | #18 | FS1 | Gampel Pavilion · Storrs, CT |
| 29 | Sat Feb 25 | atSt John's | W95-86 | 22-7 | .759 | #18 | CBS | Carnesecca Arena · Queens, NY |
| 30 | Wed Mar 1 | vsDePaul | W88-59 | 23-7 | .767 | #14 | CBS | Gampel Pavilion · Storrs, CT |
| 31 | Sat Mar 4 | atVillanova | W71-59 | 24-7 | .774 | #14 | FOX | Finneran Pavilion · Villanova, PA |
| 32 | Thu Mar 9 | vsProvidence | W73-66 | 25-7 | .781 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 33 | Fri Mar 10 | atMarquette | L68-70 | 25-8 | .758 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 34 | Fri Mar 17 | vs #13Iona | W87-63 | 26-8 | .765 | #4 | TBS | Gampel Pavilion · Storrs, CT |
| 35 | Sun Mar 19 | vs #5Saint Mary's | W70-55 | 27-8 | .771 | #4 | TNT | Gampel Pavilion · Storrs, CT |
| 36 | Thu Mar 23 | vs #8Arkansas | W88-65 | 28-8 | .778 | #4 | CBS | Gampel Pavilion · Storrs, CT |
| 37 | Sat Mar 25 | at #3Gonzaga | W82-54 | 29-8 | .784 | #4 | TBS | McCarthey Athletic Center · Spokane, WA |
| 38 | Sat Apr 1 | vs #5Miami | W72-59 | 30-8 | .789 | #4 | CBS | Gampel Pavilion · Storrs, CT |
| 39 | Mon Apr 3 | vs #5SDSU | W76-59 | 31-8 | .795 | #4 | CBS | Gampel Pavilion · Storrs, CT |
