| 1 | Fri Nov 8 | vs Sacred Heart | W89-67 | 1-0 | 1.000 | - | | Gampel Pavilion · Storrs, CT |
| 2 | Wed Nov 13 | vsSaint Joseph's | L87-96 | 1-1 | .500 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 3 | Sun Nov 17 | vs15Florida | W62-59 | 2-1 | .667 | - | ESPN | Gampel Pavilion · Storrs, CT |
| 4 | Thu Nov 21 | vsBuffalo | W79-68 | 3-1 | .750 | - | ESPNU | TD Arena · Charleston, SC |
| 5 | Fri Nov 22 | vsXavier | L74-75 (2OT) | 3-2 | .600 | - | ESPNU | TD Arena · Charleston, SC |
| 6 | Sun Nov 24 | vsMiami | W80-55 | 4-2 | .667 | - | ESPN2 | TD Arena · Charleston, SC |
| 7 | Sun Dec 1 | vsMaine | W64-40 | 5-2 | .714 | - | | Gampel Pavilion · Storrs, CT |
| 8 | Wed Dec 4 | vsIona | W80-62 | 6-2 | .750 | - | | Gampel Pavilion · Storrs, CT |
| 9 | Tue Dec 10 | vsIndiana | L54-57 | 6-3 | .667 | - | ESPN | Gampel Pavilion · Storrs, CT |
| 10 | Wed Dec 18 | vsSaint Peter's | W66-56 | 7-3 | .700 | - | | Gampel Pavilion · Storrs, CT |
| 11 | Sun Dec 22 | vsNew Hampshire | W88-62 | 8-3 | .727 | - | | Gampel Pavilion · Storrs, CT |
| 12 | Sun Dec 29 | vsNJIT | W69-47 | 9-3 | .750 | - | | Gampel Pavilion · Storrs, CT |
| 13 | Wed Jan 1 | atCincinnati | L51-67 | 9-4 | .692 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 4 | atSouth Florida | L60-75 | 9-5 | .643 | - | ESPNU | Yuengling Center · Tampa, FL |
| 15 | Wed Jan 8 | vsTulane | W67-61 | 10-5 | .667 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 16 | Sun Jan 12 | vs23Wichita St | L86-89 (2OT) | 10-6 | .625 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 17 | Sat Jan 18 | at14Villanova | L55-61 | 10-7 | .588 | - | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 18 | Thu Jan 23 | at25Houston | L59-63 | 10-8 | .556 | - | ESPNU | Fertitta Center · Houston, TX |
| 19 | Sun Jan 26 | vsTulsa | L75-79 (OT) | 10-9 | .526 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 20 | Wed Jan 29 | vsTemple | W78-63 | 11-9 | .550 | - | ESPNEWS | Gampel Pavilion · Storrs, CT |
| 21 | Sat Feb 1 | atMemphis | L63-70 | 11-10 | .524 | - | CBS | FedExForum · Memphis, TN |
| 22 | Thu Feb 6 | atTulsa | W72-56 | 12-10 | .545 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Sun Feb 9 | vsCincinnati | W72-71 (OT) | 13-10 | .565 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 24 | Wed Feb 12 | atSMU | L75-79 | 13-11 | .542 | - | ESPNEWS | Moody Coliseum · Dallas, TX |
| 25 | Sun Feb 16 | vsMemphis | W64-61 | 14-11 | .560 | - | ESPN | Gampel Pavilion · Storrs, CT |
| 26 | Thu Feb 20 | atTemple | L89-93 (2OT) | 14-12 | .538 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 27 | Sun Feb 23 | vsSouth Florida | W78-71 | 15-12 | .556 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 28 | Wed Feb 26 | vsUCF | W81-65 | 16-12 | .571 | - | ESPNU | Gampel Pavilion · Storrs, CT |
| 29 | Sat Feb 29 | atE Carolina | W84-63 | 17-12 | .586 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Thu Mar 5 | vs21Houston | W77-71 | 18-12 | .600 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 31 | Sun Mar 8 | atTulane | W80-76 | 19-12 | .613 | - | ESPNU | Devlin Fieldhouse · New Orleans, LA |
