| 1 | Mon Nov 6 | vs N Arizona | W95-52 | 1-0 | 1.000 | #6 | | Gampel Pavilion · Storrs, CT |
| 2 | Sat Nov 11 | vs Stonehill | W107-67 | 2-0 | 1.000 | #6 | FS2 | Gampel Pavilion · Storrs, CT |
| 3 | Tue Nov 14 | vs Miss Valley St | W87-53 | 3-0 | 1.000 | #5 | FS2 | Gampel Pavilion · Storrs, CT |
| 4 | Sun Nov 19 | at Indiana | W77-57 | 4-0 | 1.000 | #5 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Mon Nov 20 | at #15Texas | W81-71 | 5-0 | 1.000 | #5 | ESPNU | Moody Center · Austin, TX |
| 6 | Fri Nov 24 | vs Manhattan | W90-60 | 6-0 | 1.000 | #5 | FS1 | Gampel Pavilion · Storrs, CT |
| 7 | Mon Nov 27 | vs New Hampshire | W84-64 | 7-0 | 1.000 | #4 | CBS | Gampel Pavilion · Storrs, CT |
| 8 | Fri Dec 1 | at #5Kansas | L65-69 | 7-1 | .875 | #4 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Tue Dec 5 | vs #9UNC | W87-76 | 8-1 | .889 | #5 | ESPN | Gampel Pavilion · Storrs, CT |
| 10 | Sat Dec 9 | vs AR-Pine Bluff | W101-63 | 9-1 | .900 | #5 | FS2 | Gampel Pavilion · Storrs, CT |
| 11 | Fri Dec 15 | at #10Gonzaga | W76-63 | 10-1 | .909 | #5 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 12 | Wed Dec 20 | at Seton Hall | L60-75 | 10-2 | .833 | #5 | CBS | Prudential Center · Newark, NJ |
| 13 | Sat Dec 23 | vs St John's | W69-65 | 11-2 | .846 | #5 | FOX | Gampel Pavilion · Storrs, CT |
| 14 | Tue Jan 2 | vs DePaul | W85-56 | 12-2 | .857 | #4 | FS1 | Gampel Pavilion · Storrs, CT |
| 15 | Fri Jan 5 | at Butler | W88-81 | 13-2 | .867 | #4 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 16 | Wed Jan 10 | at Xavier | W80-75 | 14-2 | .875 | #4 | FS1 | Cintas Center · Cincinnati, OH |
| 17 | Sun Jan 14 | vs Georgetown | W80-67 | 15-2 | .882 | #4 | FOX | Gampel Pavilion · Storrs, CT |
| 18 | Wed Jan 17 | vs #18Creighton | W62-48 | 16-2 | .889 | #1 | FS1 | Gampel Pavilion · Storrs, CT |
| 19 | Sat Jan 20 | at Villanova | W66-65 | 17-2 | .895 | #1 | FS1 | Finneran Pavilion · Villanova, PA |
| 20 | Sun Jan 28 | vsXavier | W99-56 | 18-2 | .900 | #1 | FS1 | Gampel Pavilion · Storrs, CT |
| 21 | Wed Jan 31 | vs Providence | W74-65 | 19-2 | .905 | #1 | FS1 | Gampel Pavilion · Storrs, CT |
| 22 | Sat Feb 3 | atSt John's | W77-64 | 20-2 | .909 | #1 | FOX | Carnesecca Arena · Queens, NY |
| 23 | Tue Feb 6 | vsButler | W71-62 | 21-2 | .913 | #1 | FS1 | Gampel Pavilion · Storrs, CT |
| 24 | Sat Feb 10 | atGeorgetown | W89-64 | 22-2 | .917 | #1 | FS1 | Capital One Arena · Washington, D.C. |
| 25 | Wed Feb 14 | atDePaul | W101-65 | 23-2 | .920 | #1 | CBS | Wintrust Arena · Chicago, IL |
| 26 | Sat Feb 17 | vs #4Marquette | W81-53 | 24-2 | .923 | #1 | FOX | Gampel Pavilion · Storrs, CT |
| 27 | Tue Feb 20 | at#15Creighton | L66-85 | 24-3 | .889 | #1 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 28 | Sat Feb 24 | vsVillanova | W78-54 | 25-3 | .893 | #1 | FOX | Gampel Pavilion · Storrs, CT |
| 29 | Sun Mar 3 | vsSeton Hall | W91-61 | 26-3 | .897 | #3 | CBS | Gampel Pavilion · Storrs, CT |
| 30 | Wed Mar 6 | at#8Marquette | W74-67 | 27-3 | .900 | #2 | FS1 | Fiserv Forum · Milwaukee, WI |
| 31 | Sat Mar 9 | atProvidence | W74-60 | 28-3 | .903 | #2 | FOX | Amica Mutual Pavilion · Providence, RI |
| 32 | Thu Mar 14 | vsXavier | W87-60 | 29-3 | .906 | #2 | FS1 | Gampel Pavilion · Storrs, CT |
| 33 | Fri Mar 15 | vsSt John's | W95-90 | 30-3 | .909 | #2 | FOX | Gampel Pavilion · Storrs, CT |
| 34 | Sat Mar 16 | vs#10Marquette | W73-57 | 31-3 | .912 | #2 | FOX | Gampel Pavilion · Storrs, CT |
| 35 | Fri Mar 22 | vs #16Stetson | W91-52 | 32-3 | .914 | #1 | CBS | Gampel Pavilion · Storrs, CT |
| 36 | Sun Mar 24 | vs #9Northwestern | W75-58 | 33-3 | .917 | #1 | truTV | Gampel Pavilion · Storrs, CT |
| 37 | Thu Mar 28 | vs #5SDSU | W82-52 | 34-3 | .919 | #1 | TBS | Gampel Pavilion · Storrs, CT |
| 38 | Sat Mar 30 | vs #3Illinois | W77-52 | 35-3 | .921 | #1 | TBS | Gampel Pavilion · Storrs, CT |
| 39 | Sat Apr 6 | vs #4Alabama | W86-72 | 36-3 | .923 | #1 | TBS | Gampel Pavilion · Storrs, CT |
| 40 | Mon Apr 8 | vs #1Purdue | W75-60 | 37-3 | .925 | #1 | TBS | Gampel Pavilion · Storrs, CT |
