| 1 | Mon Nov 3 | vs New Haven | 7:00 PM | 0-0 | .000 | #4 | | Gampel Pavilion · Storrs, CT |
| 2 | Fri Nov 7 | vsUMass Lowell | 7:30 PM | 17-15 | .531 | #4 | Peacock | Gampel Pavilion · Storrs, CT |
| 3 | Mon Nov 10 | vsColumbia | 6:30 PM | 12-15 | .444 | #4 | | Gampel Pavilion · Storrs, CT |
| 4 | Sat Nov 15 | at#8BYU | 7:00 PM | 26-10 | .722 | #4 | FOX | Marriott Center · Provo, UT |
| 5 | Wed Nov 19 | vs#13Arizona | 7:00 PM | 24-13 | .649 | #4 | FS1 | Gampel Pavilion · Storrs, CT |
| 6 | Sun Nov 23 | vsBryant | 6:00 PM | 23-12 | .657 | #4 | | Gampel Pavilion · Storrs, CT |
| 7 | Fri Nov 28 | at#17Illinois | 12:30 PM | 22-13 | .629 | #4 | | State Farm Center · Champaign, IL |
| 8 | Tue Dec 2 | at#19Kansas | 9:00 PM | 21-13 | .618 | #4 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Fri Dec 5 | vsE Texas A&M | 7:30 PM | 5-26 | .161 | #4 | | Gampel Pavilion · Storrs, CT |
| 10 | Tue Dec 9 | vs#3Florida | 9:00 PM | 36-4 | .900 | #4 | ESPN | Gampel Pavilion · Storrs, CT |
| 11 | Fri Dec 12 | vsTexas | 8:00 PM | 19-16 | .543 | #4 | | Gampel Pavilion · Storrs, CT |
| 12 | Tue Dec 16 | vsButler | 8:30 PM | 15-20 | .429 | #4 | | Gampel Pavilion · Storrs, CT |
| 13 | Sun Dec 21 | atDePaul | 4:30 PM | 14-20 | .412 | #4 | | Wintrust Arena · Chicago, IL |
| 14 | Wed Dec 31 | atXavier | 5:00 PM | 22-12 | .647 | #4 | | Cintas Center · Cincinnati, OH |
| 15 | Sun Jan 4 | vsMarquette | 2:00 PM | 23-11 | .676 | #4 | | Gampel Pavilion · Storrs, CT |
| 16 | Wed Jan 7 | atProvidence | 7:00 PM | 12-20 | .375 | #4 | | Amica Mutual Pavilion · Providence, RI |
| 17 | Sat Jan 10 | vsDePaul | 12:30 PM | 14-20 | .412 | #4 | | Gampel Pavilion · Storrs, CT |
| 18 | Tue Jan 13 | atSeton Hall | 8:00 PM | 7-25 | .219 | #4 | | Prudential Center · Newark, NJ |
| 19 | Sat Jan 17 | atGeorgetown | 12:00 PM | 18-16 | .529 | #4 | | Capital One Arena · Washington, D.C. |
| 20 | Sat Jan 24 | vsVillanova | 12:30 PM | 21-15 | .583 | #4 | | Gampel Pavilion · Storrs, CT |
| 21 | Tue Jan 27 | vsProvidence | 7:30 PM | 12-20 | .375 | #4 | | Gampel Pavilion · Storrs, CT |
| 22 | Sat Jan 31 | at#23Creighton | 8:00 PM | 25-11 | .694 | #4 | | CHI Health Center Omaha · Omaha, NE |
| 23 | Tue Feb 3 | vsXavier | 7:00 PM | 22-12 | .647 | #4 | | Gampel Pavilion · Storrs, CT |
| 24 | Fri Feb 6 | at#5St John's | 8:00 PM | 31-5 | .861 | #4 | | Carnesecca Arena · Queens, NY |
| 25 | Wed Feb 11 | atButler | 7:30 PM | 15-20 | .429 | #4 | | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Sat Feb 14 | vsGeorgetown | 8:00 PM | 18-16 | .529 | #4 | | Gampel Pavilion · Storrs, CT |
| 27 | Wed Feb 18 | vs#23Creighton | 7:00 PM | 25-11 | .694 | #4 | | Gampel Pavilion · Storrs, CT |
| 28 | Sat Feb 21 | atVillanova | 7:00 PM | 21-15 | .583 | #4 | | Finneran Pavilion · Villanova, PA |
| 29 | Wed Feb 25 | vs#5St John's | 7:00 PM | 31-5 | .861 | #4 | | Gampel Pavilion · Storrs, CT |
| 30 | Sat Feb 28 | vsSeton Hall | 12:00 PM | 7-25 | .219 | #4 | | Gampel Pavilion · Storrs, CT |
| 31 | Sat Mar 7 | atMarquette | 12:30 PM | 23-11 | .676 | #4 | | Fiserv Forum · Milwaukee, WI |
