| 1 | Tue Nov 5 | vs TBD | W96-77 | 1-0 | 1.000 | - | | Nutter Center · Dayton, OH |
| 2 | Sat Nov 9 | at Miami OH | W88-81 | 2-0 | 1.000 | - | | Millett Hall · Oxford, OH |
| 3 | Tue Nov 12 | at Tennessee Tech | W85-80 (OT) | 3-0 | 1.000 | - | | Hooper Eblen Center · Cookeville, TN |
| 4 | Sat Nov 16 | vs Kent State | L71-72 | 3-1 | .750 | - | | Nutter Center · Dayton, OH |
| 5 | Wed Nov 20 | vsTBD | W88-51 | 4-1 | .800 | - | | Nutter Center · Dayton, OH |
| 6 | Mon Nov 25 | vs Weber St | W72-57 | 5-1 | .833 | - | | Nutter Center · Dayton, OH |
| 7 | Tue Nov 26 | vs La Salle | L70-72 | 5-2 | .714 | - | | Nutter Center · Dayton, OH |
| 8 | Wed Nov 27 | atMiami OH | W71-66 | 6-2 | .750 | - | | Millett Hall · Oxford, OH |
| 9 | Tue Dec 3 | vs Western KY | W76-74 | 7-2 | .778 | - | | Nutter Center · Dayton, OH |
| 10 | Sat Dec 7 | vs Indiana St | L77-84 (OT) | 7-3 | .700 | - | | Nutter Center · Dayton, OH |
| 11 | Thu Dec 12 | vs Southern | W85-62 | 8-3 | .727 | - | | Nutter Center · Dayton, OH |
| 12 | Tue Dec 17 | vs Miss Valley St | W92-50 | 9-3 | .750 | - | | Nutter Center · Dayton, OH |
| 13 | Sat Dec 21 | at Toledo | W79-72 | 10-3 | .769 | - | | Savage Arena · Toledo, OH |
| 14 | Sat Dec 28 | vs Green Bay | W90-84 | 11-3 | .786 | - | | Nutter Center · Dayton, OH |
| 15 | Mon Dec 30 | vs Milwaukee | W82-70 | 12-3 | .800 | - | | Nutter Center · Dayton, OH |
| 16 | Fri Jan 3 | at Oakland | W96-69 | 13-3 | .813 | - | ESPNU | Athletics Center O'rena · Rochester, MI |
| 17 | Sun Jan 5 | at Detroit Mercy | W70-69 | 14-3 | .824 | - | | Calihan Hall · Detroit, MI |
| 18 | Fri Jan 10 | at IU Indy | W84-70 | 15-3 | .833 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Sun Jan 12 | at UIC | L72-76 | 15-4 | .789 | - | | Credit Union 1 Arena · Chicago, IL |
| 20 | Thu Jan 16 | vs Cleveland St | W75-62 | 16-4 | .800 | - | | Nutter Center · Dayton, OH |
| 21 | Sat Jan 18 | vs Youngstown St | W79-72 | 17-4 | .810 | - | | Nutter Center · Dayton, OH |
| 22 | Fri Jan 24 | vs N Kentucky | W95-63 | 18-4 | .818 | - | ESPNU | Nutter Center · Dayton, OH |
| 23 | Fri Jan 31 | atMilwaukee | W65-61 | 19-4 | .826 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Sun Feb 2 | atGreen Bay | L89-92 | 19-5 | .792 | - | | Resch Center · Ashwaubenon, WI |
| 25 | Thu Feb 6 | vsDetroit Mercy | W98-86 | 20-5 | .800 | - | | Nutter Center · Dayton, OH |
| 26 | Sat Feb 8 | vsOakland | W83-71 | 21-5 | .808 | - | | Nutter Center · Dayton, OH |
| 27 | Fri Feb 14 | vsUIC | W75-58 | 22-5 | .815 | - | ESPN2 | Nutter Center · Dayton, OH |
| 28 | Sun Feb 16 | vsIU Indy | W106-66 | 23-5 | .821 | - | | Nutter Center · Dayton, OH |
| 29 | Thu Feb 20 | atYoungstown St | L70-88 | 23-6 | .793 | - | | Beeghly Center · Youngstown, OH |
| 30 | Sat Feb 22 | atCleveland St | W81-74 (OT) | 24-6 | .800 | - | | Wolstein Center · Cleveland, OH |
| 31 | Fri Feb 28 | atN Kentucky | W64-62 | 25-6 | .806 | - | ESPNU | Truist Arena · Highland Heights, KY |
| 32 | Mon Mar 9 | vsUIC | L56-73 | 25-7 | .781 | - | ESPNU | Nutter Center · Dayton, OH |
