| 1 | Mon Nov 4 | at 23Kentucky | L62-103 | 0-1 | .000 | - | ESPNU | Rupp Arena · Lexington, KY |
| 2 | Wed Nov 6 | vsTBD | W89-60 | 1-1 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 3 | Sat Nov 9 | atMiami OH | W81-68 | 2-1 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 4 | Wed Nov 13 | atToledo | L77-86 | 2-2 | .500 | - | ESPN+ | Savage Arena · Toledo, OH |
| 5 | Sat Nov 16 | vsTBD | W92-56 | 3-2 | .600 | - | ESPN+ | Nutter Center · Dayton, OH |
| 6 | Thu Nov 21 | vsPrinceton | W80-62 | 4-2 | .667 | - | ESPN+ | The HTC Center · Conway, SC |
| 7 | Fri Nov 22 | vsBradley | L74-77 | 4-3 | .571 | - | ESPNU | The HTC Center · Conway, SC |
| 8 | Sun Nov 24 | vsSouth Florida | L72-73 | 4-4 | .500 | - | ESPN2 | The HTC Center · Conway, SC |
| 9 | Sat Nov 30 | vsAir Force | W70-57 | 5-4 | .556 | - | ESPN+ | Nutter Center · Dayton, OH |
| 10 | Thu Dec 5 | atOakland | L64-66 | 5-5 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 11 | Sat Dec 7 | atDetroit Mercy | W80-72 | 6-5 | .545 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 12 | Wed Dec 11 | vsMarshall | W88-79 | 7-5 | .583 | - | ESPN+ | Nutter Center · Dayton, OH |
| 13 | Wed Dec 18 | vsYoungstown St | L70-80 | 7-6 | .538 | - | ESPN+ | Nutter Center · Dayton, OH |
| 14 | Sat Dec 21 | atE Michigan | L82-86 | 7-7 | .500 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 15 | Sun Dec 29 | atCleveland St | L64-78 | 7-8 | .467 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 16 | Thu Jan 2 | vsGreen Bay | W74-51 | 8-8 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 17 | Thu Jan 9 | vsOakland | W66-62 | 9-8 | .529 | - | ESPN+ | Nutter Center · Dayton, OH |
| 18 | Sun Jan 12 | atRobert Morris | L72-75 | 9-9 | .500 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 19 | Wed Jan 15 | vsPurdue FW | L113-120 (2OT) | 9-10 | .474 | - | ESPN+ | Nutter Center · Dayton, OH |
| 20 | Sat Jan 18 | atN Kentucky | W78-70 | 10-10 | .500 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 21 | Wed Jan 22 | vsMilwaukee | L79-95 | 10-11 | .476 | - | ESPN+ | Nutter Center · Dayton, OH |
| 22 | Sat Jan 25 | vsDetroit Mercy | W67-50 | 11-11 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 23 | Thu Jan 30 | atYoungstown St | L86-88 | 11-12 | .478 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 24 | Sun Feb 2 | vsRobert Morris | W66-64 | 12-12 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 25 | Wed Feb 5 | atPurdue FW | L64-87 | 12-13 | .480 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Sat Feb 8 | vsIU Indy | W91-73 | 13-13 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 27 | Fri Feb 14 | atMilwaukee | L80-88 (OT) | 13-14 | .481 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Sun Feb 16 | atGreen Bay | L68-79 | 13-15 | .464 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 29 | Fri Feb 21 | vsN Kentucky | L76-80 | 13-16 | .448 | - | ESPN+ | Nutter Center · Dayton, OH |
| 30 | Thu Feb 27 | vsCleveland St | W82-76 | 14-16 | .467 | - | ESPN2 | Nutter Center · Dayton, OH |
| 31 | Sat Mar 1 | atIU Indy | L84-91 | 14-17 | .452 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Tue Mar 4 | vsIU Indy | W98-85 | 15-17 | .469 | - | ESPN+ | Nutter Center · Dayton, OH |
| 33 | Thu Mar 6 | atRobert Morris | L62-83 | 15-18 | .455 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
