| 1 | Tue Nov 9 | vs TBD | W86-53 | 1-0 | 1.000 | - | | Nutter Center · Dayton, OH |
| 2 | Fri Nov 12 | at Marshall | L88-96 | 1-1 | .500 | - | | Cam Henderson Center · Huntington, WV |
| 3 | Tue Nov 16 | at #6Purdue | L52-96 | 1-2 | .333 | - | BTN | Mackey Arena · West Lafayette, IN |
| 4 | Mon Nov 22 | at G Washington | L63-74 | 1-3 | .250 | - | | Charles E. Smith Center · Washington, D.C. |
| 5 | Tue Nov 23 | at JMU | L76-78 | 1-4 | .200 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 6 | Wed Nov 24 | vs Long Beach St | L76-85 | 1-5 | .167 | - | | Nutter Center · Dayton, OH |
| 7 | Thu Dec 2 | at Purdue FW | W86-73 | 2-5 | .286 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Sat Dec 4 | at Cleveland St | L75-85 | 2-6 | .250 | - | | Wolstein Center · Cleveland, OH |
| 9 | Wed Dec 15 | vs Akron | L48-66 | 2-7 | .222 | - | | Nutter Center · Dayton, OH |
| 10 | Sat Dec 18 | vs Tennessee Tech | W72-63 | 3-7 | .300 | - | | Nutter Center · Dayton, OH |
| 11 | Tue Dec 21 | at NC State | W84-70 | 4-7 | .364 | - | | PNC Arena · Raleigh, NC |
| 12 | Thu Dec 30 | vs Milwaukee | W80-75 | 5-7 | .417 | - | | Nutter Center · Dayton, OH |
| 13 | Sat Jan 1 | vs Green Bay | W72-69 | 6-7 | .462 | - | | Nutter Center · Dayton, OH |
| 14 | Thu Jan 6 | vs UIC | W90-72 | 7-7 | .500 | - | | Nutter Center · Dayton, OH |
| 15 | Sat Jan 8 | vs IU Indy | W72-58 | 8-7 | .533 | - | | Nutter Center · Dayton, OH |
| 16 | Mon Jan 10 | at N Kentucky | PPD | 22-14 | .611 | - | | Truist Arena · Highland Heights, KY |
| 17 | Thu Jan 13 | at Robert Morris | W75-73 | 9-7 | .563 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Sat Jan 15 | at Youngstown St | L87-90 | 9-8 | .529 | - | | Beeghly Center · Youngstown, OH |
| 19 | Thu Jan 20 | atIU Indy | W73-45 | 10-8 | .556 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Sat Jan 22 | atUIC | W97-81 | 11-8 | .579 | - | | Credit Union 1 Arena · Chicago, IL |
| 21 | Tue Jan 25 | atN Kentucky | L63-73 | 11-9 | .550 | - | | Truist Arena · Highland Heights, KY |
| 22 | Fri Jan 28 | vsCleveland St | L67-71 | 11-10 | .524 | - | ESPNU | Nutter Center · Dayton, OH |
| 23 | Sun Jan 30 | vsPurdue FW | W75-63 | 12-10 | .545 | - | | Nutter Center · Dayton, OH |
| 24 | Thu Feb 3 | vs Detroit Mercy | PPD | 22-14 | .611 | - | | Nutter Center · Dayton, OH |
| 25 | Fri Feb 4 | vsDetroit Mercy | W90-59 | 13-10 | .565 | - | | Nutter Center · Dayton, OH |
| 26 | Sat Feb 5 | vs Oakland | W75-64 | 14-10 | .583 | - | | Nutter Center · Dayton, OH |
| 27 | Wed Feb 9 | atGreen Bay | W79-62 | 15-10 | .600 | - | | Resch Center · Ashwaubenon, WI |
| 28 | Fri Feb 11 | atMilwaukee | L57-60 | 15-11 | .577 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 29 | Sun Feb 13 | vsN Kentucky | L71-75 | 15-12 | .556 | - | | Nutter Center · Dayton, OH |
| 30 | Fri Feb 18 | atOakland | W78-74 | 16-12 | .571 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 31 | Sun Feb 20 | atDetroit Mercy | L75-80 | 16-13 | .552 | - | | Calihan Hall · Detroit, MI |
| 32 | Thu Feb 24 | vsYoungstown St | W84-71 | 17-13 | .567 | - | | Nutter Center · Dayton, OH |
| 33 | Sat Feb 26 | vsRobert Morris | W71-61 | 18-13 | .581 | - | | Nutter Center · Dayton, OH |
| 34 | Thu Mar 3 | vsOakland | W75-63 | 19-13 | .594 | - | | Nutter Center · Dayton, OH |
| 35 | Mon Mar 7 | atCleveland St | W82-67 | 20-13 | .606 | - | ESPNU | Wolstein Center · Cleveland, OH |
| 36 | Tue Mar 8 | atN Kentucky | W72-71 | 21-13 | .618 | - | ESPN | Truist Arena · Highland Heights, KY |
| 37 | Wed Mar 16 | vs #16Bryant | W93-82 | 22-13 | .629 | #16 | truTV | Nutter Center · Dayton, OH |
| 38 | Fri Mar 18 | at #1Arizona | L70-87 | 22-14 | .611 | #16 | truTV | McKale Center · Tucson, AZ |
