| 1 | Mon Nov 3 | vs TBD | W86-37 | 1-0 | 1.000 | - | ESPN+ | Nutter Center · Dayton, OH |
| 2 | Thu Nov 6 | atCalifornia | L67-77 | 1-1 | .500 | - | ACC Extra | Haas Pavilion · Berkeley, CA |
| 3 | Tue Nov 11 | vsToledo | L71-81 | 1-2 | .333 | - | ESPN+ | Nutter Center · Dayton, OH |
| 4 | Sat Nov 15 | atRadford | W92-59 | 2-2 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 5 | Sun Nov 16 | atKent State | L72-76 (OT) | 2-3 | .400 | - | | M.A.C. Center · Kent, OH |
| 6 | Thu Nov 20 | vsTBD | W100-47 | 3-3 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 7 | Tue Nov 25 | atStetson | W79-62 | 4-3 | .571 | - | ESPN+ | Edmunds Center · Deland, FL |
| 8 | Fri Nov 28 | atButler | L69-94 | 4-4 | .500 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Wed Dec 3 | atYoungstown St | L68-69 | 4-5 | .444 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 10 | Sun Dec 7 | vsGreen Bay | W86-58 | 5-5 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 11 | Sat Dec 13 | atMarshall | L74-76 | 5-6 | .455 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 12 | Tue Dec 16 | vsMiami OH | L76-83 | 5-7 | .417 | - | ESPN+ | Nutter Center · Dayton, OH |
| 13 | Mon Dec 22 | vsE Michigan | W70-64 | 6-7 | .462 | - | ESPN+ | Nutter Center · Dayton, OH |
| 14 | Mon Dec 29 | vsOakland | W88-73 | 7-7 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 15 | Thu Jan 1 | vsMilwaukee | W76-70 | 8-7 | .533 | - | ESPN+ | Nutter Center · Dayton, OH |
| 16 | Sun Jan 4 | atIU Indy | W81-77 | 9-7 | .563 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 17 | Fri Jan 9 | atDetroit Mercy | W84-82 | 10-7 | .588 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 18 | Sun Jan 11 | atOakland | W94-84 | 11-7 | .611 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 19 | Thu Jan 15 | vsYoungstown St | W93-83 | 12-7 | .632 | - | ESPN+ | Nutter Center · Dayton, OH |
| 20 | Wed Jan 21 | vsCleveland St | L79-85 | 12-8 | .600 | - | ESPN+ | Nutter Center · Dayton, OH |
| 21 | Sat Jan 24 | vsN Kentucky | W88-80 | 13-8 | .619 | - | ESPN+ | Nutter Center · Dayton, OH |
| 22 | Fri Jan 30 | atMilwaukee | W76-69 | 14-8 | .636 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 23 | Sun Feb 1 | atGreen Bay | W83-75 | 15-8 | .652 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 24 | Wed Feb 4 | atRobert Morris | L66-72 | 15-9 | .625 | - | ESPNU | UPMC Events Center · Moon Township, PA |
| 25 | Sat Feb 7 | vsPurdue FW | W73-68 | 16-9 | .640 | - | ESPN+ | Nutter Center · Dayton, OH |
| 26 | Thu Feb 12 | vsDetroit Mercy | L74-77 | 16-10 | .615 | - | ESPN+ | Nutter Center · Dayton, OH |
| 27 | Sun Feb 15 | atCleveland St | W102-90 | 17-10 | .630 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 28 | Thu Feb 19 | vsIU Indy | W85-73 | 18-10 | .643 | - | ESPN+ | Nutter Center · Dayton, OH |
| 29 | Sun Feb 22 | vsRobert Morris | L68-81 | 18-11 | .621 | - | ESPNU | Nutter Center · Dayton, OH |
| 30 | Wed Feb 25 | atPurdue FW | W74-70 | 19-11 | .633 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 31 | Sat Feb 28 | atN Kentucky | W92-91 | 20-11 | .645 | - | ESPN+ | Truist Arena · Highland Heights, KY |
