| 1 | Sun Sep 13 | vs Saints | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 2 | Thu Sep 17 | atBills | 8:15 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 3 | Sun Sep 27 | vsJets | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 4 | Sun Oct 4 | atPanthers | 8:20 PM | 0-0 | .000 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 11 | atCardinals | 4:25 PM | 0-0 | .000 | State Farm Stadium · Glendale, AZ |
| --bye week-- |
| 7 | Sun Oct 25 | vsPackers | 4:25 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 8 | Sun Nov 1 | vsVikings | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 9 | Sun Nov 8 | atDolphins | 1:00 PM | 0-0 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 10 | Sun Nov 15 | vsPatriots | 9:30 AM | 0-0 | .000 | Ford Field · Detroit, MI |
| 11 | Sun Nov 22 | vsBuccaneers | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 12 | Thu Nov 26 | vsBears | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 13 | Sun Dec 6 | atFalcons | 1:00 PM | 0-0 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| 14 | Sun Dec 13 | vsTitans | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 15 | Sun Dec 20 | atVikings | 8:20 PM | 0-0 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Mon Dec 28 | vsGiants | 8:15 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 17 | Sun Jan 3 | atBears | 4:25 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 18 | TBD | atPackers | TBD | 0-0 | .000 | Lambeau Field · Green Bay, WI |
