| 1 | Sun Sep 8 | at Buccaneers | L20-37 | 0-1 | .000 | Raymond James Stadium · Tampa, FL |
| 2 | Sun Sep 15 | vsGiants | W21-18 | 1-1 | .500 | FedEx Field · North Englewood, MD |
| 3 | Mon Sep 23 | atBengals | W38-33 | 2-1 | .667 | Paycor Stadium · Cincinnati, OH |
| 4 | Sun Sep 29 | atCardinals | W42-14 | 3-1 | .750 | State Farm Stadium · Glendale, AZ |
| 5 | Sun Oct 6 | vsBrowns | W34-13 | 4-1 | .800 | FedEx Field · North Englewood, MD |
| 6 | Sun Oct 13 | atRavens | L23-30 | 4-2 | .667 | M&T Bank Stadium · Baltimore, MD |
| 7 | Sun Oct 20 | vsPanthers | W40-7 | 5-2 | .714 | FedEx Field · North Englewood, MD |
| 8 | Sun Oct 27 | vsBears | W18-15 | 6-2 | .750 | FedEx Field · North Englewood, MD |
| 9 | Sun Nov 3 | atGiants | W27-22 | 7-2 | .778 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 10 | vsSteelers | L27-28 | 7-3 | .700 | FedEx Field · North Englewood, MD |
| 11 | Thu Nov 14 | atEagles | L18-26 | 7-4 | .636 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 24 | vsCowboys | L26-34 | 7-5 | .583 | FedEx Field · North Englewood, MD |
| 13 | Sun Dec 1 | vsTitans | W42-19 | 8-5 | .615 | FedEx Field · North Englewood, MD |
| --bye week-- |
| 15 | Sun Dec 15 | atSaints | W20-19 | 9-5 | .643 | Caesars Superdome · New Orleans, LA |
| 16 | Sun Dec 22 | vsEagles | W36-33 | 10-5 | .667 | FedEx Field · North Englewood, MD |
| 17 | Sun Dec 29 | vsFalcons | W30-24 (OT) | 11-5 | .688 | FedEx Field · North Englewood, MD |
| 18 | Sun Jan 5 | atCowboys | W23-19 | 12-5 | .706 | AT&T Stadium · Arlington, TX |
| WC | Sun Jan 12 | atBuccaneers | W23-20 | 12-5 | .706 | Raymond James Stadium · Tampa, FL |
| DIV | Sat Jan 18 | atLions | W45-31 | 12-5 | .706 | Ford Field · Detroit, MI |
| CONF | Sun Jan 26 | atEagles | L23-55 | 12-5 | .706 | Lincoln Financial Field · Philadelphia, PA |
