| 1 | Mon Nov 4 | at NJIT | W58-57 | 1-0 | 1.000 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
| 2 | Thu Nov 7 | vsMD-Eastern | W85-84 | 2-0 | 1.000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 3 | Tue Nov 12 | atLafayette | L63-65 | 2-1 | .667 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 4 | Fri Nov 15 | vsSaint Joseph's | L69-86 | 2-2 | .500 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 5 | Tue Nov 19 | atVillanova | L49-93 | 2-3 | .400 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 6 | Fri Nov 29 | vsNavy | L78-86 | 2-4 | .333 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 7 | Sat Nov 30 | vsMaine | W77-64 | 3-4 | .429 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 8 | Sun Dec 1 | vsElon | L53-68 | 3-5 | .375 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Sat Dec 7 | atDrexel | L47-60 | 3-6 | .333 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 10 | Mon Dec 9 | atVCU | L47-66 | 3-7 | .300 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 11 | Fri Dec 20 | vsRider | W79-66 | 4-7 | .364 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 12 | Sun Dec 22 | atGeorge Mason | L53-85 | 4-8 | .333 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 13 | Sun Dec 29 | atPenn State | L66-86 | 4-9 | .308 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 14 | Sat Jan 11 | atDartmouth | L70-73 | 4-10 | .286 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 15 | Sat Jan 18 | vsCornell | L76-86 | 4-11 | .267 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 16 | Mon Jan 20 | atHarvard | W82-67 | 5-11 | .313 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 17 | Sat Jan 25 | vsColumbia | W93-78 | 6-11 | .353 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 18 | Fri Jan 31 | vsBrown | L79-88 | 6-12 | .333 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 19 | Sat Feb 1 | vsYale | L61-90 | 6-13 | .316 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 20 | Fri Feb 7 | vsPrinceton | L59-61 | 6-14 | .300 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 21 | Fri Feb 14 | atYale | L71-72 | 6-15 | .286 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 15 | atBrown | L72-82 | 6-16 | .273 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 23 | Fri Feb 21 | vsDartmouth | W88-75 | 7-16 | .304 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 24 | Sat Feb 22 | vsHarvard | L78-79 (OT) | 7-17 | .292 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 25 | Fri Feb 28 | atCornell | L62-90 | 7-18 | .280 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 26 | Sat Mar 1 | atColumbia | W92-87 | 8-18 | .308 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 27 | Sat Mar 8 | atPrinceton | L71-95 | 8-19 | .296 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
